Differentiation and treatment of late-onset hypogonadism based on the theory of "decline of <italic style="font-style: italic">Yangming</italic> meridian-kidney <italic style="font-style: italic">qi</italic> deficiency"

CHENG Haoyang; ZHANG Xiaoyan; CAO Dezhong; LUO Chenglong; ZHANG Qi; ZHANG Sizheng; JIAO Yongzheng

doi:10.16025/j.1674-1307.2025.06.022

您当前的位置：

首页 >

文章列表页 >

Differentiation and treatment of late-onset hypogonadism based on the theory of "decline of Yangming meridian-kidney qi deficiency"

更新时间：2025-08-04

- Differentiation and treatment of late-onset hypogonadism based on the theory of "decline of Yangming meridian-kidney qi deficiency"
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 6, Pages: 773-777(2025)
- 作者机构：
  
  1.中国中医科学院广安门医院男科，北京 100053
  2.西安市中医医院皮肤科，西安 710001
  3.北京市东城区;第一人民医院中医科，北京 100077
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.06.022
  CLC：
- Received：07 June 2024，
  
  Published：25 June 2025
- 稿件说明：
移动端阅览
程皓洋，张小燕，曹得中，等.基于“阳明脉衰-肾气衰”辨治迟发性性腺功能减退症［J］.北京中医药，2025，44（6）：773-777.

CHENG Haoyang,ZHANG Xiaoyan,CAO Dezhong,et al.Differentiation and treatment of late-onset hypogonadism based on the theory of "decline of Yangming meridian-kidney qi deficiency"[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(06):773-777.
程皓洋，张小燕，曹得中，等.基于“阳明脉衰-肾气衰”辨治迟发性性腺功能减退症［J］.北京中医药，2025，44（6）：773-777. DOI： 10.16025/j.1674-1307.2025.06.022.

CHENG Haoyang,ZHANG Xiaoyan,CAO Dezhong,et al.Differentiation and treatment of late-onset hypogonadism based on the theory of "decline of Yangming meridian-kidney qi deficiency"[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(06):773-777. DOI： 10.16025/j.1674-1307.2025.06.022.

摘要

迟发性性腺功能减退症（late-onset hypogonadism，LOH）是发生于中老年男性的常见病。中医药治疗可有效改善LOH症状，中医认为在LOH发病过程中，“阳明脉衰”驱动“肾气衰”；脂肪组织（adipose tissue， AT）功能障碍可能是阳明脉衰、脾失健运的重要表现。治疗LOH应当兼顾脾肾，养后天以滋先天，可采用健脾益气、滋阴补肾，温肾暖脾、益气助阳，健脾补肾、利湿化浊之法，调理阳明、培补肾气。

Abstract

Late-onset hypogonadism （LOH） is a common condition in middle-aged and elderly men that severely affects their quality of life. Traditional Chinese medicine （TCM）can effectively improve LOH symptoms. TCM theory holds that in the pathogenesis of LOH， "decline of the

Yangming

meridian" drives "kidney

deficiency". Dysfunction of adipose tissue （AT） may be an important manifestation of

Yangming

meridian decline and spleen dysfunction. Treatment of LOH should address both the spleen and kidney， nourishing the acquired constitution to support the innate constitution. Methods such as invigorating the spleen and benefiting

， nourishing

yin

and tonifying the kidney， warming the kidney and spleen， benefiting

to assist

yang

， strengthening the spleen and kidney， and promoting diuresis to remove turbidity can be used to regulate the

Yangming

meridian and reinforce kidney

关键词

Keywords

references

SALONIA A , CAPOGROSSO P , BOERI L , et al . European Association of Urology guidelines on male sexual and reproductive health: 2025 update on male hypogonadism, erectile dysfunction, premature ejaculation, and peyronie's disease [J ] . Eur Urol , 2025 , 88 ( 1 ): 76 - 102 .

CORONA G , GOULIS DG , HUHTANIEMI I , et al . European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology [J ] . Andrology , 2020 , 8 ( 5 ): 970 - 987 .

邓春华，商学军 . 男科疾病诊断治疗指南2022版 [M ] . 北京 : 中华医学电子音像出版社 , 2022 : 311 - 361 .

