TCM and Western medicine clinical characteristics of rapidly progressing idiopathic inflammatory myopathy with interstitial lung disease

ZHANG Zongzue; WANG Yuguang; GUO Liya; LIU Xitong; WANG Ya'nan; MENG Guangsong

doi:10.16025/j.1674-1307.2025.08.004

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TCM and Western medicine clinical characteristics of rapidly progressing idiopathic inflammatory myopathy with interstitial lung disease

更新时间：2025-10-10

- TCM and Western medicine clinical characteristics of rapidly progressing idiopathic inflammatory myopathy with interstitial lung disease
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 8, Pages: 967-970(2025)
- 作者机构：
  
  首都医科大学附属北京中医医院呼吸科，北京 100010
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.08.004
  CLC：
- Received：15 April 2025，
  
  Published：25 August 2025
- 稿件说明：
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张宗学，王玉光，郭丽娅，等.快速进展型特发性炎症性肌病继发间质性肺疾病的中西医临床特征分析［J］.北京中医药，2025，44（8）：967-970.

ZHANG Zongzue,WANG Yuguang,GUO Liya,et al.TCM and Western medicine clinical characteristics of rapidly progressing idiopathic inflammatory myopathy with interstitial lung disease[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(08):967-970.
张宗学，王玉光，郭丽娅，等.快速进展型特发性炎症性肌病继发间质性肺疾病的中西医临床特征分析［J］.北京中医药，2025，44（8）：967-970. DOI： 10.16025/j.1674-1307.2025.08.004.

ZHANG Zongzue,WANG Yuguang,GUO Liya,et al.TCM and Western medicine clinical characteristics of rapidly progressing idiopathic inflammatory myopathy with interstitial lung disease[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(08):967-970. DOI： 10.16025/j.1674-1307.2025.08.004.

摘要

目的

分析快速进展型特发性炎症性肌病继发间质性肺疾病（idiopathic inflammatory myopathy associated interstitial lung disease，IIM-ILD）的中西医临床特征。

方法

本研究采用回顾性病例对照研究，选取首都医科大学附属北京中医医院2016年1月―2023年1月诊断为快速进展型IIM-ILD患者36例，收集和分析包括人口学信息、病程、临床表现或并发症、实验室检查结果、影像学资料、中医证候特点及短期预后等数据。选择稳定期IIM-ILD患者作为对照组，根据年龄和性别按1∶2的比例匹配病例资料。归纳总结快速进展型IIM-ILD患者的中医证候特点，评估短期预后不良的危险因素。

结果

快速进展型IIM-ILD患者的中医辨证分型实证以湿热蕴肺，湿热内蕴、扰及营血及肺气痹阻为主，虚证表现中喘脱占比最高。抗MDA5抗体阳性（

=0.008）是快速进展IIM-ILD患者短期预后不良的危险因素。

结论

抗MDA5抗体阳性是快速进展型IIM-ILD患者短期预后不良的危险因素，与较高死亡率相关。

Abstract

Objective

To analyze the clinical characteristics of rapidly progressing idiopathic inflammatory myopathy associated with interstitial lung disease （IIM-ILD） from both traditional Chinese medicine （TCM） and Western medicine perspectives.

Methods

This retrospective case-control study included 36 patients diagnosed with rapidly progressing IIM-ILD at Beijing Hospital of Traditional Chinese Medicine， Capital Medical University， from January 2016 to January 2023. Data collected and analyzed included demographic information， disease course， clinical manifestations or complications， laboratory test results， imaging findings， TCM syndrome characteristics， and short-term prognosis. Stable IIM-ILD patients were selected as the control group， matched by age and sex in a 1：2 ratio. The TCM syndrome characteristics of rapidly progressing IIM-ILD were summarized， and risk factors for poor short-term prognosis were evaluated.

Results

In TCM syndrome differentiation， the excess syndromes of rapidly progressing IIM-ILD were mainly characterized by dampness-heat accumulation in the lungs， dampness-heat retention， disturbance of nutrient blood， and obstruction of lung

. Among deficiency syndromes， asthma collapse accounted for the highest proportion. Positive anti-MDA5 antibody （

=0.008） was identified as a risk factor for poor short-term prognosis in patients with rapidly progressing IIM-ILD.

Conclusion

Rapidly progressing IIM-ILD is characterized by a lower oxygenation index and higher ferritin levels. Positive anti-MDA5 antibody is a risk factor for poor short-term prognosis. In TCM syndrome differentiation of rapidly progressing IIM-ILD， dampness-heat accumulation in the lungs is the predominant excess syndrome， while asthma collapse is the most frequent deficiency syndrome.

关键词

Keywords

references

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