Application discussion of ZHANG Bing's tripartite syndrome differentiation model integrating "syndrome-symptom-drug" in metabolic comorbidity

BAI Hua; ZHANG Bing

doi:10.16025/j.1674-1307.2026.04.010

您当前的位置：

首页 >

文章列表页 >

Application discussion of ZHANG Bing's tripartite syndrome differentiation model integrating "syndrome-symptom-drug" in metabolic comorbidity

更新时间：2026-06-10

- Application discussion of ZHANG Bing's tripartite syndrome differentiation model integrating "syndrome-symptom-drug" in metabolic comorbidity
- Beijing Journal of Traditional Chinese Medicine Vol. 45, Issue 4, Pages: 479-484(2026)
- 作者机构：
  
  1.北京中医药大学东方医院，北京 100078
  2.北京中医药大学，北京 100029
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2026.04.010
  CLC：
- Received：21 July 2025，
  
  Published：25 April 2026
- 稿件说明：
移动端阅览
白桦，张冰.张冰“证-症-药”三位一体整合论证模式在代谢性共病中的应用探讨［J］.北京中医药，2026，45（4）：479-484.

BAI Hua,ZHANG Bing.Application discussion of ZHANG Bing's tripartite syndrome differentiation model integrating "syndrome-symptom-drug" in metabolic comorbidity[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(04):479-484.
白桦，张冰.张冰“证-症-药”三位一体整合论证模式在代谢性共病中的应用探讨［J］.北京中医药，2026，45（4）：479-484. DOI： 10.16025/j.1674-1307.2026.04.010.

BAI Hua,ZHANG Bing.Application discussion of ZHANG Bing's tripartite syndrome differentiation model integrating "syndrome-symptom-drug" in metabolic comorbidity[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(04):479-484. DOI： 10.16025/j.1674-1307.2026.04.010.

摘要

代谢性共病是全球重大公共卫生挑战，张冰教授基于丰富的临床实践，构建并践行“证-症-药”三位一体的诊疗模式。该模式以“医药合参”为核心理念，针对代谢性共病虚、湿、浊、瘀、毒多种致病因素交织的特点，通过多维整合病、证、症信息，以固本（健脾、益肾、疏肝）祛邪（化浊、祛瘀、解毒）为纲，巧用多效药配伍，从而改善机体代谢，维护内环境稳态，充分体现异病同治、整合论治的理念，实现代谢性共病的精准施治。

Abstract

Metabolic comorbidity has become a major global public health challenge. Based on extensive clinical practice， Professor ZHANG Bing has established and implemented a tripartite diagnostic and therapeutic model integrating "syndrome-symptom-drug" principles. Centered on the core concept of integrating medical theory with pharmacological application， this model targets the complex interplay of deficiency， dampness， turbidity， blood stasis， and toxins in metabolic comorbidity. By systematically integrating multidimensional information on diseases， syndromes， and symptoms， the model emphasizes both strengthening healthy

and eliminating pathogenic factors， with therapeutic strategies focused on strengthening the spleen， tonifying the kidney， soothing the liver， resolving turbidity， removing blood stasis， and detoxifying. Through the skillful combination of multifunctional herbal medicines， the model aims to improve metabolic function and maintain internal homeostasis. It fully embodies the clinical concepts of treating different diseases with the same therapeutic approach and integrated syndrome differentiation， thereby achieving precise treatment of metabolic comorbidity.

关键词

Keywords

references

李永军 , 李艳 , 冯桂波 , 等 . 三级医院全科医学科中老年住院患者慢性病共病现状及影响因素 [J ] . 保健医学研究与实践 , 2024 , 21 ( 7 ): 20 - 26 .

张爽 , 彭年春 , 胡颖 . 内脏脂肪代谢评分与代谢综合征及其相关并发症关系的研究进展 [J ] . 疑难病杂志 , 2025 , 24 ( 5 ): 636 - 640 .

郭佩 , 李春君 , 张莉 , 等 . 天津市成人代谢性疾病共病患病率及其影响因素 [J ] . 职业与健康 , 2021 , 37 ( 22 ): 3061 - 3066，3071 .

NICHOLSON K , ALMIRALL J , FORTIN M . The measurement of multimorbidity [J ] . Health Psychol , 2019 , 38 ( 9 ): 783 - 790 .

匡家奇 , 章素秀 , 江晗 , 等 . 活体生物药在代谢类疾病中的研究 [J/OL ] . 合成生物学 , 1 - 17 [ 2025-10-16 ] . https://doi.org/10.12211/2096-8280.2025-024 https://doi.org/10.12211/2096-8280.2025-024 .

FARMER C , FENU E , O'FLYNN N , et al . Clinical assessment and management of multimorbidity: summary of NICE guidance [J ] . BMJ , 2016 , 354 : i4843 .

