Retrospective study on the treatment of persistent primary immune thrombocytopenia with <italic style="font-style: italic">Jinjuan Shengban formula</italic>

LIU Qingchi; YIN Wanyi; MA Bing; ZHANG Lihong; ZHAO Dan; LI Yuexian; WANG Jianying; LIU Xinying; SHEN Xiaofang; REN Xinyi; SHENG Yang; ZHANG Huimin

doi:10.16025/j.1674-1307.2026.03.006

您当前的位置：

首页 >

文章列表页 >

Retrospective study on the treatment of persistent primary immune thrombocytopenia with Jinjuan Shengban formula

更新时间：2026-06-02

- Retrospective study on the treatment of persistent primary immune thrombocytopenia with Jinjuan Shengban formula
- Beijing Journal of Traditional Chinese Medicine Vol. 45, Issue 3, Pages: 317-321(2026)
- 作者机构：
  
  1.河北医科大学第一医院血液内科，石家庄 050031
  2.北京航天七三一医院，北京100074
  3.衡水市人民医院，衡水 053099
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2026.03.006
  CLC：
- Received：13 November 2024，
  
  Published：25 March 2026
- 稿件说明：
移动端阅览
刘清池，尹婉宜，马兵，等.金卷升板方治疗持续性原发免疫性血小板减少症回顾性研究［J］.北京中医药，2026，45（3）：317-321.

LIU Qingchi,YIN Wanyi,MA Bing,et al.Retrospective study on the treatment of persistent primary immune thrombocytopenia with Jinjuan Shengban formula[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(03):317-321.
刘清池，尹婉宜，马兵，等.金卷升板方治疗持续性原发免疫性血小板减少症回顾性研究［J］.北京中医药，2026，45（3）：317-321. DOI： 10.16025/j.1674-1307.2026.03.006.

LIU Qingchi,YIN Wanyi,MA Bing,et al.Retrospective study on the treatment of persistent primary immune thrombocytopenia with Jinjuan Shengban formula[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(03):317-321. DOI： 10.16025/j.1674-1307.2026.03.006.

摘要

目的

观察金卷升板方治疗持续性原发免疫性血小板减少症（ITP）的临床疗效与安全性。

方法

选择2016年6月—2022年6月在河北医科大学第一医院门诊采用金卷升板方治疗的70例持续性ITP患者为观察组，选取同期性别与年龄相匹配的采用糖皮质激素甲泼尼龙治疗的30例持续性ITP患者作为对照组。回顾性分析2组患者的临床疗效和不良反应发生情况。

结果

观察组70例，达完全反应（CR）32例（45.7%），有效（R）30例（42.8%），无效（NR）8例（11.4%），总有效率88.6%（62/70），持续有效（DR）62例（88.6%），达缓解（Rem）56例（80.0%），复发（Rel）8例（8/62，12.9%）。对照组30例，达CR 17例（56.7%），R 8例（26.7%），NR 5例（16.7%），总有效率83.3%（25/30），DR 2例（6.7%），Rem 1例（3.3%），Rel 21例（

21/25，84.0%）。观察组与对照组总有效率比较，差异无统计学意义（

=0.523），观察组DR率高于对照组（

=0.000），Rel率低于对照组（

0.001），观察组早期反应（ER）0/70、初步反应（IR）8/70，均低于对照组（ER 5/30、IR 18/30），差异有统计学意义（

=0.027

，P

=0.000）。血小板抗体阴性与阳性患者的总有效率比较，观察组为80.0% vs 86.8%（

=0.849），对照组为100% vs 75%（

=0.285）。观察组常见的不良反应为轻微的胃肠道反应，对照组不良反应为血糖升高、血压升高、下肢水肿等。

结论

金卷升板方治疗持续性ITP有较好的远期临床疗效，复发率低，不良反应较轻，而甲泼尼龙治疗持续性ITP见效快，但远期疗效较差，复发率高，不良反应明显。

Abstract

Objective

To observe the clinical efficacy and safety of the

Jinjuan Shengban formula

in the treatment of persistent primary immune thrombocytopenia （ITP）.

Methods

A retrospective analysis was conducted on 70 patients with persistent ITP treated with the

Jinjuan Shengban formula

in the outpatient department of the First Hospital of Hebei Medical University from June 2016 to June 2022， serving as the observation group. In addition， 30 patients with persistent ITP treated with glucocorticoid methylprednisolone during the same period and matched for sex and age were selected as the control group. Clinical efficacy and adverse reactions were observed in both groups.

Result

In the observation group （

= 70）， 32 cases （45.7%） achieved complete response （CR）， 30 cases （42.8%） showed response （R）， and 8 cases （11.4%） showed no response （NR）， with a total response rate of 88.6% （62/70）. Among responders， 62 cases （88.6%） achieved sustained efficacy （DR）， 56 cases achieved remission （Rem， 80.0%）， and 8 cases relapsed （Rel， 8/62， 12.9%）.In the control group （

= 30）， 17 cases （56.7%） achieved CR， 8 cases （26.7%） showed R， and 5 cases （16.7%） showed NR， with a total response rate of 83.3% （25/30）. Among responders， 2 cases （6.7%） achieved DR， 1 case achieved Rem （3.3%）， a

nd 21 cases Rel （21/25， 84.0%）. There was no statistically significant difference in total response rate between the two groups （

=0.523）. The sustained DR in the observation group was significantly higher than that in the control group （

= 0.000）， while the Rel in the observation group was significantly lower than that in the control group （

0.001）. Early response （ER： 0/70） and initial response （IR： 8/70） in the observation group were lower than those in the control group （ER： 5/30； IR： 18/30）， with statistically significant differences （

=0.027，

=0.000）. There was no statistically significant difference in efficacy between platelet antibody-negative and -positive patients in the observation group （80% vs. 86.8%，

=0.849） or in the control group （100% vs. 75%，

=0.285）. The main adverse reactions in the observation group were mild gastrointestinal symptoms. In the control group， adverse reactions included elevated blood glucose， elevated blood pressure， and lower limb edema.

