最新刊期
期 5 ， 2019
- 摘要：病机是决定病情变化的关键,针对慢性荨麻疹的中医核心病机,专家均强调风邪的重要意义;同时认为荨麻疹之所以慢性化是由于在风邪之外同时存在虚、瘀、毒等问题。寒热并存、虚实兼夹、阴阳并见导致其顽固难愈,风邪入络是其顽固化的重要原因。对此专家分别从祛外风、熄内风、填窍搜风、调理气血、治疗虚瘀毒等方面介绍了各自的经验,较全面地反映出中医药辨治慢性荨麻疹的思路和方法。关键词：慢性荨麻疹;病机;治法;风邪;燕京医学
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发布时间：2023-04-10 - 摘要：Objective Network pharmacology can show the characteristics of TCM compound prescriptions with multi-component, multi-target and overall synergistic action and provide a new strategy for the mechanism study of TCM compound prescriptions.Methods In this study, Banxia Xiexin Decoction, a classical prescription to treat chronic atrophic gastritis with definite clinical effect, was observed as a subject.First, the chemical constituents and corresponding drug targets of Banxia Xiexin Decoction were obtained by using the integrated pharmacological database of TCM（TCMIP）.Then,chronic atrophic gastritis disease targets were obtained through Human Phenotype Ontology database.The target interaction network was constructed based on protein interaction network（PPI）database, and a candidate target of Banxia Xiexin Decoction for chronic atrophic gastritis was obtained.Finally, GO function analysis and KEGG pathway enrichment analysis of candidate targets were conducted, and the possible biological pathways and processes of Banxia Xiexin Decoction in the treatment of chronic atrophic gastritis were concluded through literature studies.Results Firstly, 420 chemical constituents in the compound were obtained, 1228 predictive targets of drug action were predicted, and the target interaction network of Chinese herbal medicine was constructed and the corresponding GO and KEGG enrichment analysis Results were obtained.Secondly, five disease targets were combined with the predictive targets of Chinese herbal medicine, and the candidate targets of Banxia Xiexin Decoction for chronic atrophic gastritis were predicted.The molecular networks of Chinese herbal medicine-candidate targets contained in Banxia Xiexin Decoction and related molecular networks of Banxia Xiexin Decoction-candidate targets-chronic atrophic gastritis were constructed.The Results showed that Banxia Xiexin Decoction played an important role in regulating the expression of autoimmune factors, reducing inflammation, nerve growth factor, regulating gastrointestinal motility, protecting gastric mucosa, energy metabolism, improving immunity, regulating cholinergic nerve and inhibiting the proliferation of tumor cells.Conclusion The results of network pharmacological analysis combined with the literature of Banxia Xiexin Decoction on chronic atrophic gastritis suggest that the mechanism of action of Banxia Xiexin Decoction may be related to some biological pathways, such as interleukin, cyclooxygenase-2, MAPK cascade and ERK phosphorylation.