摘要:Traditional Chinese Medicine( TCM) is rich in theoretical guidance and clinical practice in elderly frailty,but lack of rigorous assessment methods. Frailty assessment which focuses on single disease can’t fully reflect the complexity in frailty elderly. We should intensify the study on the diversification of elderly disease,and pay attention to the overall state of it. We combine the theory of"preventive treatment of disease"with geriatric assessment in order to guide TCM syndrome differentiation and treatment,and give a full play to the characteristics and advantages of TCM.
关键词:elderly;frailty;traditional Chinese medicine;assessment;intervention
摘要:Objective To explore the characteristics of TCM syndrome distribution in elderly frailty. Methods TCM differentiation and syndrome data of 61 cases of patients with elderly frailty were investigated by"Elderly Frailty TCM Syndromes Investigation Form".Results Qi deficiency and yin deficiency were two common deficiency types in elderly frailty patients. Qi depression and phlegm dampness were two common excess syndromes. Conclusion The appearance of elderly frailty is closely related to Qi deficiency of five zang organs and the decline of five zang organs is the core pathogenesis of elderly frailty.
摘要:Objective To develop Elderly Frailty Assessment Scale of Integrative Medicine to provide evaluation tool for evaluating TCM symptoms of frailty of elderly patients. Methods The primary item pool was formulated according to literature review,academic opinions of TCM doctors and peer review in meeting. The items were selected through expert consultations. Results The positive coefficient of the experts was 100%,and the expert authority coefficient was 0. 87. After two rounds of consultation,the Kendall’s W coordination coefficient of the expert opinions was 0. 484,and the value of χ2 were 822. 647( P < 0. 01). The Elderly Frailty Assessment Scale of Integrative Medicine consisted of 42 items,including 36 items of Qi deficiency,blood deficiency,Yin deficiency,Yang deficiency,deficiency syndrome leading to excess syndrome and 5 items of western medicine,and 1 item of medication. The scale content validity index( S-CVI) was 0. 90. The Cronbach ’s α coefficient of the scale was 0. 746. Conclusion The Elderly Frailty Assessment Scale of Integrative medicine based on the weakness index model with deficiency syndrome related symptoms of TCM as the core index is reliable and valid and can be used to evaluate elderly frailty.
摘要:Objective To establish frailty assessment method suitable to Chinese elderly with Elderly Frailty Assessment Scale of Integrative Medicine to evaluate the frail state of elderly inpatients. Methods The frail status of 108 elderly inpatients was evaluated by using geriatric assessment of Integrative Medicine( FI-TCM),comprehensive geriatric assessment( FI-CGA),and clinical frailty scale( CFS-09). Frailty index was calculated. The correlation between FI-TCM value,FI-CGA value and CFS-09 level of the inpatients was compared,as well as the frailty state of inpatients with different sex,age,hospitalization days and costs. Results The mean value of FI-TCM was 0. 28 ± 0. 15,FI-CGA was 0. 23 ± 0. 08,and the average level of CFS-09 was 3. 44 ± 1. 01. The difference of FI-TCM,FI-CGA and CFS-09 of male and female had no statistical significance( P > 0. 05). The FI-TCM value,FI-CGA value,and CFS level increased with age,hospitalization days,hospitalization costs; the differences had statistical significance( P < 0. 05). There was a positive correlation between FI-TCM value,FI-CGA value,and CFS-09 level( P < 0. 05),and a positive correlation between FI-TCM value and CFS-09 level. Conclusion Elderly Frailty Assessment Scale of Integrative Medicine is an effective model for the quantitative evaluation of the frail state of elderly inpatients,and can be used for the clinical practice of geriatric medicine.
关键词:integrative medicine;frail elderly;assessment;scale;frailty index;clinical practice
摘要:There are a lot of ancient TCM literatures about keeping fit during elderly and senile disease prevention. This paper makes a preliminary summary of the therapeutic principles and methods for elderly frailty through sorting out elderly frailty-related contents based on the basic theories of TCM recorded in ancient TCM literatures and provide references for the clinical practice.
摘要:Frailty seriously affects the life expectancy and quality of the elderly in our country. Multidisciplinary intervention model based on comprehensive assessment is the best strategy for health management of the frail elderly at present. Traditional Chinese medicine( TCM) has recognized the importance of diet,psychology and other factors on the health of the elderly for a long time. The multidisciplinary intervention model of TCM formulated based on the pathogenesis of the frail elderly has two major characteristics of TCM: holistic concept and treatment according to syndrome differentiation, and it also has certain advantages in effectiveness,practicality,an diversity.
关键词:elderly;frailty;multidisciplinary intervention;advantage;traditional Chinese medicine
摘要:Objective To investigate the cardiopulmonary endurance and ability of daily living( ADL) in aged women patients with sarcopenia and discuss the associations between them with TCM syndromes. Methods The enrolled aged women patients with sarcopenia were divided into two groups: syndrome of liver-kidney deficiency and syndrome of spleen-stomach deficiency. Cardiopulmonary endurance was measured by 6 Minutes Walk Test( 6 MWT) to evaluate the cardiopulmonary endurance and the ability of daily living was assessed by ADL Scale. The factors,including grip strength,walking speed,RASM,BMI,6 MWT,and ADL of two groups,were compared and analyzed in correlation,which were compared with the aged women without sarcopenia.Results 105 aged women,including 28 cases of aged women patients with sarcopenia( 16 cases in liver-kidney deficiency group,12 cases in spleen-stomach deficiency group) together with 77 cases of non-sarcopenia patients were recruited in the study. Compared with the non-sarcopenia group,the distance of 6 MWT were decreased significantly( P < 0. 05) and ADL scores were higher( P < 0. 05) in sarcopenia group. There was a positive correlation between 6 MWT and other factors including grip strength,walking speed,RASM,and BMI. A negative correlation was displayed between 6 MWT with ADL scores. Between group of liver-kidney deficiency and group of spleen-stomach deficiency,there were no statistical significances presented in their grip strength, walking speed, RASM, BMI,6 MWT,and ADL( P > 0. 05). Conclusion There was more or less a decline of cardiopulmonary endurance in elderly women patient with sarcopenia. A positive relationship was presented between cardiopulmonary endurance and the ability of daily living. The decline of cardiopulmonary endurance in elderly women sarcopenia may further reduce the quality of lives. There are no significant correlation between cardiopulmonary endurance and ability of daily living with TCM syndromes in elderly women sarcopenia.
