Traditional Chinese medicine treatment of idiopathic pulmonary fibrosis based on NLRP3 inflammasome: a review

LYU Anqi; JIANG Cheng; ZUO Wanzhao; YANG Zhenyu; HE Cong; YANG Yi; KE Jia

doi:10.16025/j.1674-1307.2025.02.029

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Traditional Chinese medicine treatment of idiopathic pulmonary fibrosis based on NLRP3 inflammasome: a review

更新时间：2025-03-19

- Traditional Chinese medicine treatment of idiopathic pulmonary fibrosis based on NLRP3 inflammasome: a review
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 2, Pages: 253-260(2025)
- 作者机构：
  
  1.湖北中医药大学中医学院，武汉 430060
  2.湖北省中医院湖北时珍实验室湖北中医药大学附属医院，武汉 430074
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.02.029
  CLC：
- Received：14 January 2024，
  
  Published：25 February 2025
- 稿件说明：
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吕安淇，姜成，左婉曌，等.基于NLRP3炎症小体的中医药干预特发性肺纤维化研究进展［J］.北京中医药，2025，44（2）：253-260.

LYU Anqi,JIANG Cheng,ZUO Wanzhao,et al.Traditional Chinese medicine treatment of idiopathic pulmonary fibrosis based on NLRP3 inflammasome: a review[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(02):253-260.
吕安淇，姜成，左婉曌，等.基于NLRP3炎症小体的中医药干预特发性肺纤维化研究进展［J］.北京中医药，2025，44（2）：253-260. DOI： 10.16025/j.1674-1307.2025.02.029.

LYU Anqi,JIANG Cheng,ZUO Wanzhao,et al.Traditional Chinese medicine treatment of idiopathic pulmonary fibrosis based on NLRP3 inflammasome: a review[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(02):253-260. DOI： 10.16025/j.1674-1307.2025.02.029.

摘要

特发性肺纤维化（IPF）是一种原因不明、进行性致纤维化的间质性肺炎，起病隐匿，多发于老年人群，死亡率高，且严重影响患者的生存质量。目前研究发现，NOD样受体热蛋白结构域相关蛋白3（NLRP3）炎症小体的异常激活参与IPF的病理进程，影响了一系列转录因子并促进肌成纤维细胞的激活，从而促进IPF的发生和发展。因此，阻断NLRP3的异常激活有助于延缓IPF的进程。而中医药具有多通路、多靶点的特点，具有一定的抗纤维化作用，中药单体或复方可通过抑制NLRP3炎症小体激活并延缓IPF的发生发展。

Abstract

Idiopathic pulmonary fibrosis （IPF） is a progressive interstitial pneumonia characterized by unexplained fibrosis and an insidious onset. It predominantly affects the elderly population， is associated with a high mortality rate， and significantly diminishes patients' quality of life. Recent findings indicate that the abnormal activation of NOD-like receptor thermoprotein structural domain-related protein 3 （NLRP3） inflammatory vesicles plays a crucial role in the pathological process of IPF. This activation influences a series of transcription factors and promotes the activation of myofibroblasts， thereby facilitating the onset and progression of IPF. Consequently， inhibiting the abnormal activation of NLRP3 may help slow the progression of the disease. Traditional Chinese medicine （TCM）， known for its multi-pathway and multi-targeting properties， exhibits certain anti-fibrotic effects. TCM monomers or combinations have been shown to inhibit the activation of NLRP3 inflammatory vesicles， potentially slowing the development of IPF.

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references

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