关键词：Banxia Xiexin Decoction;chronic atrophic gastritis;integrated pharmacology;network pharmacology
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发布时间：2023-04-10 - 摘要：Objective To observe the immediate brain sustained effects of acupuncture at Fēngchí（GB 20）by using resting-state functional magnetic resonance imaging（rsfMRI）technique and explore the brain functional basis of acupuncture at GB20 for regulating visual cortex.Methods 11 healthy subjects randomly received acupuncture or Von Frey filaments（control）at left GB20.The stimulation time was 30 s and the frequency was 60 times/min.fMRI scan was conducted before and immediately after stimulation for 6 min.MATLAB-based DPABI4.3 software was used to analyze rsfMRI data,including fALFF,ReHo,DC for local brain activity changes,as well as the seed point bilateral posterior cingulate cortex（PCC）and the ventral medial prefrontal（VMPFC）for whole brain functional connectivity and observe the immediate brain sustained effect and whole brain functional connectivity after acupuncture at GB20.Results Compared with the tactile stimulation of Von Frey filaments,acupuncture at left GB20 could clearly modulate the right cuneus and right precuneus which involved to the visual function（voxel P value<0.01, cluster P value <0.05）.The FC between PCC and inferior parietal lobule（BA7, 39, 40）were enhanced, and the FC of the VMPFC and the right precuneus（BA7）were decreased（voxel P value<0.01, cluster P value<0.05）.Conclusion Acupuncture at GB20 could modulate the visual center and adjacent brain regions,as well as the default network,which may be an important brain function basis for the treatment of eye diseases.关键词：acupuncture;Von Frey filaments;Fēngchí（GB 20）;immediate sustained effect;visual cortex;resting-state functional magnetic resonance imaging（rsfMRI）
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发布时间：2023-04-10 - 摘要：Objective To explore the evaluation value of modified early warning score（MEWS）and acute physiology and chronic health evaluation score（APACHEⅡ）score on prognosis of sepsis patients with different syndrome types in ICU.Methods 187 sepsis patients in ICU of Guang′anmen Hospital of China Academy of Chinese Medical