关键词:geriatrics;sarcopenia;TCM syndromes;cardiopulmonary endurance;ability of daily Living
摘要:Objective To study the relationship between the onset of lumbar compression fractures with age and TCM syndromes in osteoporosis patients. Methods 800 patients diagnosed as osteoporosis aged between 55 and 85 were grouped into liver and kidney deficiency syndrome,spleen and kidney deficiency syndrome,and spleen and kidney deficiency syndrome; those primary osteroposis patients with height lose≥3 cm were given L1-L4 lumbar vertebral bone mineral density BMD value measurement( France MEDILINK dual light energy Xray absorptiometry,DEXA),combined with X-ray Genant semi-quantitative method to measure the lumbar L1 L4 anterior vertebral height and projection area and determine the incidence of lumbar compression fracture. Results Among 800 cases of elderly osteoporosis with height lose≥3 cm,the incidence of lumbar compression fracture was 81. 5%. In fracture patients,the fracture incidence was increased with ages as it was 10. 58% in 55-65 year-old group,27. 24% in 66-75 year-old group,and 61. 38% in 76-85 year-old group. Syndrome of spleen and kidney deficiency accompanied with blood stasis had the highest incidence of it of 69. 79%,much higher than that of syndrome of liver and kidney deficiency( 6. 55%) and syndrome of spleen and kidney deficiency( 19. 31%); and the differences were statistically significant( P <0. 01). Conclusion The incidence of lumbar compression fracture in patients with primary osteoporosis is increased with ages,syndrome of spleen and kidney deficiency with blood stasis has the highest fracture rate among three TCM syndromes.
摘要:Objective To observe the effects of Yangyin Qingfei Formula on the balance of Th17/Treg in peripheral blood of rats with radiation-induced pneumonia and explore its mechanism of prevention and treatment of this disease. Methods Fifty SD rats of half male and half female were randomly divided into blank group( C),model group( M),prednisolone group( J),TCM group( Z),TCM and prednisolone group( X). The whole chest of rats in four groups except the blank group was irradiated by a linear accelerator at a dose of16 Gy. From the first day after irradiation,each group was given the intervention. Four weeks after irradiation,10 rats in each group were sacrificed. HE and Masson staining were performed in the middle of right lung,and the whole blood samples were collected for flow cytometry. The pathological changes of lung tissue and the changes of Th17,Treg and Th17/Treg in 4 weeks after radiation were observed in each group. Results There was a significant difference in Th17 ratio between group M and group C at 4 weeks after radiotherapy( P = 0. 011 < 0. 05). There was no significant difference in Th17 between any two groups of group M,J,Z and X( P >0. 05). Compared with group C,the proportion of Treg in group M was slightly increased,but the difference wasn’t significant( P =0. 062 > 0. 05). The proportion of Treg in group J,Z and X was lower than that in group M( P < 0. 05). There was no significant difference in Treg between any two groups of group J,Z and X( P > 0. 05). The ratio of Th17/Treg in group M and C was increased with statistical difference( P = 0. 023 < 0. 05). There was no significant difference in Th17/Treg between any two groups of group M,J,Z and X( P > 0. 05). Conclusion Th17/Treg imbalance exists in the peripheral blood of rats with radiation-induced Pneumonia. Yangyin Qingfei Formula can effectively reduce inflammation and fibrosis in the local lung tissues of rats with radiationinduced pneumonia. The mechanism may be related to the inhibition of Treg.
摘要:Objective To develop a HPLC method for simultaneous determination of ferulic acid,Senkyunolide I,Senkyunolide H,Senkyunolide A,z-ligustilide,Butylidenephthalide and α-Cyperone in Ligusticum chuanxiong Hort.-Cyperus rotundus L.. Methods The HPLC system consisted of a Kromasil-C18 column( 4. 6 mm × 250 mm,5 μm),with the mobile phase of methanol solution( A)-water solution containing 0. 1% formic acid( B) for gradient elution. DAD detector was used and the detection wave lengths were 250 nm and286 nm. The flow rate was 1. 0 m L/min and the column temperature was 25 ℃. Results The liner relationships of seven effective components were favorable; the mean rate of recovery of each were 99. 7%,99. 6%,98. 9%,101. 2%,99. 4%,100. 3%,99. 0%,and RSD were 1. 7%,1. 5%,1. 3%,2. 3%,2. 2%,1. 6%,2. 1%; other methodological investigation results followed the requirements. Conclusion This method is simple,rapid and correct,and it can be used for simultaneous determination of seven effective components in Ligusticum chuanxiong Hort.-Cyperus rotundus L.,and meanwhile,provide scientific evidences for overall quality evaluation and control of it.