摘要:Objective To observe and analyze the characteristics of TCM syndromes of influenza-like cases in Beijing from the end of2016 to early 2017. Methods A cross-sectional survey method was used to study 1 224 influenza-like cases received by Chaoyang Hospital affiliated to the Capital Medical University and another 4 hospitals from Nov. 2016 to Feb. 2017,and through analysis based on epidemiology,the clinical manifestations and laboratory test results,TCM syndrome characteristics of influenza-like cases in the Beijing area in winter and spring 2016/2017 were summarized. Results Of 1 224 influenza-like cases,there were fever( 97. 5%),Tmax( 38. 5 ± 0. 7) ℃ at the beginning with cough and sore throat as the main symptoms. On the visit to the clinic,there were fever,cough accompanied by body ache,running nose and sore throat. TCM syndromes were mainly characterized by wind and heat syndrome in 440 cases( 35. 9%),then wind cold syndrome and cold covering fire respectively in 335 cases( 27. 4%) and 300 cases( 24. 5%).There were 740 confirmed flu cases( 60. 5%) including 732 cases of swine flu( 59. 8%),seasonal H3 N2 swine flu( 54. 1%) was the major part among influenza pathogen A,but subtypes were extremely low. The percentage of neutrophils was slightly higher,and there was not much change compared with that in the past. Conclusion The winter and spring flu-like cases in Beijing from 2016 to 2017 were in line with the category of "wind febrile disease"in Chinese medicine accompanied with the clinical symptoms of simultaneous disorder of Defensive qi and qi.
摘要:Objective To explore the relationship between the number of influenza-like cases with the daily average temperature,daily maximum temperature,daily minimum temperature and daily temperature difference,as well as the relationship between the daily average temperature and TCM symptoms in Beijing in winter and spring of 2016/2017. Methods A cross-sectional survey method was used to collect the influenza-like illness numbers and TCM symptoms in outpatient clinics of 4 hospitals of Beijing from November 14,2016 to February 28,2017,the correlation between the number of their daily incidence and four temperature factors was analyzed respectively,and according to the daily average temperature changes,the cases were divided into rising daily average temperature group and declining daily average temperature group,Chi-square test was used to compare the difference of TCM symptoms between the two groups. Results A total of 1226 influenza-like cases were collected,of them,the male accounted for 45. 4%,the female for 54. 6%,and the age was 40. 0 ± 16. 3 years old including 740 positive cases( 60. 4%); there was negative relationship between the daily incidence and the daily average temperature,the daily maximum temperature,and daily minimum temperature,but positive relationship with the daily temperature difference,and there was no difference in TCM symptoms between TCM syndromes of influenza-like cases in rising daily average temperature group and declining daily average temperature group. Conclusion The number of influenza-like cases can be changed differently under the influence of temperature,it may be related to the changes of human activities caused by temperature changes; there is no obvious difference between the symptoms of influenzalike cases caused by rinsing and declining of daily average temperature as all of them have the syndromes of fever,cough and sore throat. The differentiation of it is wind-heat syndrome and falls into the category of "wind febrile".
摘要:<正>1993年Ramsay提出ICU获得性衰弱(intensive care unit acquired weekness,ICUAW)的概念,ICUAW是ICU患者常见的一种获得性神经肌肉功能障碍的疾病,又称ICU获得性肌无力、ICU获得性神经肌肉疾病、危重病性多发性神经肌病等。临床上根据累及部位的不同分为三类:危重病性
摘要:Objective To observe the clinical effects of Zhike Qingfei Decoction on acute cough of pathogenic dryness invading lung syndrome caused by acute tracheal bronchitis. Methods Randomized,paralleled and controlled methods were used to divide patients into experimental group and control group. The control group was given basic treatment and took orally Keyu Syrup,the treatment group was treated with the basic treatment and Zhike Qingfei Decoction taken orally,and the course was five days. The VAS scores of the two groups and the scores of cough and the total clinical effectiveness in and before and after treatment were observed. Results There were no statistical significance in difference among the VAS scores,daytime cough scores,night cough scores comparison between the two groups( P > 0. 05),they were all decreased compared with those before the treatment,the differences were statistically significant( P <0. 01,P < 0. 05),more obviously decreased in the experiment group than in the control group( P < 0. 01,P < 0. 05). To compare the total clinical effectiveness of two groups,the effective rate was 91. 7% in the experimental group and 79. 2% in the control group,and the difference was statistically significant( P < 0. 05). Conclusion Zhike Qingfei Decoction can effectively improve cough caused by acute tracheal bronchitis with good clinical effect.
