Effects of <italic style="font-style: italic">Xiaozhang Paste</italic> on <italic style="font-style: italic">Shenque</italic> on inflammatory reaction, coagulation function, and intestinal mucosal injury in septic rats

WANG Yinghui; QI Wensheng; JI Ran; MA Shizheng; JIANG Zongchen; ZHAO Xin; YU Daxing; LIU Chang

doi:10.16025/j.1674-1307.2025.12.008

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Effects of Xiaozhang Paste on Shenque on inflammatory reaction, coagulation function, and intestinal mucosal injury in septic rats

更新时间：2026-01-24

- Effects of Xiaozhang Paste on Shenque on inflammatory reaction, coagulation function, and intestinal mucosal injury in septic rats
- Beijing Journal of Traditional Chinese Medicine Vol. 44, Issue 12, Pages: 1549-1552(2025)
- 作者机构：
  
  中国中医科学院广安门医院急诊科，北京 100053
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2025.12.008
  CLC：
- Received：20 August 2024，
  
  Published：25 December 2025
- 稿件说明：
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王颖辉，齐文升，季然，等.消胀贴神阙穴贴敷对脓毒症大鼠炎症反应、凝血功能及肠道黏膜损伤的影响［J］.北京中医药，2025，44（12）：1549-1552.

WANG Yinghui,QI Wensheng,JI Ran,et al.Effects of Xiaozhang Paste on Shenque on inflammatory reaction, coagulation function, and intestinal mucosal injury in septic rats[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(12):1549-1552.
王颖辉，齐文升，季然，等.消胀贴神阙穴贴敷对脓毒症大鼠炎症反应、凝血功能及肠道黏膜损伤的影响［J］.北京中医药，2025，44（12）：1549-1552. DOI： 10.16025/j.1674-1307.2025.12.008.

WANG Yinghui,QI Wensheng,JI Ran,et al.Effects of Xiaozhang Paste on Shenque on inflammatory reaction, coagulation function, and intestinal mucosal injury in septic rats[J]. Beijing Journal of Traditional Chinese Medicine,2025,44(12):1549-1552. DOI： 10.16025/j.1674-1307.2025.12.008.

摘要

目的

观察消胀贴神阙穴贴敷对脓毒症大鼠炎症反应、凝血功能及肠道黏膜损伤的影响。

方法

将60只大鼠采用随机数字表法分为空白对照组、模型组、中药低剂量组、中药中剂量组和中药高剂量组，每组12只。除空白对照组外，其他各组制备脓毒症大鼠模型。所有大鼠腹部备皮，中药组分别予高、中、低剂量消胀贴贴敷神阙穴，模型组、空白对照组分别用淀粉调糊贴敷神阙穴，每24 h更换1次，连续贴敷72 h。对比各组大鼠一般情况，炎症介质肿瘤坏死因子α（TNF-α）、白细胞介素1β（IL-1β）及白细胞介素6（IL-6）水平，活化部分凝血活酶时间（APTT），以及肠组织病理变化。

结果

中药组大鼠死亡率低于模型组，中药剂量越高，大鼠死亡率越低。与对照组比较，模型组TNF-α、IL-1β、IL-6水平高（

0.01），APTT长（

0.01），大鼠肠组织病理变化评分高（

0.01）；与模型组比较，各中药组TNF-α、IL-1β、IL-6水平低（

0.01），APTT缩短（

0.05），大鼠肠组织病理变化评分低（

0.05）。

结论

消胀贴神阙穴贴敷可减轻脓毒症大鼠炎症反应，改善凝血功能，减轻肠道黏膜病理损伤。

Abstract

Objective

To observe the effects of

Xiaozhang Paste

Shenque

on inflammatory response， coagulation function， and intestinal mucosal injury in septic rats.

Methods

Sixty rats were randomly divided into five groups （

=12 each） using a random number table， including blank control group， model group， low-dose

Xiaozhang Paste

group， medium-dose

Xiaozhang Paste

group， and high-dose

Xiaozhang Paste

group. Sepsis was induced in all groups except the blank control group. All rats were shaved on the abdomen， and

Xiaozhang Paste

was applied to the

Shenque

acupoint at low， medium， and high doses in the corresponding groups. The model and blank control groups received a starch paste applied to the

Shenque

acupoint. Paste was replaced every 24 hours for a total of 72 hours. General condition， serum levels of tumor necrosis factor-α （TNF-α）， interleukin-1β （IL-1β）， interleukin-6 （IL-6）， activated partial thromboplastin time （APTT）， and pathological changes in intestinal tissue were compared among groups.

Results

The mortality of rats in the

Xiaozhang Paste

groups was lower than that in the model group， with higher doses corresponding to lower mortality. Compared with the blank control group， the model group showed significantly higher TNF-α， IL-1β， IL-6 levels （

0.01）， prolonged APTT

（

0.01）， and higher intestinal pathological scores （

0.01）. Compared with the model group， all

Xiaozhang Paste

groups had significantly lower TNF-α， IL-1β， IL-6 levels （

0.01）， shorter APTT （

0.05）， and lower intestinal pathological scores （

0.05）.

Conclusion

Xiaozhang Paste

Shenque

can reduce inflammatory responses， improve coagulation function， and alleviate intestinal mucosal injury in septic rats.

关键词

Keywords

references

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GIAMARELLOS-BOURBOULIS EJ , ASCHENBRENNER AC , BAUER M , et al . The pathophysiology of sepsis and precision-medicine-based immunotherapy [J ] . Nat Immunol , 2024 , 25 ( 1 ): 19 - 28 .

上海市中西医结合学会急救专业委员会 , 上海市中西医结合学会重症医学专业委员会 , 上海市医师协会急诊科医师分会 , 等 . 脓毒症急性胃肠功能障碍中西医结合临床专家共识 [J ] . 中华危重病急救医学 , 2022 , 34 ( 2 ): 113 - 120 .

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陈怡慧，董鹏，张喜洋 . 促炎细胞因子在脓毒症中作用的研究进展 [J ] . 中华危重病急救医学， 2023 ， 35 ( 2 ): 212 - 216 .

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⁰

Effects of Xiaozhang Paste on Shenque on inflammatory reaction, coagulation function, and intestinal mucosal injury in septic rats

DOI：10.16025/j.1674-1307.2025.12.008

摘要

Abstract

关键词

Keywords

references