Sciences from January 2016 to December 2017 were scored in TCM syndrome types, MEWS and APACHE Ⅱ.The scores of two different types of syndromes were compared, as well as the mortality of different syndrome types, the two ROC curves drawn, the correlation and the AUC calculated,prognostic evaluation value of scores in two types evaluated;the correlation of scores of types.Results The mortality and two kinds of scores from low to high were the deficiency syndrome,excessive syndrome, syndrome of intermingled deficiency and excess, and the deficiency syndrome and the other two syndromes were statistically different（P<0.05）.The two scores of syndrome of intermingled deficiency and excess could effectively predict the death condition, and the correlation was significantly correlated with the Spearman test（P<0.01）;the mortality rates before and after the best truncation point of different syndrome type two scores were compared.The difference was statistically significant（P< 0.05）.Conclusion Two scores can evaluate the condition and evaluate the prognosis in the evidence and deficiency syndrome.关键词：Sepsis;MEWS Score;APACHE Ⅱ Score;TCM syndrome types;prognosis;ICU
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发布时间：2023-04-10 - 摘要：Objective To observe the effect of Jianpi Zhidong Decoction（JD）on the expressions of main neurotrophic factors in prefrontal cortex and striatum of Tourette syndrome（TS）rats.Methods 32 male SD rats were randomly divided into blank control group,TS model group,Tiapride group and JD group with 8 rats in each group.TS model rats were established by intraperitoneal injectioning IDPN（250 mg/kg/d）for consecutive 7 days.After modeling, blank control and TS model group were intragastricly administrated with physical saline, and the remaining two groups were administrated with Tiapride（21 mg/kg）and JD（16 mg/kg）respectively for 8 consecutive weeks.The rats were sacrificed after 24 hours of the last dose, and the specimens were taken and stored in liquid nitrogen.The contents of brain-derived neurotrophic factor（BDNF）, glial cell-line derived neurotrophic factor（GDNF）, vascular endothelial growth factor（VEGF）and transforming growth factor beta1（TGF-β1）were assayed by ELLSA.Results Compared with the blank control group, the contents of four factors in TS model group were decreased significantly（P<0.05）;compared with TS model group, the contents of four factors in Tiapride group and JD group were increased significantly（P<0.05）;compared with JD group, the four factors in Tiapride group were increased even more obviously（P<0.05）.The expressions of above four factors in prefrontal cortex and striatum were basically the same.Conclusion JD could elevate the expressions of neurotrophic factors in prefrontal cortex and striatum caused by IDPN.关键词：Jianpi Zhidong Decoction;Tourette syndrome;BDNF;GDNF;VEGF;TGF-β1;rats;neurotrophic factors