Conclusion

The

Jinjuan Shengban formula

demonstrates favorable long-term efficacy in the treatment of persistent ITP， with a low relapse rate and mild adverse reactions. Methylprednisolone shows a rapid onset of effect but poorer long-term efficacy， a higher relapse rate， and more significant adverse reactions.

关键词

Keywords

references

SUN M , WANG X , WANG L , et al . The role of follicular regulatory T cells/follicular helper T cells in primary immune thrombocytopenia [J ] . Acta Haematol , 2023 , 146 ( 4 ): 267 - 276 .

ALTHAUS K , FAUL C , BAKCHOUL T . New developments in the pathophysiology and management of primary immune thrombocytopenia [J ] . Hamostaseologie , 2021 , 41 ( 4 ): 275 - 282 .

AUDIA S , MAHÉVAS M , NIVET M , et al . Immune thrombocytopenia: recent advances in pathogenesis and treatments [J ] . Hemasphere , 2021 , 5 ( 6 ): e574 .

HATO T , SHIMADA N , KURATA Y , et al . Risk factors for skin, mucosal, and organ bleeding in adults with primary ITP: a nationwide study in Japan [J ] . Blood Adv , 2020 , 4 ( 8 ): 1648 - 1655 .

ROVÓ A , CANTONI N , SAMII K , et al . Real-world impact of primary immune thrombocytopenia and treatment with thrombopoietin receptor agonists on quality of life based on patient-reported experience: results from a questionnaire conducted in Switzerland, Austria, and Belgium [J ] . PLoS One , 2022 , 17 ( 4 ): e0267342 .

SANDAL R , MISHRA K , JANDIAL A , et al . Update on diagnosis and treatment of immune thrombocytopenia [J ] . Expert Rev Clin Pharmacol , 2021 , 14 ( 5 ): 553 - 568 .

NEUNERT C , TERRELL DR , ARNOLD DM , et al . American society of hematology 2019 guidelines for immune thrombocytopenia [J ] . Blood Adv , 2019 , 3 ( 23 ): 3829 - 3866 .

王茹婷 , 刘新光 , 侯宇 , 等 . 一项针对原发免疫性血小板减少症的医患调研：I-WISh国际调研中国亚组分析 [J ] . 中华血液学杂志 , 2021 , 42 ( 5 ): 369 - 375 .

刘清池 , 吴维海 , 梁春耕 , 等 . 凉血解毒法治疗原发性免疫性血小板减少症的临床研究 [J ] . 世界中西医结合杂志 , 2012 , 7 ( 11 ): 955 - 958 .

郎海燕 , 董石 , 马薇 , 等 . 中医药治疗难治性原发免疫性血小板减少症的现状及问题 [J ] . 北京中医药 , 2023 , 42 ( 6 ): 580 - 584 .

中华医学会血液学分会血栓与止血学组 . 成人原发免疫性血小板减少症诊断与治疗中国指南（2020年版） [J ] . 中华血液学杂志 , 2020 , 41 ( 8 ): 617 - 623 .

中国儿童原发性免疫性血小板减少症诊断与治疗指南改编工作组 , 中华医学会儿科学分会血液学组 , 中华儿科杂志编辑委员会 . 中国儿童原发性免疫性血小板减少症诊断与治疗改编指南（2021版） [J ] . 中华儿科杂志 , 2021 , 59 ( 10 ): 810 - 819 .

侯明 . 免疫性血小板减少症 [M ] //王建祥，肖志坚，沈志祥，等. 邓家栋临床血液学 . 2版上海 : 上海世纪出版（集团）出版有限公司， 2020 : 1048 .

NOKHOSTIN F , BAKHSHPOUR F , PEZESHKI S , et al . Immune thrombocytopenia: a review on the pathogenetic role of immune cells [J ] . Expert Rev Hematol , 2023 , 16 ( 10 ): 731 - 742 .

刘清池 . 从火气失常论治原发免疫性血小板减少症 [J ] . 北京中医药 , 2023 , 42 ( 6 ): 592 - 595 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical treatment of Crohn's disease based on Treatise on Cold Damage and Miscellaneous Diseases

Differentiating and treating hepatogenic fatigue based on the theory of "yin in property and yang in function of liver"

Preliminary exploration of the experience in differentiating and treating Hailey-Hailey disease based on the theory of "healthy qi deficiency and latent pathogens"

Pathogenesis and treatment of functional impotence based on the theory of "unity of form and spirit"

Outcomes indicators in randomized controlled trials of traditional Chinese medicine for postinfectious cough

Related Author

No data

Related Institution

No data

⁰

Retrospective study on the treatment of persistent primary immune thrombocytopenia with Jinjuan Shengban formula

DOI：10.16025/j.1674-1307.2026.03.006

摘要

Abstract

关键词

Keywords

references