Role of activating blood and removing stasis in improving the lung cancer metastasis microenvironment based on the "state-target syndrome identification" theory

YUAN Mengqi; ZHENG Yingying; LIU Zishen; ZHANG Ganlin; YANG Guowang

doi:10.16025/j.1674-1307.2025.02.016

您当前的位置：

首页 >

文章列表页 >

Role of activating blood and removing stasis in improving the lung cancer metastasis microenvironment based on the "state-target syndrome identification" theory

更新时间：2025-03-19

- Role of activating blood and removing stasis in improving the lung cancer metastasis microenvironment based on the "state-target syndrome identification" theory
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 2, Pages: 191-195(2025)
- 作者机构：
  
  首都医科大学附属北京中医医院肿瘤科，北京 100010
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.02.016
  CLC：
- Received：30 June 2024，
  
  Published：25 February 2025
- 稿件说明：
移动端阅览
袁梦琪，郑瑛瑛，刘梓燊，等.基于“态靶辨治”探析活血化瘀法在改善肺癌转移微环境中的作用［J］.北京中医药，2025，44（2）：191-195.

YUAN Mengqi,ZHENG Yingying,LIU Zishen,et al.Role of activating blood and removing stasis in improving the lung cancer metastasis microenvironment based on the "state-target syndrome identification" theory[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(02):191-195.
袁梦琪，郑瑛瑛，刘梓燊，等.基于“态靶辨治”探析活血化瘀法在改善肺癌转移微环境中的作用［J］.北京中医药，2025，44（2）：191-195. DOI： 10.16025/j.1674-1307.2025.02.016.

YUAN Mengqi,ZHENG Yingying,LIU Zishen,et al.Role of activating blood and removing stasis in improving the lung cancer metastasis microenvironment based on the "state-target syndrome identification" theory[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(02):191-195. DOI： 10.16025/j.1674-1307.2025.02.016.

摘要

肺癌是全球发病率和死亡率最高的癌症，由于其发病隐匿，多数患者一经发现就处于晚期，因此积极防治肺癌的复发转移具有重要意义。中医学认为瘀毒内停是晚期肺癌的主要病理特征。“态靶辨治”理论是仝小林院士基于现代医学背景下提出的中医诊疗新模式，基于此理论体系从晚期肺癌的“瘀态”病靶”“症靶”和“标靶”四个方面对晚期肺癌肿瘤微环境进行阐释，临床可运用活血化瘀法调晚期肺癌之“瘀态”，温阳化瘀打晚期肺癌之“靶标”。

Abstract

关键词

Keywords

references

BRAY F , LAVERSANNE M , SUNG H , et al . Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J ] . CA Cancer J Clin , 2024 , 74 ( 3 ): 229 - 263 .

ALLEMANI C , MATSUDA T , DI CARLO V , et al . Global surveillance of trends in cancer survival 2000-14 (CONCORD-3):analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries [J ] . Lancet , 2018 , 391 ( 10125 ): 1023 - 1075 .

CASAL-MOURINO A , RUANO-RAVINA A , LORENZO-GONZALEZ M , et al . Epidemiology of stage III lung cancer:frequency, diagnostic characteristics,and survival [J ] . Transl Lung Cancer Res , 2021 , 10 ( 1 ): 506 - 518 .

蒋立峰 , 桑锋 , 刘怀民 , 等 . 清肺化瘀解毒方治疗非小细胞肺癌吉非替尼获得性耐药临床疗效观察 [J ] . 中华中医药杂志 , 2023 , 38 ( 11 ): 5575 - 5578 .

陈菲菲 , 李畅 , 罗毅 , 等 . 微粒型灵芝孢子β-葡聚糖重塑免疫抑制微环境增强吉西他滨抗肺癌作用 [J ] . 药学学报 , 2021 , 56 ( 7 ): 1988 - 1998 .

WANG L , WU W , ZHU X , et al . The ancient Chinese Decoction Yu-Ping-Feng suppresses orthotopic lewis lung cancer tumor growth through increasing M1 macrophage polarization and CD4 + T Cell cytotoxicity [J ] . Front Pharmacol , 2019 , 10 : 1333 .

仝小林 , 何莉莎 , 赵林华 . 论“态靶因果”中医临床辨治方略 [J ] . 中医杂志 , 2015 , 56 ( 17 ): 1441 - 1444 .

