摘要:Objective The clinical data of 500 cases of inpatients with ulcerative colitis(UC) were retrospectively investigated and the characteristics of pathogenesis and diagnosis of ulcerative colitis analyzed. Methods The clinical information of the patients with ulcerative colitis were collected from January 2014 to June 2016,the basic information and the diagnosis situation were analyzed retrospectively. Results Among 500 patients,the male-female ratio was 1. 24∶1,the median age was 42 and the average course of the disease was 4. 5 years. There were 458 patients(91. 60%) in active and 42 patients(8. 40%) in remission period. Among the patients in active period,most of them were in mild or moderate(77. 07%) situation; and the chronic recurrence was the majority(90. 83%).The main sites of lesion were located at rectum in 95 cases(20. 74%),the left colon in 166 cases(36. 24%) and extensive colon in197 cases(43. 01%). Among the clinical features,the rate of diarrhea was the highest(74. 20%),the second was abdominal pain(69. 60%) and bloody mucopurulent stool(68. 20%). In the active period,the frequency of these symptoms was diarrhea(77. 07%),bloody mucopurulent stool(72. 71%) and abdominal pain(70. 09%). In addition,44 patients(8. 8%) had parenteral manifestations.Treatment drugs mainly focus on the combination of traditional Chinese and Western medicine. Among them,herbal medicine were taken orally in 483 cases(96. 60%),Chinese medicine enema were used in 423 cases(84. 60%). Western medicine treatment included oral amino salicylate drugs(91. 20%),external use of it(30. 40%),probiotics(93. 0%),glucocorticoids(17. 20%),immunosuppressive agents(2. 0%) and antibiotics(12. 45%). Most of the patients were discharged from internal medicine,and 2 cases were treated with operative treatment after ineffectiveness and unsatisfactory result. Conclusions In the past two years,hospitalized patients in our hospital mainly belong to chronic recurrent types in the mild and moderate condition. There are fewer parenteral manifestations and complications and the effect of combination of Chinese and western medicine is better.
摘要:Objective To evaluate the short term efficacy of Jianpi Wenshen Qinghua Formula(strengthening spleen,warming kidney,cleaning heat and dispelling dampness,and dispersing blood stasis) for ulcerative colitis(UC). Methods According to the multi-centered,randomized,and controlled clinical study design,80 patients with UC were divided into trial group of 37 case and control group of 35 cases.Mesalazine was taken as the basic treatment,the two groups were respectively treated by Jianpi Wenshen Qinghua Formula for enema and sulfasalazine suppository with anus for 4 weeks,and the remission rate and clinical curative effect of two groups were compared. Results At the end of treatment,the remission rate of the trial group was 56. 8% and that of the control group was 40. 0%,and the difference has no statistically significance(P > 0. 05). the remission rate of diarrhea symptom in trial group was 97. 2% while that was 78. 8% in the control group and the difference was statistically significant(P < 0. 05),and the effective rate of rest symptoms including purulent bloody stool,abdominal pain and distention between the two groups had no statistically significant difference(P > 0. 05). Conclusion Jianpi Wenshen Qinghua Formula has equivalent effect with Sulfasalopyridine suppository in the treatment of UC,but it can better improve diarrhea.
摘要:Objective Objective To explore the effect of Jianpi Liqi Formula(JPLQ) on TLR9,NF-κB and iNOS in the duodenum of functional dyspepsia(FD) rats. Methods Thirty six SD male rats were randomly divided into control group,FD model group and JPLQ group of twelve rats in each group. The FD model was established by tail clamping. Then the JPLQ group rats received JPLQ oral administration,while the control group and model group received normal saline. At the end of treatment,the duodenums of rats in each group were excised for the following experiments. The morphology of duodenum was measured by hematoxylin-eosin(HE) staining. The mRNA of TLR9 and NF-κB was tested by Quantitative real time polymerase chain reaction(q PCR),while the expression of iNOS was revealed by Western blot. Results The morphology of duodenum was normal in each group. The mRNA of TLR9,NF-κB and the expression of iNOS were remarkably increased in model group,and JPLQ treatment were significantly decreased in mRNA of TLR9,NF-κB and expression of iNOS. Conclusion JPLQ could block the TLR9-NF-κB/-iNOS signal pathway to ameliorate the duodenal inflammation,and this may be one of the mechanism underlying the JPLQ formula in treating FD.