Biological connotation of the pathogenesis of type 2 diabetes characterized by "spleen deficiency and liver depression" based on the interaction between intestinal flora and bile acids

ZHANG Jianwen; GAO Huijuan; XIE Cong; QI Cong; MENG Xing; FU Hongyuan; LING Guoxing; LIN Yunhan; AIFEILA Aikepaer; WANG Chunchan; CHEN Yuanhao; FENG Xingzhong

doi:10.16025/j.1674-1307.2025.03.021

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Biological connotation of the pathogenesis of type 2 diabetes characterized by "spleen deficiency and liver depression" based on the interaction between intestinal flora and bile acids

更新时间：2025-04-29

- Biological connotation of the pathogenesis of type 2 diabetes characterized by "spleen deficiency and liver depression" based on the interaction between intestinal flora and bile acids
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 3, Pages: 365-370(2025)
- 作者机构：
  
  1.清华大学玉泉医院清华大学中西医结合医院内分泌科，北京 100040
  2.清华大学，北京 100084
  3.天津中医药大学，天津301617
  4.北京中医药大学，北京 100105
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.03.021
  CLC：
- Received：09 May 2024，
  
  Published：25 March 2025
- 稿件说明：
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张建文，高慧娟，谢聪，等.基于“肠道菌群-胆汁酸”互作论2型糖尿病“土虚木郁”的病机［J］.北京中医药，2025，44（3）：365-370.

ZHANG Jianwen,GAO Huijuan,XIE Cong,et al.Biological connotation of the pathogenesis of type 2 diabetes characterized by "spleen deficiency and liver depression" based on the interaction between intestinal flora and bile acids[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(03):365-370.
张建文，高慧娟，谢聪，等.基于“肠道菌群-胆汁酸”互作论2型糖尿病“土虚木郁”的病机［J］.北京中医药，2025，44（3）：365-370. DOI： 10.16025/j.1674-1307.2025.03.021.

ZHANG Jianwen,GAO Huijuan,XIE Cong,et al.Biological connotation of the pathogenesis of type 2 diabetes characterized by "spleen deficiency and liver depression" based on the interaction between intestinal flora and bile acids[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(03):365-370. DOI： 10.16025/j.1674-1307.2025.03.021.

摘要

肠道菌群与胆汁酸代谢的互作失衡与2型糖尿病（type 2 diabetes mellitus，T2DM）的发生密切相关。基于中医理论及多项西医学研究发现，肠道菌群失调与中医“土虚”密切相关，胆汁酸代谢异常为“木郁”的微观体现。“土虚”是T2DM的病理基础，“木郁”是其发病的始动因素，“土虚木郁”与肠道菌群-胆汁酸互作关系失衡高度契合，且是T2DM的关键病机。从“肠道菌群-胆汁酸互作”角度探讨T2DM“土虚木郁”的生物学内涵，对于指导中医药防治T2DM有重要意义。

Abstract

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references

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