Preliminary exploration of the experience in differentiating and treating Hailey-Hailey disease based on the theory of "healthy <italic style="font-style: italic">qi </italic>deficiency and latent pathogens"

CHEN Jiaqi; XU Haonan; XUE Guohua; DAI Wei; ZHOU Dongmei

doi:10.16025/j.1674-1307.2026.04.022

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Preliminary exploration of the experience in differentiating and treating Hailey-Hailey disease based on the theory of "healthy qi deficiency and latent pathogens"

更新时间：2026-06-10

- Preliminary exploration of the experience in differentiating and treating Hailey-Hailey disease based on the theory of "healthy qi deficiency and latent pathogens"
- Beijing Journal of Traditional Chinese Medicine Vol. 45, Issue 4, Pages: 534-537(2026)
- 作者机构：
  
  1.首都医科大学附属北京中医医院皮肤科，北京100010
  2.北京中医药大学研究生院，北京 100029
- 作者简介：
- 基金信息：
- DOI：10.16025/j.1674-1307.2026.04.022
  CLC：
- Received：28 March 2025，
  
  Published：25 April 2026
- 稿件说明：
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陈佳祺，许浩南，薛国华，等.从正虚邪伏辨治慢性家族性良性天疱疮经验［J］.北京中医药，2026，45（4）：534-537.

CHEN Jiaqi,XU Haonan,XUE Guohua,et al.Preliminary exploration of the experience in differentiating and treating Hailey-Hailey disease based on the theory of "healthy qi deficiency and latent pathogens"[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(04):534-537.
陈佳祺，许浩南，薛国华，等.从正虚邪伏辨治慢性家族性良性天疱疮经验［J］.北京中医药，2026，45（4）：534-537. DOI： 10.16025/j.1674-1307.2026.04.022.

CHEN Jiaqi,XU Haonan,XUE Guohua,et al.Preliminary exploration of the experience in differentiating and treating Hailey-Hailey disease based on the theory of "healthy qi deficiency and latent pathogens"[J]. Beijing Journal of Traditional Chinese Medicine,2026,45(04):534-537. DOI： 10.16025/j.1674-1307.2026.04.022.

摘要

慢性家族性良性天疱疮是一种遗传相关的自身免疫性大疱病，皮疹呈现水疱、斑块、糜烂、渗出等多形态。本病好发于先天禀赋不耐、后天脾虚湿盛之人，以肺卫不固、肌肤失养为表象。初起内湿伏藏，隐而不发，后感四时之变、承五志过极，蕴而化热，积聚成毒，呈现水疱、糜烂、渗出之“湿毒态”，或肥厚、皲裂之“湿滞态”。该病急性期以湿、热、毒为标，易夹瘀、夹风，治以清热解毒、除湿通络，以祛邪外出；稳定期以脾肾两虚为本，健脾益肾助津液布散，以防复发。治疗应坚持中西互参，重视早期诊断及长期随访，灵活使用内外治法，以达到力坚而不峻猛，祛邪而不伤正之功效。

Abstract

Hailey-Hailey disease is a genetically related autoimmune blistering disease characterized by polymorphic skin lesions， including blisters， plaques， erosions， and exudation. This disease commonly occurs in individuals with congenital constitutional weakness and acquired spleen deficiency with excessive dampness， manifesting superficially as insecurity of lung-defensive

and malnourishment of the skin. In the early stage， in

ternal dampness remains latent and hidden without outward manifestation. Later， under the influence of seasonal climatic changes and excessive emotional disturbance， dampness accumulates and transforms into heat， eventually generating toxin， presenting as a "dampness-toxin pattern" characterized by blisters， erosions， and exudation， or a "dampness-retention pattern" characterized by hypertrophy and fissures. In the acute stage， dampness， heat， and toxin are the predominant manifestations and are often accompanied by blood stasis and wind pathogens. Treatment should focus on clearing heat and removing toxin， eliminating dampness and dredging the collaterals， so as to expel pathogenic factors outward. In the stable stage， spleen and kidney deficiency constitute the root pathogenesis， and treatment should focus on strengthening the spleen and replenishing the kidney to promote the distribution of body fluids and prevent recurrence. Treatment should integrate traditional Chinese and Western medicine， emphasize early diagnosis and long-term follow-up， and flexibly apply both internal and external therapies， so as to achieve therapeutic effects that are effective without being overly harsh and that eliminate pathogenic factors without damaging healthy

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Preliminary exploration of the experience in differentiating and treating Hailey-Hailey disease based on the theory of "healthy qi deficiency and latent pathogens"

DOI：10.16025/j.1674-1307.2026.04.022

摘要

Abstract

关键词

Keywords

references