摘要:Objective To study the current situation of blood glucose control of population with high risk of stroke combined with diabetes mellitus in some communities of Fengtai District,Beijing,and to analyze the characteristics of symptoms and syndromes of TCM among them. Methods In 2015,a total of 870 cases of high-risk population of cerebral apoplexy were screened from Beijing Fengtai Dahongmen Community Service Center and Tieying Community Service Center,including 266 patients with diabetes,their demographiccharacteristics,medical history,drug information and symptoms based on TCM four diagnostic information were recorded,and the fasting blood detection serum glucose( GLU),glycosylated hemoglobin( Hb A1 c),high-density lipoprotein( HDL-C) and low density lipoprotein( LDL-C),triglyceride( TG),total cholesterol( TCHO) level were tested. According to the fact whether Hb A1 c was less than6. 3%,they were classified into standing reaching group and not up to standard group,the two groups of blood glucose,blood lipids and other control conditions and the difference between the drug administration,and the symptoms of TCM syndrome characteristics in the patients with high risk of cerebral apoplexy combined with diabetes mellitus were analyzed. Results The incidence of diabetes in population with high risk of stroke was about 30. 6%,drug treatment was about 66. 9%,the coupon rate was about 45. 1%,among them,119 cases in Hb A1 c standard control group,the success rate was 44. 7%. Bad living habits such as smoking in not up to standard group was obviously higher than that in stand reaching group( P < 0. 05),stroke and TIA history were significantly higher than that in standard reaching group( P < 0. 05),total cholesterol levels in blood lipid test was higher than that in standard reaching group( P <0. 05). TCM symptoms in this population was mainly manifested as thirsty,insomnia,dizziness,which were more than half of the total number. The analysis of TCM syndromes: phlegm dampness syndromes accounted for 65. 4% of the population,qi deficiency syndrome51. 5%,interior fire syndrome 49. 2%,blood stasis syndrome 45. 9%,and Yin deficiency syndrome 35. 0%. Conclusion The incidence of diabetes in population with high risk of stroke is much more increased than in the general population,and the success rate of blood sugar control is lower,blood sugar control in not up to the standard group is worse,the incidences of stroke and TIA are more increased than that in successful blood sugar control group significantly; the use of hypoglycemic drugs in primary communities basically conforms to the standard. The syndromes of deficiency of spleen and kidney qi,interior obstruction of phlegm and dampness,and excessive fire due to yin deficiency are prominent in this group of people. The clinical treatment should base on differentiation of syndrome.
摘要:Objective To explore the effect and mechanism of Xuesaitong Capsule on angiogenesis in brain tissue of rats with single side carotid artery stenosis. Methods SD rats were randomly divided into 3 groups: sham group, Model group, Xuesaitong group. Model group and Xuesaitong group were fed with high fat diet for modeling carotid artery stenosis,and then immediately given Xuesaitong Capsule solution( 3. 15 mg/ml),and sham group and model group were given with 3 ml distilled water. All groups were treated once every 24 h for 42 days. Then the brain tissue were obtained by head cutting,HE staining was used to observe the pathological changes of brain tissue,Immunofluorescence to measure MVD,rt-PCR to investigate the mRNA expression of VEGF,and Western blot to detect the protein expression of VEGFR2. Results Compared with the Model group,the morphological structure of neurons of Xuesaitong group was clear,cytoplasmic of nerve cells was light staining,the cytoplasm of fewer neurons was concentrated,and the level of membrane shrinkage was also lower. Compared with Sham group and Model group,the MVD and the expression of VEGF mRNA and VEGFR2 in Xuesaitong group were all increased( P < 0. 05,P < 0. 05,P < 0. 01). Conclusion As a representative drug for activating blood and dissolving stasis,Xuesaitong Capsule can promote angiogenesis in brain tissue of rats with single side carotid artery stenosis,and the mechanism may be related to the activation of VEGF pathway.
关键词:carotid artery stenosis;Panax notoginseng saponins;Xuesaitong Capsule;angiogenesis;VEGF;activating blood and dissolving stasis;rat
摘要:Objective Objective To observe the pharmacodynamic action of Qibo Shengmai Granules on rats with atrial fibrillation. Methods The model with atrial fibrillation were established by caudal vein intravenous administration of calcium chloride and acetylcholine mixture( Ach-CaCl2). SD rats were randomly divided into normal control group,model group,positive control group,Qibo Shengmai Granules high/medium/low dose groups. After 4 weeks of administration,the mortality and duration of atrial fibrillation were calculated and the concentrations of serum c Tn T,CRP and Hcy tested. Results Compared with the model group,the duration of atrial fibrillation was Shortened in Qibo Shengmai Granules group and the mortality reduced,the levels of c Tn T,CRP and Hcy were decreased significantly in Qibo shengmai Granules high/medium dose groups and positive control group. Conclusion Qibo Shengmai Granules has remarkable effect on atrial fibrillation,and can reduce the duration and mortality,meanwhile,it can lower serum c Tn T,CRP,Hcy level,and atrial fibrillation can be treated by inhibiting the inflammation and oxidative stress,and improve myocardium tissue injury.