高士宗 , 于天星 . 黄帝素问直解 [M ] . 北京 : 科学技术文献出版社 , 1982 : 4 .

杜怀棠，周丽珍 . 近10年中医衰老学说研究述评 [J ] . 北京中医药大学学报 , 1995 ( 2 ): 2 - 7,72 .

纪云西 , 黄贵华 , 蒋历 , 等 . 脾之“运与化”浅析 [J ] . 时珍国医国药 , 2013 , 24 ( 2 ): 454 - 455 .

COHEN P , KAJIMURA S . The cellular and functional complexity of thermogenic fat [J ] . Nat Rev Mol Cell Biol , 2021 , 22 ( 6 ): 393 - 409 .

CINTI S . Obesity, type 2 diabetes and the adipose organ: a pictorial atlas from research to clinical applications [M ] . Switzerland : Springer , 2018 .

OU MY , ZHANG H , TAN PC , et al . Adipose tissue aging: mechanisms and therapeutic implications [J ] . Cell Death Dis , 2022 , 13 ( 4 ): 300 .

PéREZ LM , PAREJA-GALEANO H , SANCHIS-GOMAR F , et al . " Adipaging": ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue [J ] . J Physiol , 2016 , 594 ( 12 ): 3187 - 3207 .

宁港 , 吴悔 , 周兴 . 浅析天癸与睾酮的相关性 [J ] . 湖南中医药大学学报 , 2022 , 42 ( 1 ): 73 - 77 .

FELDMAN HA , LONGCOPE C , DERBY CA , et al . Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study [J ] . J Clin Endocrinol Metab , 2002 , 87 ( 2 ): 589 - 598 .

HARMAN SM , METTER EJ , TOBIN JD , et al . Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging [J ] . J Clin Endocrinol Metab , 2001 , 86 ( 2 ): 724 - 731 .

KAUFMAN JM , VERMEULEN A . Declining gonadal function in elderly men [J ] . Baillieres Clin Endocrinol Metab , 1997 , 11 ( 2 ): 289 - 309 .

ZMUDA JM , CAULEY JA , KRISKA A , et al . Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men. A 13-year follow-up of former Multiple Risk Factor Intervention Trial participants [J ] . Am J Epidemiol , 1997 , 146 ( 8 ): 609 - 617 .

程皓洋 , 张小燕 , 罗成龙 , 等 . 从勃起不同阶段探讨男性勃起功能障碍的中西医精准辨治思路 [J ] . 北京中医药 , 2024 , 43 ( 6 ): 680 - 683 .

李东垣 . 脾胃论中医古籍 [M ] . 北京 : 中国中医药出版社 , 2007 : 4 .

胡慎柔 . 慎柔五书中医各科 [M ] . 北京 : 中国中医药出版社 , 2011 : 43 .

孟湧生 , 杨振威 , 古楠 , 等 . 脾胃病变与中风病的关系探讨 [J ] . 中西医结合心脑血管病杂志 , 2016 , 14 ( 14 ): 1679 - 1681 .

杨良俊 , 刘伟 , 胡志鹏 , 等 . 基于脾胃理论探讨脾气虚病机与细胞自噬功能紊乱的相关性 [J ] . 南京中医药大学学报 , 2019 , 35 ( 1 ): 5 - 8 .

FRISARD MI , BROUSSARD A , DAVIES SS , et al . Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging Study [J ] . J Gerontol A Biol Sci Med Sci , 2007 , 62 ( 7 ): 752 - 759 .

KAWAI T , AUTIERI MV , SCALIA R . Adipose tissue inflammation and metabolic dysfunction in obesity [J ] . Am J Physiol Cell Physiol , 2021 , 320 ( 3 ): C375 - C391 .

STOUT MB , JUSTICE JN , NICKLAS BJ , et al . Physiological aging: links among adipose tissue dysfunction, diabetes, and frailty [J ] . Physiology (Bethesda) , 2017 , 32 ( 1 ): 9 - 19 .

张志聪 . 黄帝内经灵枢集注 [M ] . 北京 : 中医古籍出版社 , 2012 : 10 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰

Differentiation and treatment of late-onset hypogonadism based on the theory of "decline of Yangming meridian-kidney qi deficiency"

DOI：10.16025/j.1674-1307.2025.06.022

摘要

Abstract

关键词

Keywords

references