Objective

2

To observe the in vitro antibacterial effects of

Qingre Chushi Decoction

（QRCSD） and

Chushi Zhiyang Decoction

（CSZYD） in patients with eczema complicated by bacterial infections.

Methods

2

Pathogenic bacteria were isolated from skin lesion secretions of eczema patients with bacterial infections at the Dermatology Department of Beijing Hospital of Traditional Chinese Medicine， Capital Medical University， from July 2023 to June 2024. The minimum inhibitory concentrations （MICs） of QRCSD and CSZYD against the ten most frequently isolated pathogens were determined using the broth microdilution method. Based on these results， individual herbal components were further tested for their MICs.

Results

2

Among 412 pathogenic strains in patients with eczema complicated by bacterial infections，

Staphylococcus

species were the most prevalent （

S.aureus

39.81%，

S.epidermidis

29.85%）. Broth microdi

lution assays showed that QRCSD exhibited broad-spectrum antibacterial activity against

Staphylococcus

spp

.， with the lowest MIC observed for

S. capitis

（15.625 mg/mL）. The MICs for

S. aureus

（including MRSA），

S. epidermidis

（including MRSE）， and

S. hominis

were 31.25 mg/mL， while

S. haemolyticus

and

S. warneri

had MICs of 62.5 mg/mL. In contrast， CSZYD inhibited only

S. capitis

（MIC=62.5 mg/mL） and

S. haemolyticus

（MIC=125 mg/mL）. Among individual herbs in QRCSD，

Scutellariae Radix

showed MICs

<

3.906 mg/mL against all tested

Staphylococcus

species.

Conclusion

2

QRCSD demonstrates stronger

in vitro

antibacterial activity than CSZYD in eczema patients with bacterial infections， with

Scutellariae Radix

likely being the key active component.