聂亦然 , 罗欢 , 姜磊 , 等 . 基于《伤寒论》与临床数据挖掘的“病-证-方”知识获取模型研究 [J ] . 江西中医药大学学报 , 2025 , 37 ( 3 ): 40 - 47,52 .

刘萍 . 对合理用药中药物相互作用的现状及对策研究 [D ] . 沈阳 : 沈阳药科大学 . 2008 .

王琦 . 中医体质学对共病诊疗的理论创新与实践 [J/OL ] . 北京中医药大学学报 , 1 - 13 [ 2025-10-16 ] . https://link.cnki.net/urlid/11.3574.r.20250626.1739.006 https://link.cnki.net/urlid/11.3574.r.20250626.1739.006 .

刘爽 . 中医优势病种全流程诊疗信息基本数据集的构建及应用研究 [D ] . 北京 : 中国中医科学院 , 2024 .

王茜 , 张冰 . 张冰教授安全用药临床路径探析 [J ] . 中国医药导报 , 2021 , 18 ( 19 ): 134 - 137 .

李妍芃 , 闫玉琴 , 周晟芳 , 等 . 张冰临床用药告知内涵及规程研究 [J ] . 北京中医药 , 2023 , 42 ( 1 ): 55 - 58 .

张春和 , 赵凡 , 马利民 , 等 . 重视“异病同治”理论在泌尿男科领域的应用 [J ] . 中国男科学杂志 , 2025 , 39 ( 1 ): 3 - 7，19 .

李秀月，代民涛，柴可夫．《金匮要略》同病异治和异病同治运用析述 [J ] ．中华中医药杂志 2017 , 32 ( 10 ): 4351 - 4354 .

张悦 , 张毅 , 李娟 , 等 . 经方组方特色与临证应用思路 [J ] . 陕西中医 , 2019 , 40 ( 11 ): 1630 - 1633 .

李文静 , 张晓朦 , 林志健 . “整合论治”策略下张冰教授标本兼治痛风病临床实践 [J ] . 世界中医药 , 2021 , 16 ( 1 ): 8 - 12 .

石琳 , 张冰 . 张冰从肝论治消化系统疾病的学术思想与临床经验 [J ] . 中华中医药杂志 , 2021 , 36 ( 5 ): 2737 - 2740 .

张媛凤 , 张冰 , 周伟龙 . 张冰运用“一毒三法”辨治寻常型银屑病经验撷萃 [J ] . 中华中医药杂志 , 2019 , 34 ( 1 ): 173 - 176 .

王冰 , 樊茂蓉 , 崔云 , 等 . 王书臣治疗肺系疾病对药应用经验撷英 [J ] . 北京中医药 , 2017 , 36 ( 12 ): 1124 - 1126 .

侯银静 , 秦明照 . 老年心血管疾病患者共病管理策略 [J ] . 中国临床保健杂志 , 2025 , 28 ( 2 ): 203 - 207 .

潘富阳 . 老年住院患者潜在不适当用药与共病严重程度的相关性研究 [D ] . 十堰 : 湖北医药学院 , 2023 .

张依娜 , 赵锋 , 唐瑜 , 等 . 中药通过AMPK信号通路防治高脂血症研究进展 [J ] . 中南药学 , 2025 , 23 ( 5 ): 1369 - 1376 .

HAWLEY SA , RUSSELL FM , HARDIE DG . AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand [J ] . Biochem J , 2024 , 481 ( 8 ): 587 - 599 .

LI J , LI S , WANG F , et al . Structural and biochemical insights into the allosteric activation mechanism of AMP-activated protein kinase [J ] . Chem Biol Drug Des , 2017 , 89 ( 5 ): 663 - 669 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

ZHANG Bing's clinical practice based on the concept of "medicine-pharmacy-humanities integration"

Differentiation and treatment of pulmonary nodules based on the theory of "membranous triple energizer" by CHEN Chaozu

CAI Lianxiang's experience in treating fat liquefaction of incision after gynecological abdominal surgical by "Tuobu method"

LYU Peiwen's clinical experience on differentiating sores and ulcers with true cold with false heat syndrome

LI Haisong's experience in treating chronic prostatitis with anxiety and depression from the perspectives of deficiency and blood stasis

Related Author

ZHANG Rui

ZHANG Bing

GONG Xuan

XIE Jiakang

ZENG Yunping

WU Siyue

LIAO Guoyang

YANG Yanling

Related Institution

Department of Respiratory Medicine， Beijing Xuanwu Traditional Chinese Medicine Hospital

School of Chinese Materia Medica， Beijing University of Chinese Medicine

Zhanjiang Second Hospital of Traditional Chinese Medicine， Guangzhou University of Chinese Medicine

College of Traditional Chinese Medicine， Jinan University

Department of Pulmonary Diseases， Zhanjiang Second Hospital of Traditional Chinese Medicine， Guangzhou University of Chinese Medicine

⁰