摘要:Objective To observe and compare the characteristics of TCM syndromes and APACHE II scores with two mechanical ventilation modes,that is,non-invasive ventilation and invasive ventilation,in acute exacerbation of chronic obstructive pulmonary disease( COPD) in order to optimize the therapeutic regime and provide evidences for determining the severity and prognosis of the disease. Methods 59 cases of AECOPD in ICU of Wangjing Hospital,China Academy of Chinese Medical Sciences who received mechanical ventilation from June 2014 to June 2016 were divided into non-invasive ventilation group of 32 cases and invasive ventilation group of 27 cases,and TCM syndrome types and APACHE II scores were compared. Results There were 10 cases( 31. 3%) belonging to excess syndrome,14 cases( 43. 8%) belonging to deficiency syndrome,8 cases( 25. 0%) belonging to syndrome of intermingled deficiency and excess in the non-invasive ventilation group; and there were 5 cases( 18. 5%) of excess syndrome,6 cases( 22. 2%) of deficiency syndrome,16 cases( 59. 3%) of syndrome of intermingled deficiency and excess in the invasive ventilation group. APACHE II scores of invasive ventilation group were larger than that of the non-invasive ventilation group,and the difference was statistically significant( P < 0. 05). Conclusion Excess syndrome and deficiency syndrome are the majority in the non-invasive ventilation group,and especially lung qi deficiency is the most; while,intermingled deficiency and excess syndrome is the majority in the invasive ventilation group,and lung and spleen qi deficiency and phlegm covering the orifices are the most. Those with the scores above 22 may consider using invasive ventilation,while those with the scores under 15 choosing non-invasive ventilation.
摘要:Objective To explore Chinese herbal medicines for oral nursing on detection of sputum culture during ventilator treatment. Methods 141 cases of pneumonia patients using ventilator were divided into control group of 65 cases and experimental group of 76 cases. According to the differentiation of syndromes,the experiment group was given oral nursing with Chinese herbal medicines,for heat syndrome,Yinhua 30 g,Kushen 30 g,and Huangqin 30 g were prescribed and decocted deeply into 200 m L taken two times a day; for cold syndrome,Kushen 30 g,Shechuangzi 30 g,Ganjiang 30 g,and Gancao 30 g were used and deeply decocted into 200 m L. The control group received routine saline f or oral nursing. The positive condition of sputum culture of two groups before and after oral care with invasive ventilator and non-invasive ventilator were observed and compared. Results The rate of positive results of sputum culture before and after the treatment of oral nursing during invasive ventilation and non-invasive ventilation were 38. 46%and 36. 00% respectively in the experimental group,lower than that of the control group which were 100% and 100% respectively.And the differences were statistically significant( χ2= 31. 179,29. 568; P < 0. 01). Conclusion The Chinese herbal medicines for oral nursing can reduce the detection rate of sputum culture so as to prevent the occurrence of ventilator-associated pneumonia.
