Relationship between brain-thyroid-gut axis and pathogenesis of ulcerative colitis complicated with anxiety and depression based on the theories of <italic style="font-style: italic">zangfu</italic> organs, meridians, and collaterals

ZHANG Xinjie; WANG Yifei; ZHANG Shuxin

doi:10.16025/j.1674-1307.2025.08.021

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Relationship between brain-thyroid-gut axis and pathogenesis of ulcerative colitis complicated with anxiety and depression based on the theories of zangfu organs, meridians, and collaterals

更新时间：2025-10-10

- Relationship between brain-thyroid-gut axis and pathogenesis of ulcerative colitis complicated with anxiety and depression based on the theories of zangfu organs, meridians, and collaterals
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 8, Pages: 1048-1051(2025)
- 作者机构：
  
  北京中医药大学东直门医院肛肠科一区，北京 100700
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.08.021
  CLC：
- Received：28 September 2024，
  
  Published：25 August 2025
- 稿件说明：
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张新杰，王怡菲，张书信.脏腑经络学说探讨脑-甲状腺-肠轴与溃疡性结肠炎合并焦虑抑郁发病的关系［J］.北京中医药，2025，44（8）：1048-1051.

ZHANG Xinjie,WANG Yifei,ZHANG Shuxin.Relationship between brain-thyroid-gut axis and pathogenesis of ulcerative colitis complicated with anxiety and depression based on the theories of zangfu organs, meridians, and collaterals[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(08):1048-1051.
张新杰，王怡菲，张书信.脏腑经络学说探讨脑-甲状腺-肠轴与溃疡性结肠炎合并焦虑抑郁发病的关系［J］.北京中医药，2025，44（8）：1048-1051. DOI： 10.16025/j.1674-1307.2025.08.021.

ZHANG Xinjie,WANG Yifei,ZHANG Shuxin.Relationship between brain-thyroid-gut axis and pathogenesis of ulcerative colitis complicated with anxiety and depression based on the theories of zangfu organs, meridians, and collaterals[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(08):1048-1051. DOI： 10.16025/j.1674-1307.2025.08.021.

摘要

溃疡性结肠炎（ulcerative colitis，UC）以反复发作-缓解的结直肠炎症为特征，其疾病活动性与患者的精神状态密切相关。脑、甲状腺及肠通过免疫反应、肠道菌群以及代谢物相互影响。UC患者湿热蕴结大肠或久痢大肠虚寒，通降功能受损，气机不畅，“脑-甲状腺-肠”轴失衡，脑髓失养，甲状腺疏泄受阻，继发焦虑抑郁。经络沟通内外，联系表里，可用于解释脑-甲状腺-肠轴在UC合并焦虑抑郁中的联系与作用，其中足阳明胃经、足厥阴肝经与UC合并焦虑抑郁关系最为密切。由此得出UC合并焦虑抑郁患者的治法为清利阳明、疏泄气机。针刺需分经辨证，可重点选择足阳明胃经与足厥阴肝经，注意使用配穴，可提高临床疗效。

Abstract

Ulcerative colitis （UC） is characterized by recurrent and remitting inflammation in the colon and rectum， and its disease activity is closely related to the patient's mental state. The brain， thyroid， and gut interact through immune responses， intestinal flora， and metabolites. In UC patients， dampness-heat accumulates in the large intestine or chronic diarrhea leads to deficiency and cold in the large intestine， impairing the function of downward movement and

flow， which results in an imbalance of the "brain-thyroid-gut" axis. This causes malnourishment of the brain marrow， blockage of the thyroid's function in regulating

， and the subsequent development of anxiety and depression. Meridians and collaterals connect the internal and external as well as the exterior and interior， and can explain the connection and role of the "brain-thyroid-gut" axis in UC combined with anxiety and depression. Among them， the foot

yangming

stomach meridian and foot

jueyin

liver meridian are most closely related to UC combined with anxiety and depression. Therefore， the treatment for UC patients with anxiety and depression is to clear and promote the

yangming

meridian and regulate

movement. Acupuncture should be based on syndrome differentiation according to the meri

dians， with a focus on selecting the foot

yangming

stomach meridian and foot

jueyin

liver meridian， while paying attention to the use of adjunct points to improve clinical efficacy.

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references

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Relationship between brain-thyroid-gut axis and pathogenesis of ulcerative colitis complicated with anxiety and depression based on the theories of zangfu organs, meridians, and collaterals

DOI：10.16025/j.1674-1307.2025.08.021

摘要

Abstract

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