HESSEY S , FESSAS P , ZACCARIA S , et al . Insights into the metastatic cascade through research autopsies [J ] . Trends Cancer , 2023 , 9 ( 6 ): 490 - 502 .

MATTIUZZI C , LIPPI G . Current Cancer Epidemiology [J ] . J Epidemiol Glob Health , 2019 , 9 ( 4 ): 217 - 222 .

陈小春 , 李志明 , 江威 . 活血化瘀法治疗肺恶性肿瘤血瘀状态的研究进展 [J ] . 江西中医药 , 2023 , 54 ( 11 ): 76 - 79 .

韩啸东 , 张侠 , 刘畅 , 等 . 非小细胞肺癌患者血液高凝状态的临床调查 [J ] . 现代生物医学进展 , 2015 , 15 ( 5 ): 882 - 886,877 .

李丛煌 , 花宝金 . 283例中晚期非小细胞肺癌患者证候分布及证候要素组合特点分析 [J ] . 北京中医药大学学报 , 2009 , 32 ( 10 ): 712 - 5 .

孙颖 . 晚期非小细胞肺癌证型特点及血瘀证相关因素研究 [D ] . 天津 : 天津中医药大学 , 2020 .

王笑民，郁仁存，王禹堂，等 . 晚期非小细胞肺癌患者气虚血瘀证的研究 [J ] . 中国中西医结合杂志 , 1994 , 14 ( 12 ): 724 - 726 .

左明焕 , 王芬 , 孙韬 . 晚期肺癌的中医证候研究 [J ] . 北京中医药大学学报（中医临床版） , 2003 , 10 ( 4 ): 7 - 9 .

杨丹 , 田国庆 , 王景 , 等 . 原发性支气管肺癌中医证型分布特点的研究 [J ] . 中国全科医学 , 2010 , 13 ( 32 ): 3607 - 3611 .

骆亚莉 , 周啸天 , 魏本君 , 等 . 中医学对炎性微环境与炎症恶性转化的认识 [J ] . 时珍国医国药 , 2022 , 33 ( 8 ): 1966 - 1968 .

陈雪 , 何善泉 , 徐心瑶 , 等 . 肺瘤平膏调控肿瘤炎性微环境NF-κB信号通路抑制Lewis肺癌的效应机制 [J ] . 北京中医药 , 2022 , 41 ( 5 ): 484 - 489 .

张葛 , 花宝金 . 从炎性微环境探究中医肿瘤病机与治则治法 [J ] . 中医杂志 , 2012 , 53 ( 13 ): 1101 - 1104 .

蔡云 , 陈远彬 , 叶放 , 等 . 国医大师周仲瑛从癌毒理论辨治肺癌经验述要 [J ] . 中华中医药杂志 , 2020 , 35 ( 6 ): 2879 - 2882 .

郭力恒 , 张敏州 , 陈伯钧 . 邓铁涛教授调脾护心法治疗冠心病介入术医案4则 [J ] . 新中医 , 2002 , 34 ( 7 ): 14 - 15 .

MASUDA E , SISTA AK , PUA BB , et al . Palliative procedures in lung cancer [J ] . Semin Intervent Radiol , 2013 , 30 ( 2 ): 199 - 205 .

陈政伟 , 尹怡 , 王祥麒 . 王祥麒教授从“阳虚失血”论治肺癌咯血经验 [J ] . 中医临床研究 , 2024 , 16 ( 6 ): 77 - 80 .

PSALLIDAS I , KALOMENIDIS I , PORCEL JM , et al . Malignant pleural effusion: from bench to bedside [J ] . Eur Respir Rev , 2016 , 25 ( 140 ): 189 - 198 .

KOEGELENBERG C , SHAW J A , IRUSEN E M , et al . Contemporary best practice in the management of malignant pleural effusion [J ] . Ther Adv Respir Dis , 2018 , 12 : 1753466618785098 .

WU DW , CHANG WA , LIU KT , et al . Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion [J ] . Oncol Lett , 2017 , 14 ( 3 ): 3657 - 3662 .

马睿 , 刘飞艳 , 苏峰 , 等 . VEGF在恶性胸腔积液中的作用 [J ] . 中国辐射卫生 , 2017 , 26 ( 4 ): 507 - 510 .