关键词:Chinese herbal medicines for oral nursing;ventilator-associated pneumonia;sputum culture;prevention with Chinese herbal medicine
摘要:Objective To investigate the expression of Caveolin-1( Cav-1) in the tongue tissues of rats with severe acute pancreatitis and the regulating action of Emodin on it. Methods Severe acute pancreatitis model was induced by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct. Male SD rats were randomly divided into model group of sham-operated group( SO),severe acute pancreatitis group( SAP),and Emodin-treated group( Emodin). After model establishment,Emodin was administrated orally in the Emodin group( 10 mg/kg/each time,twice a day),while an equal amount of normal saline was administrated in the SAP and SO group. 5 days after model establishment,analysis of histomorphology and expression of Cav-1 protein and mRNA were studied by Transmission Electron Microscope,Western-blot and Q-PCR using tongue tissues,which were collected from 8 sacrificed rats randomly chosen from each group. Results It was shown by Transmission Electron Microscope that pinocytosis bullules of vascular endothelial cell were more increased in the SAP group compared with the SO group,and fewer in the Emodin group. The expressions of Cav-1 and mRNA in the SAP group were increased compared with that of the SO group and the difference of expression was statistically significant( P < 0. 05). The expressions of Cav-1 and mRNA were significantly decreased in the Emodin group compared with the SAP group,and the difference of expression was statistically significant( P < 0. 05). Conclusion The expression of Cav-1 increases in SAP rats’ tongue tissues; and the intervention of Emodin can down-regulate the expression of Cav-1 and mRNA.
摘要:Objective To investigate the effects of Astragalus,Panax notoginseng and their compatibility on the expression of Gli1/2/3,SUFU and Cyclin D1 in precancerous lesions of gastric cancer( PLGC) rats. Methods Male Wistar rats were randomly divided into control group,model group,Astragalus group,Panax notoginseng group,Astragalus plus Panax notoginseng group,cyclopamine group,Purmorphamine group and folic acid group of 10 each. PLGC model was established by MNNG and treated with the corresponding drugs for 8 weeks. Then,RT-PCR and Western blot were used to observe the expression of Gli1/2/3 mRNA and gene level. Immunofluorescence was used to detect the protein expression of SUFU and Cyclin D1. Results Compared with the control group,Gli-1 mRNA was reduced in the model group( P < 0. 01),the protein expression of Gli-2 and Gli-3 were obviously up-regulated( P <0. 01); the expression of SUFU protein was strengthened and Cyclin D1 was weakened( P < 0. 01). Compared with the model group,Panax notoginseng could increase the expression of Gli-1 mRNA( P < 0. 05) and reduce the expression of Gli-2/3 and SUFU protein( P < 0. 05,P < 0. 01). The compatibility group could improve the expression of Gli-3 and SUFU( P < 0. 05,P < 0. 01),while Astragalus group could only reduce SUFU protein expression( P < 0. 01) and showed no obvious effects on other indexes. Conclusion Panax notoginseng for activating blood circulation can play a role in preventing PLGC by regulating the expression of key factors in hedgehog signaling pathway of stomach mucous of rats with precancerous lesions of gastric cancer( PLGC) so as to prevent precancerous lesions of gastric cancer.
摘要:Objective To study the effects of Shuangxin Biqiu San( SXBQS) on allergic rhinitis. Methods BN rats were immunized with a mixture of ovalbumin( OVA) and alum into their peritoneal cavity and OVA into their nasal cavity to establish an allergic reaction( AR),and the rats were divided into 6 groups: control,model,CTRZ,SXBQS-high,SXBQS-mid,and SXBQS-low group.Based on behaioral evaluation,the relations of time-effect and dosage-effect in SXBQS treated AR rats were preliminarily discussed and the effects of SXBQS were studied by observing the pathological changes of nasal mucous of rats under microscope and the contents of serum Ig E and histamine were detected. Results Nasal allergic signs could be remarkable alleviated 1 hour after SXBQS were administrated orally,and this effect could last at least for 12 hours. In SXBQS-high and SXBQS-mid groups,the infiltration of inflammatory cells into nasal mucous was inhibited and the mucosal edema was alleviated. In CTRZ group and SXBQS( high,mid and low) groups,the levels of serum Ig E were decreased compared with that of control group,the difference between the SXBQS high and mid groups with the model group had the statistical significance( P < 0. 05); the contents of histamine of SXBQS( high,mid and low)groups and CTRZ group were lower than that of the model group,and the difference was statistically significant between SXBQS high group and CTRZ with model group( P < 0. 05). Conclusion SXBQS can exerts anti-inflammatory edema by suppressing serum Ig E and histamine levels to treat AR.
关键词:Allergic rhinitis;Shuangxin Biqiu San;Chinese medicine;anti-allergy;time-effect and dose-effect relationship