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发布时间：2023-04-10 - 摘要：Objective To compare the pharmacological effects of Shenma Yizhi Formula processed with 3 kinds of preparation techniques on learning and memory capability, brain histopathology, blood lipid indexes, oxidative stress indexes, inflammatory factors, cholinergic indexes in anisodamine-induced model rats.Methods 60 SD rats, 30 female and 30 male, were randomly divided into 6 groups with 10 rats in each group.3 Shenma Yizhi Formula groups with 3 different preparation techniques, including No.1 recipe group, No.2 recipe and No.3 recipe, were given the formula with 2.97 g·kg-1·d-1;the positive control group, donepezil hydrochloride tablet, with 0.45 mg·kg-1·d-1;the blank group and the model group, the equal amounts of pure water.After 4 weeks of delivery, the racemic anisodamine hydrochloride（2 mg/kg）was intraperitoneal injected separately to all the rats except for the blank group.The learning and memory ability of all rats was tested by Morris water maze.All rats were anesthetized by chloral hydrate.Serum indexes of lipids, superoxide dismutasee（SOD）, glutathione peroxidase（GSH-PX）, malondialdehyde（MDA）, interleukin-1β（IL-1β）, tumor necrosis factor-α（TNF-α）, nitric oxide（NO）, acetylcho1（Ach）and acetylcholinesterase（AchE）were tested, and the pathological morphology of hippocampal CA1 region observed.Results Compared with the model group, TC level of all Shenma Yizhi Formula groups were decreased（P<0.05）.SOD activity and NO level of rats in No.1 recipe group were significantly increased（P<0.05）.Compared with No.2 recipe group, the passing platform times of rats in No.3 recipe group were significantly increased（P<0.05）.Compared with No.2 recipe group and No.3 recipe group, the SOD activity of No.1 recipe group was significantly increased（P<0.05）.Compared with No.3 recipe group, the level of TNF-α was decreased in No.1 recipe group and No.2 recipe group, and the level of NO was increased（P<0.05）.Conclusion The pharmacological effects of Shenma Yizhi Formula prepared with 3 kinds of techniques are different, and the pharmacological effect indexes of No.1 recipe were better than those of No.2 recipe and No.3 recipe.关键词：vascular dementia;Shenma Yizhi Formula;oxidative stress;inflammatory factor;behavioral testing;rats