JOHN A , GORZELANNY C , BAUER AT , et al . Role of the Coagulation System in Genitourinary Cancers: Review [J ] . Clin Genitourin Cancer , 2017 , 26 : S1558-7673(17)30210 - 0 .

GASIC GJ , GASIC TB , STEWART CC . Antimetastatic effects associated with platelet reduction [J ] . Proc Natl Acad Sci USA , 1968 , 61 ( 1 ): 46 - 52 .

MA Y , LI G , YU M , et al . Prognostic significance of thrombocytosis in lung cancer:a systematic review and meta-analysis [J ] . Platelets , 2021 , 32 ( 7 ): 919 - 927 .

JOYCE JA , POLLARD JW . Microenvironmental regulation of metastasis [J ] . Nat Rev Cancer , 2009 , 9 ( 4 ): 239 - 252 .

JIANG L , LUAN Y , MIAO X , et al . Platelet releasate promotes breast cancer growth and angiogenesis via VEGF-integrin cooperative signalling [J ] . Br J Cancer , 2017 , 117 ( 5 ): 695 - 703 .

MORRIS K , SCHNOOR B , PAPA AL . Platelet cancer cell interplay as a new therapeutic target [J ] . Biochim Biophys Acta Rev Cancer , 2022 , 1877 ( 5 ): 188770 .

HAEMMERLE M , STONE RL , MENTER DG , et al . The platelet lifeline to cancer: challenges and opportunities [J ] . Cancer Cell , 2018 , 33 ( 6 ): 965 - 983 .

LIVERANI E , KILPATRICK LE , TSYGANKOV AY , et al . The role of P2Y12 receptor and activated platelets during inflammation [J ] . Curr Drug Targets , 2014 , 15 ( 7 ): 720 - 728 .

徐咏梅 , 郁仁存 . 益气活血法治疗肿瘤经验 [J ] . 中医杂志 , 2010 , 51 ( S1 ): 110 - 111 .

郑青秀 , 徐小小 , 刘刚 , 等 . 补阳还五汤对气虚血瘀型肺癌患者血液高凝状态的影响 [J ] . 中国临床药理学与治疗学 , 2018 , 23 ( 6 ): 694 - 699 .

逄艳 , 张芳 . 补阳还五汤改善晚期肺癌高凝状态的临床研究 [J ] . 云南中医中药杂志 , 2017 , 38 ( 7 ): 33 - 34 .

杨珊 , 黄立中 , 肖玉洁 , 等 . 黄立中治疗肺癌咯血经验 [J ] . 湖南中医杂志 , 2019 , 35 ( 5 ): 22 - 24 .

闫子民 , 齐文升 . 峻下逐水法治疗恶性胸腔积液1则 [J ] . 北京中医药 , 2023 , 42 ( 1 ): 122 - 124 .

李学臣 , 张涛 , 魏晓东 . 三棱提取物对H22荷瘤小鼠的抑瘤作用 [J ] . 黑龙江医药科学 , 2010 , 33 ( 5 ): 78 .

安庆文 . 基于活血化瘀法探讨丹参二萜醌通过JAK1/STAT3通路治疗血瘀证肺癌 [D ] . 杭州 : 浙江中医药大学 , 2024 .

DAI B , QI J , LIU R , et al . Eupolyphaga sinensis Walker demonstrates angiogenic activity and inhibits A549 cell growth by targeting the KDR signaling pathway [J ] . Mol Med Rep , 2014 , 10 ( 3 ): 1590 - 1596 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

LI Yueqing's experience in treating refractory erectile dysfunction from the perspective of "stasis"

QI Bao-yu's clinical experience in using the method for promoting blood circulation and removing blood stasis to treat diseases related to retinal blood syndrome

Discussion of GUO Shi-kui's thoughts on treatment of angina pectoris

Clinical experience of treating kidney diseases with method for promoting blood circulation and removing blood stasis

Related Author

SUN Song

LI Yueqing

FENG Junlong

MA Jianxion

WANG Jisheng

WANG Bin

LI Haisong

HUANG Nianwen

Related Institution

北京中医药大学东直门医院男科

浙江中医药大学第一附属医院肾病科

北京市昌平区中医医院男科

中国中医科学院眼科医院眼功能检查科

北京中医药大学东方医院眼科

⁰