Clinical efficacy of Wumei Pills in the treatment of diarrhea and gastrointestinal dysfunction in sepsis patients

XU Guangxun; ZHANG Hongsheng; CAO Ying; QU Zhicheng; PEI Xiaolu

doi:10.16025/j.1674-1307.2025.01.011

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Clinical efficacy of Wumei Pills in the treatment of diarrhea and gastrointestinal dysfunction in sepsis patients

更新时间：2025-01-24

- Clinical efficacy of Wumei Pills in the treatment of diarrhea and gastrointestinal dysfunction in sepsis patients
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 1, Pages: 53-56(2025)
- 作者机构：
  
  首都医科大学附属北京中医医院急诊科，北京 100010
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.01.011
  CLC：
- Published：25 January 2025，
  
  Received：07 April 2024，
- 稿件说明：
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XU GUANGXUN, ZHANG HONGSHENG, CAO YING, et al. Clinical efficacy of Wumei Pills in the treatment of diarrhea and gastrointestinal dysfunction in sepsis patients. [J]. Beijing journal of traditional chinese medicine, 2025, 44(1): 53-56.
DOI：

XU GUANGXUN, ZHANG HONGSHENG, CAO YING, et al. Clinical efficacy of Wumei Pills in the treatment of diarrhea and gastrointestinal dysfunction in sepsis patients. [J]. Beijing journal of traditional chinese medicine, 2025, 44(1): 53-56. DOI： 10.16025/j.1674-1307.2025.01.011.

摘要

目的

观察乌梅丸汤剂治疗脓毒症合并腹泻及胃肠功能障碍的临床疗效。

方法

选取2016年4月—2022年3月就诊于首都医科大学附属北京中医医院急诊科的64例脓毒症合并腹泻及胃肠功能障碍患者为研究对象，通过随机数字表法将患者分为观察组和对照组，各32例。2组均给予常规治疗，观察组在常规治疗基础上加乌梅丸汤剂口服、鼻饲或直肠滴注。2组疗程均为7 d。观察2组病死率、腹泻疗效、安全性，及治疗前后胃肠功能障碍评分、序贯器官衰竭（SOFA）、急性生理与慢性健康评分系统Ⅱ（APACHE Ⅱ）评分。

结果

观察组死亡5例（16.13%），对照组死亡9例（29.03%），2组病死率差异无统计学意义（

0.05）。死亡

为0.85（95%

0.644～1.112）。观察组总有效率高于对照组（

0.05）。与治疗前比较，2组治疗后胃肠功能障碍评分、SOFA评分、APACHE Ⅱ评分均降低（

0.05），且观察组治疗后胃肠功能障碍评分、SOFA评分、APACHE Ⅱ评分均低于对照组（

0.05）。2组患者均未出现药物相关的不良反应，2组血常规及肝、肾功能均无异常改变。

结论

乌梅丸汤剂对脓毒症合并腹泻及胃肠功能障碍，有明显的胃肠保护作用，同时也能减轻患者整体病情严重程度。

Abstract

Objective

To observe the clinical efficacy of Wumei Pills decoction in the treatment of sepsis complicated with diarrhea and gastrointestinal dysfunction.

Method

Patients with sepsis complicated by diarrhea and gastrointestinal dysfunction who visited the Emergency Department of Beijing Hospital of Traditional Chinese Medicine， Capital Medical University from April 2016 to March 2022 were enrolled and randomly divided into an observation group and a control group using a random number table. Both groups received conventional treatment， with the observation group additionally receiving Wumei Pills decoction orally， via nasogastric tube， or rectal drip. The treatment duration was 7 days for both groups. The mortality rate， diarrhea efficacy， safety， and changes in gastrointestinal dysfunction scores， sequential organ failure assessment （SOFA） scores， and acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ） scores were observed before and after treatment.

Result

In the observation group， 5 deaths （16.13%） occurred， while in the control group， 9 deaths （29.03%） occurred. There was no statistically significant difference in mortality between the two groups （

0.05）， and the relative risk of death was 0.85 （95% CI： 0.644–1.112）. The overall effective rate in the observation group was higher than that in the control group （

0.05）. Compared with the results before treatment， both groups showed a decrease in gastrointestinal dysfunction scores， SOFA scores， and APACHE Ⅱ scores after treatment （

0.05）. Additionally， the observation group had significantly lower gastrointestinal dysfunction scores， SOFA scores， and APACHE Ⅱ scores than the control group after treatment （

0.05）. No drug-related adverse reactions occurred in either group， and there were no significant changes in blood routine or liver and kidney function in either group.

Conclusion

Wumei Pills decoction has a significant gastrointestinal protective effect on patients with sepsis complicated by diarrhea and gastrointestinal dysfunction， and it also alleviates the overall severity of the patient's condition.

关键词

乌梅丸脓毒症腹泻胃肠功能障碍

Keywords

Wumei Pillssepsisdiarrheagastrointestinal dysfunction

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