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发布时间：2023-04-10 - 摘要：痛风是代谢综合征中最常见的疾病,严重者呈关节畸形和（或）肾脏衰竭,治疗棘手。中西医结合治疗能够减少西药用量,减少不良反应,并能够明显改善疼痛等不适症状。倪青教授认为本病常由多种原因诱发湿热内生,加之脾肾不足,导致湿浊瘀阻经脉关节为病,湿热、痰浊、瘀血痹阻经络为其关键病理环节。治疗上多采用微观辨证,用药上结合现代药理学研究,将药物直接作用于靶点,在间歇发作期投以二至丸合四妙丸以滋肾泄浊,不仅可改善患者临床症状,而且能使相关指标转阴;同时重视预防调护,已病防变,以提高临床疗效。关键词：倪青;痛风;高尿酸血症;中医药;滋肾泄浊法;名中医经验
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发布时间：2023-04-10 - 摘要：口腔扁平苔藓是一种常见口腔黏膜慢性炎症,目前西医治疗复发率高、根治率低,且不良反应明显。李平教授认为糜烂型口腔扁平苔藓可参照中医"口疮"进行辨证论治。其病机虚实夹杂,但脾胃受损、中气不足、湿热上蒸是其核心病机,治疗上李教授从调节中焦脾胃入手,法以补土伏火,以甘草泻心汤加减治疗,疗效颇佳。关键词：李平;扁平苔藓;口腔;黏膜病;甘草泻心汤;经方;名中医经验
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发布时间：2023-04-10 - 摘要：赵瑞华教授临床擅从脾胃论治妇科疑难杂病,其不仅重视脾胃气血生化源头作用,同时注重脾胃运化功能;主张补益脾气,认为脾胃充,则血海足;正气盛,则邪气祛;通过健运脾胃中州,调畅升降气机,防治痰湿等代谢产物积聚。基于脾胃的生理功能,总结赵教授治疗月经过少、子宫内膜异位症、多囊卵巢综合征的临床经验,启发后学。关键词：赵瑞华;妇科疑难病;从脾胃论治;月经过少;子宫内膜异位症;多囊卵巢综合征;名中医经验
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发布时间：2023-04-10 - 摘要：杨顶权教授采用中西医结合、辨病辨证结合的方法认识雄激素性秃发,主张早期、长期、规范、联合和个体化的诊疗原则。从中医角度来看,本病主要与湿热内蕴、肝郁脾虚、肝肾亏虚或气滞血瘀等相关,湿热上蒸、气血不足、精血亏虚或血行不畅、肌肤失荣、毛窍失养而毛发脱落。杨教授主张从肝、脾、肾论治,病初强调清热利湿、凉血生发;中期主张疏肝健脾、养血生发;后期侧重补益肝肾、填精生发或行气化瘀、活血生发。中医辨证论治可协调脏腑,调达气血,使肾气盛、脾气足、肝气疏、气血充、湿热除、瘀滞通,故头皮荣、发得养而发生。从西医角度认识本病发病的病因复杂性,采用规范化分级诊疗和精准治疗。杨教授临证重视中西医诊治规律,病证结合,内外结合,防护兼顾,可达到较为理想的防治效果。关键词：杨顶权;雄激素性秃发;中西医结合疗法
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发布时间：2023-04-10 - 摘要：目前盆腔炎性疾病后遗症的治疗多采用中成药或抗生素,但部分患者治疗效果欠佳。根据仝小林教授提出的"脏腑风湿"理论,认为盆腔炎性疾病后遗症属于"脏腑风湿病"范畴,以脏腑风湿理论为指导进行治疗可以取得较好的临床疗效。关键词：盆腔炎性疾病后遗症;脏腑风湿;中医药疗法;仝小林
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发布时间：2023-04-10 - 摘要：月经后期是月经失调中的常见类型,常合并月经量少,一般采用补肾养血、活血通经法等治疗,但对于有受寒史的一类患者却常难以奏效。根据仝小林教授的"脏腑风湿"理论,认为此类月经后期属于"脏腑风湿病"范畴,以脏腑风湿理论为指导进行治疗,取得了较好的临床疗效。关键词：月经后期;脏腑风湿;中医药疗法;仝小林
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发布时间：2023-04-10 - 摘要："诸气膹郁,皆属于肺"出自《黄帝内经》,属于病机十九条之一。病机十九条被认为是临床分析疾病病机的重要依据,对指导临床治疗具有重要价值。目前"诸气膹郁,皆属于肺"的意思理解为呼吸困难、胸闷憋气的疾病与肺相关。笔者认为"肺"与"诸气"存在动态平衡关系。"诸气"包括六气或人身之气,其变化可因肺功能异常而诱发,也可作为致病因素损伤肺叶及影响肺的正常功能,因而对于该病机的应用不应局限于呼吸困难等。在历代医家认识的基础上,从"诸气"失衡致肺病、"肺"失调节牵"诸气"变动、"气"的循环失衡致内伤外感之变及临床应用等方面,深入探讨和发掘"诸气膹郁,皆属于肺"病机之用。关键词：病机十九条;肺;诸气;动态平衡
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发布时间：2023-04-10 - 摘要：现代外科中绝大多数疾病在中医学中均无相对应的疾病或名称,其中医病机、辨证论治等均无典籍可循。胃癌患者术后的中医症状并非均以虚证为主,患者术前的营养状态是影响术后临床表现及中医证候分型的主要因素之一。中医学认为,胃属六腑之一,"胃主降浊""以通为用""实而不能满",实际上是指胃的正常蠕动及排空功能;"脾主运化"指的是营养物质的吸收功能。胃癌手术行胃部分切除或全部切除后,胃的"降浊"功能和"脾主运化"功能会直接受到影响,这也是影响胃癌患者术后证候变化的另外两个主要因素。因此,要重视胃癌术后患者脾胃脏器的病理生理变化,中医辨证论治才能有的放矢。关键词：胃癌;手术;辨证论治;胃主降浊;益气养阴;脾主运化;健脾通腑;病理生理学
