Clinical observation of <italic style="font-style: italic">Yiwei Jiedu Formula</italic> combined with <italic style="font-style: italic">Fuweisan Capsules</italic> in the treatment of Helicobacter pylori-positive gastric precancerous lesions with spleen and stomach deficiency syndrome

WANG Liye; ZHANG Yanbin; ZHU Yanan; WANG Chong; LI Jing; LIU Kangkang; XU Xiaowei; ZHU Yuguang

doi:10.16025/j.1674-1307.2025.05.006

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Clinical observation of Yiwei Jiedu Formula combined with Fuweisan Capsules in the treatment of Helicobacter pylori-positive gastric precancerous lesions with spleen and stomach deficiency syndrome

更新时间：2025-07-07

- Clinical observation of Yiwei Jiedu Formula combined with Fuweisan Capsules in the treatment of Helicobacter pylori-positive gastric precancerous lesions with spleen and stomach deficiency syndrome
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 5, Pages: 566-570(2025)
- 作者机构：
  
  1.石家庄市中医院郭光业传承工作室，石家庄 050051
  2.石家庄市中医院检验科，石家庄 050051
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.05.006
  CLC：
- Received：12 December 2023，
  
  Published：25 May 2025
- 稿件说明：
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王立业，张艳彬，朱亚楠，等.益胃解毒方联合复胃散胶囊治疗脾胃虚弱型幽门螺杆菌阳性胃癌前病变临床观察［J］.北京中医药，2025，44（5）：566-570.

WANG Liye,ZHANG Yanbin,ZHU Yanan,et al.Clinical observation of Yiwei Jiedu Formula combined with Fuweisan Capsules in the treatment of Helicobacter pylori-positive gastric precancerous lesions with spleen and stomach deficiency syndrome[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(05):566-570.
王立业，张艳彬，朱亚楠，等.益胃解毒方联合复胃散胶囊治疗脾胃虚弱型幽门螺杆菌阳性胃癌前病变临床观察［J］.北京中医药，2025，44（5）：566-570. DOI： 10.16025/j.1674-1307.2025.05.006.

WANG Liye,ZHANG Yanbin,ZHU Yanan,et al.Clinical observation of Yiwei Jiedu Formula combined with Fuweisan Capsules in the treatment of Helicobacter pylori-positive gastric precancerous lesions with spleen and stomach deficiency syndrome[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(05):566-570. DOI： 10.16025/j.1674-1307.2025.05.006.

摘要

目的

观察益胃解毒方联合复胃散胶囊治疗脾胃虚弱型幽门螺杆菌（Hp）阳性胃癌前病变的临床疗效。

方法

选取2019年6月—2022年6月石家庄市中医院收治的150例脾胃虚弱型Hp阳性胃癌前病变患者，采用随机数字表法分为3组，各50例。对照A组以益胃解毒方治疗，对照B组以复胃散胶囊治疗，观察组以益胃解毒方联合复胃散胶囊治疗，3组均以4周为1个疗程，连续治疗3个疗程。观察3组治疗前后胃黏膜病理状态（胃黏膜萎缩、上皮化生、异型增生、炎症活动度情况）评分、胃功能指标［胃蛋白酶原I（PG Ⅰ）、PG Ⅱ、胃泌素-17（G-17）］、可易位基因C（C-myc）、原癌基因（c-erbB-2）、炎症因子［热休克蛋白70（HSP70）、白细胞介素10（IL-10）、血清淀粉样蛋白A（SAA）］，并比较临床疗效。

结果

观察组总有效率高于对照A组、对照B组（

0.05）。治疗后，观察组胃黏膜病理状态评分均低于对照A组、对照B组（

0.05），胃功能指标（PG Ⅰ、PG Ⅱ、G-17）、C-myc、c-erbB-2及炎症因子（HSP70、IL-10、SAA）水平均低于对照A组、对照B组（

0.05）。治疗期间观察组、对照A组、对照B组不良反应发生率比较，差异无统计学意义（

0.05）。

结论

益胃解毒方联合复胃散胶囊治疗Hp阳性胃癌前病变可有效改善胃黏膜病理变化及胃功能，抑制C-myc、c-erbB-2及炎症因子表达，临床有效且安全性良好。

Abstract

Objective

To observe the clinical efficacy of

Yiwei Jiedu Formula

combined with

Fuweisan Capsules

in treating Helicobacter pylori （Hp）-positive gastric precancerous lesions with spleen and stomach deficiency syndrome.

Methods

A total of 150 patients with Hp-positive gastric precancerous lesions admitted to Shijiazhuang Hospital of Traditional Chinese Medicine from June 2019 to June 2022 were enrolled and randomly divided into three groups using a random number table method， with 50 cases in each group. Control group A was treated with

Yiwei Jiedu Formula

， control group B was treated with

Fuweisan Capsules

， and the observation group received

Yiwei Jiedu Formula

combined with

Fuweisan Capsules

. Each group was treated continuously for three courses， with each course lasting four weeks. Gastroscopic pathological scores （including gastric mucosal atrophy， intestinal metaplasia， dysplasia， and inflammatory activity）， gastric function indicators ［pepsinog

en I （PG I）， pepsinogen II （PG II）， gastrin-17 （G-17）］， expression levels of translocation gene C （C-myc）， proto-oncogene （c-erbB-2）， and inflammatory factors ［heat shock protein 70 （HSP70）， interleukin-10 （IL-10）， serum amyloid A （SAA）］ were observed before and after treatment， along with clinical efficacy comparison.

Results

The total effective rate in the observation group was higher than that in control group A and control group B （

0.05）. After treatment， gastroscopic pathological scores in the observation group were lower than those in the two control groups （

0.05）. Gastric function indicators （PG I， PG II， G-17）， C-myc， c-erbB-2， and inflammatory factors （HSP70， IL-10， SAA） were also significantly lower in the observation group compared with the control groups （

0.05）. There was no significant difference in the incidence of adverse reactions among the observation group， control group A， and control group B during treatment （

0.05）.

Conclusion

Yiwei Jiedu Formula

combined with

Fuweisan Capsules

effectively improves gastric mucosal pathological changes and gastric function， inhibits the expression of C-myc， c-erbB-2， and inflammatory factors， and is clinically effective with good safety in the treatment of Hp-positive gastric precancerous lesions.

关键词

Keywords

references

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Clinical observation of Yiwei Jiedu Formula combined with Fuweisan Capsules in the treatment of Helicobacter pylori-positive gastric precancerous lesions with spleen and stomach deficiency syndrome

DOI：10.16025/j.1674-1307.2025.05.006

摘要

Abstract

关键词

Keywords

references