Effect of aging on neurodegenerative diseases from the theory of "deficiency" and "loss"

ZHANG Han; LI Nannan; KANG Shenghua; WANG Liye; CHEN Zhigang

doi:10.16025/j.1674-1307.2025.06.021

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Effect of aging on neurodegenerative diseases from the theory of "deficiency" and "loss"

更新时间：2025-08-04

- Effect of aging on neurodegenerative diseases from the theory of "deficiency" and "loss"
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 6, Pages: 767-772(2025)
- 作者机构：
  
  1.北京中医药大学，北京 100029
  2.北京中医药大学东方医院脑病一科，北京 100078
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.06.021
  CLC：
- Received：15 May 2024，
  
  Published：25 June 2025
- 稿件说明：
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张含，李楠楠，康盛华，等.从虚损理论探讨衰老对神经退行性疾病的影响［J］.北京中医药，2025，44（6）：767-772.

ZHANG Han,LI Nannan,KANG Shenghua,et al.Effect of aging on neurodegenerative diseases from the theory of "deficiency" and "loss"[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(06):767-772.
张含，李楠楠，康盛华，等.从虚损理论探讨衰老对神经退行性疾病的影响［J］.北京中医药，2025，44（6）：767-772. DOI： 10.16025/j.1674-1307.2025.06.021.

ZHANG Han,LI Nannan,KANG Shenghua,et al.Effect of aging on neurodegenerative diseases from the theory of "deficiency" and "loss"[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(06):767-772. DOI： 10.16025/j.1674-1307.2025.06.021.

摘要

衰老是神经退行性疾病发生的危险因素，线粒体功能障碍、氧化应激、慢性炎症及血管老化等参与了神经系统衰老的过程，最终诱发神经退行性疾病。中医学认为脑衰老的过程始终伴随“虚”和“损”的病理状态，“虚”即脏腑功能的减退，气血、阴精、阳气不足所致大脑功能低下状态；“损”则是在虚的基础上，产生的有形病理产物对大脑的功能及结构造成进一步的消耗与损伤。虚为损之因，损为虚之渐，由此形成恶性循环，加速衰老进程。

Abstract

Aging is a risk factor for neurodegenerative diseases. Mitochondrial dysfunction， oxidative stress， chronic inflammation， and vascular aging contribute to the aging process of the nervous system， ultimately inducing neurodegenerative diseases. Traditional Chinese medicine （TCM） holds that brain aging is always accompanied by pathological processes of "deficiency" and "loss". "Deficiency" refers to the decline of visceral functions with aging， resulting in decreased brain function due to insufficiency of

， blood，

yin

essence， and

yang qi

. "Loss" refers to the further consumption and damage to

brain function and structure caused by the production of tangible pathological products based on deficiency. Deficiency is the cause of loss， and loss is the gradual progression of deficiency. This vicious cycle accelerates the aging process and leads to various diseases.

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Keywords

references

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