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发布时间：2023-04-10 - 摘要：掌跖脓疱病,中医称为"瘑疮",历代医家对本病的认识均着眼于阳证、热证、实证。基于掌跖脓疱病的病因病机,掌跖脓疱病患者常同时合并"痹症"的表现,从而提出从"寒湿"治疗掌跖脓疱病的新思路,以散寒祛湿、表里双解的代表方剂五积散化裁治疗,效果较好。关键词：掌跖脓疱病;瘑疮;寒湿;五积散
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发布时间：2023-04-10 - 摘要：气郁的内涵即气机郁抑不畅,气郁久而不解,则继发火郁、血郁、湿郁、痰郁、食郁以及五脏本气郁结等病证,气郁与气滞相同,症状相似但一轻一重,可以相互转变。体质因素、外感风邪和寒邪、情志失调、劳倦过度均可导致气郁的产生。气郁可导致血瘀和生痰,其中生痰包括气郁直接生痰和气郁化火间接炼液为痰,同时痰和瘀血还可加重气郁临床表现,可见胸满胁痛、心悸、痞满、腹胀、情志异常、不寐郁劳、梅核气、阳痿等病证。气郁是六郁之始,及时干预可以做到"未病先防,既病防变"。强调气郁作为始动因素的重要性,希望为治疗追本溯源,提供新的思路。关键词：气郁;病因病机;临床表现
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发布时间：2023-04-10 - 摘要：基于中医经典理论及现代医学对胃食管反流病发病机制的认识,从"脾虚"与"胃强"角度探究胃食管反流病的病因病机,并就胃食管反流病的不同疾病类型的病机特点进行探讨,在此基础上针对不同类型的病机确立相应治则治法方药,从而指导临床胃食管反流病的治疗。关键词：胃食管反流病;脾虚;胃强;发病机制
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发布时间：2023-04-10 - 摘要：目的评价脊柱推拿手法降低初发2型糖尿病（T2DM）患者血糖指数及相关症状的可行性和作用。方法将首次诊断为T2DM同时具有背部症状的患者103例,采用随机数字表法分为治疗组51例和对照组52例。治疗组给予脊柱推拿手法+药物治疗,对照组给予单纯药物治疗,药物均为盐酸二甲双胍缓释片,基础剂量为0.5 g,每日1次,根据患者病情记录实际用药量,对比2组主要血糖指标、背部症状、中医证候积分的疗效差异。结果治疗组治疗后空腹血糖（FPG）、餐后2 h血糖（2 hPG）、糖化血红蛋白（HbA1c）均较治疗前显著降低,差异有统计学意义（P<0.05）,在改善患者2 hPG方面明显优于对照组（P<0.05）,2组FPG、HbA1c差异无统计学意义（P>0.05）;治疗组用药量明显少于对照组（P<0.01）;治疗组在改善患者中医证候积分、疼痛积分方面明显优于对照组（P<0.01）。结论脊柱推拿手法能有效降低初发T2DM伴有背部症状患者的2 hPG水平,显著改善患者的背部疼痛、中医症状,在稳定疗效的同时可以减少患者的口服药物量,从而提高患者的生存质量。关键词：脊柱推拿手法;初发2型糖尿病;血糖指数;背部症状;中医证候;症状
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发布时间：2023-04-10 - 摘要：目的评价颈椎康复丸（JKW）治疗肝肾亏虚型强直性脊柱炎（AS）附着点炎的疗效和安全性。方法将80例AS患者随机分为JKW组和双氯芬酸钠组各40例,分别给予JKW、双氯芬酸钠,疗程12周。以治疗12周时达到国际强直性脊柱炎评估组（ASAS）制定的ASAS-20标准的患者比例为主要疗效指标,临床观察Bath AS病情活动指数（BASDAI）、Bath AS功能指数（BASFI）、Bath AS测量指数（BASMI）、附着点炎临床评分（MASES评分）以及双下肢附着点评分（超声GUESS评分）、非甾体抗炎药（NSAIDs）摄入量等效积分。结果 JKW组和双氯芬酸钠组治疗4周及8周时,BASDAI、BASFI、BASMI评分均较治疗前改善,12周时BASDAI、BASFI均较治疗前下降,差异有统计学意义（P<0.01,P<0.05）。从4周开始,2组附着点压痛数和下肢附着点超声评分均有下降,12周时MASES评分及GUESS评分与治疗前比较差异均有统计学意义（P<0.05）。2组之间比较差异无统计学意义（P>0.05）。治疗12周时,JKW组NSAIDs摄入量等效积分为（45.26±18.85）,与双氯芬酸钠组（65.85±7.14）相比,差异有统计学意义（P<0.01）。治疗12周时,主要疗效指标经意向性分析,JKW组和双氯芬酸钠组ASAS-20分别为50.00%（20/40）、52.5%（21/40）,2组间差异无统计学意义（P>0.05）。2组均未发生严重不良事件。结论 JKW治疗AS有一定疗效,并可改善附着点炎,短期安全性较好。关键词：强直性脊柱炎;肝肾亏虚;附着点炎;颈椎康复丸;超声;中医药疗法;中医药
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发布时间：2023-04-10 - 摘要：目的观察半夏泻心汤治疗幽门螺杆菌（Hp）相关性胃炎的临床疗效。方法将Hp相关性胃炎患者120例按就诊顺序分为对照组、治疗组2组,每组60例,除去脱落病例,对照组完成58例,治疗组完成57例。对照组给予经验性四联疗法治疗,治疗组给予半夏泻心汤,用药14天后判定疗效。2组均在停药后1个月复查Hp。结果治疗组中医证候改善总有效率91.23%,优于对照组的53.45%（P<0.05）;治疗后治疗组患者胃胀、胃痛、恶心呕吐、纳呆、大便异常、眠差中医症状积分与对照组比较差异有统计学意义（P<0.05）;治疗组Hp根除率68.42%,对照组82.76%,2组比较差异无统计学意义（P>0.05）。结论半夏泻心汤对Hp有一定的抑杀作用,在改善患者胃胀、胃痛、恶心呕吐、纳呆、大便异常、眠差等临床症状方面明显优于四联疗法,且不良反应少于四联疗法。关键词：半夏泻心汤;幽门螺杆菌;胃炎;四联疗法
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发布时间：2023-04-10 - 摘要：目的评价多次、短时中药熏蒸法对蒸发过强型干眼的疗效。方法选择2016年8月—2017年6月蒸发过强型干眼患者60例,随机分为对照组、治疗组2组,对照组应用单次、长时中药熏蒸法,治疗组应用多次、短时中药熏蒸法,10天为1个疗程,连续治疗2个疗程。比较2组治疗后泪膜破裂时间（BUT）、泪河高度改善效果。结果治疗组治疗后第10、20、30、60、90天BUT、泪河高度均高于对照组,差异有统计学意义（P<0.05）。结论多次、短时中药熏蒸法可以延长蒸发过强型干眼患者的BUT,提高泪河高度,缓解患者的干眼不适症状。关键词：干眼,蒸发过强型;中药熏蒸;干预
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发布时间：2023-04-10 - 摘要：目的评价牛黄降压中成药治疗原发性高血压的疗效和安全性。方法通过检索Cochrane Library、Pubmed、EMbase、中国生物医学文献数据库（CBM）、CNKI、VIP、万方等数据库,全面搜集有关牛黄降压中成药治疗原发性高血压的随机对照试验,并对文献进行筛选、资料提取和质量评价,质量评价参照Cochrane handbook 5.1.0标准,数据分析采用Revman 5.3。结果有6篇文献纳入评价,收缩压（SBP）数据分析结果:MD=4.56,95%CI为[-6.55,15.67],P=0.42,以固定效应模型进行敏感性分析,MD=-0.79,95%CI为[-2.75,1.16],P=0.43,提示结果稳定。舒张压（DBP）分析结果:MD=-0.19,95%CI为[-5.55,5.18],P=0.95,以固定效应模型进行敏感性分析,MD=-3.38,95%CI为[-4.56,-2.19],P<0.00001,提示结果不稳定。4个研究采用降压有效率指标,合并效应量RR值为1.03,95%CI为[0.74,1.44],P=0.84,以固定效应模型进行敏感性分析,RR值为1.17,95%CI为[1.07,1.28],P=0.0009,提示结果不稳定。4个研究报告了不良反应,不良反应发生率分析结果:RR值为0.12,95%CI为[0.01,1.22],P=0.07,以固定效应模型进行敏感性分析,RR值为0.12,95%CI为[0.08,0.20],P<0.00001,提示结果不稳定。SBP或DBP变化相关漏斗图提示研究可能存在一定的发表偏倚。结论牛黄降压丸（片、胶囊）可能具有与一线降压西药相当的降压效果,但因为研究的异质性较高,尚不能得出肯定的结论。关键词：高血压;牛黄降压;中成药;系统评价;Meta分析
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发布时间：2023-04-10 - 摘要：<正>《北京中医药》杂志是由北京市中医管理局主管,北京中医药学会、北京中西医结合学会、北京市中药研究所共同主办的国内外公开发行的中医药科技期刊。杂志为"中国科技论文统计源期刊"（中国科技核心期刊）、全国中医药优秀期刊、中国期刊全文数据库全文收录期刊、中国学术期刊综合评价数据库统计源期刊。本刊设有燕京医学论坛、指南与共识、临床研究、实验研究、学验传承、学术探讨、临证纵横、方药经纬、医案医话、文献综述等栏目。欢迎踊跃投稿和订阅。本刊为月刊,大
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发布时间：2023-04-10 - 摘要：目的介绍外用制剂临床专家共识的研制方法。方法参考中华中医药学会《中成药临床应用专家共识的制订流程》,通过组建制订专家组、临床问卷调研、文献检索及综合分析、共识形成推荐意见等过程完成临床专家共识的制订。结果顺利制订了奇正消痛贴膏临床专家共识,已通过了中华中医药学会的审核并发布。结论外用制剂临床专家共识可参考中成药临床专家共识的制订方法进行研制。关键词：外用制剂;临床专家共识;研制方法;奇正消痛贴膏
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发布时间：2023-04-10 - 摘要：目的评价中药制剂治疗糖尿病足溃疡随机对照试验RCTs报告质量,并调查所纳入研究相关期刊的CONSORT声明应用现状。方法系统检索CNKI、中国科技期刊数据库（VIP）、万方、SinoMed、PubMed、Cochrane图书馆、Embase等数据库,查找中药制剂治疗糖尿病足溃疡RCTs。2名评价者独立进行文献筛选和文献管理,依据CONSORT声明评价RCTs的报告质量,并统计结局指标报告率。通过电话访谈原作者获取报告缺失的信息。逐一查看所纳入文献的期刊投稿要求是否包含CONSORT声明报告。结果最终纳入49个RCTs,其中4项研究以英文发表,其余45项研究以中文发表。根据CONSORT条目,随机序列产生方法、分配方案隐藏、盲法、样本量计算、脱落或剔除、结局指标、不良反应及研究方案注册报告率分别为44.9%、6.1%、4.1%、2.0%、8.2%、30.6%、18.4%、4.1%。结局指标溃疡100%愈合、溃疡愈合超过50%、治疗后溃疡面积、溃疡完全愈合时间、不良事件报告率依次为83.7%、34.7%、28.6%、18.4%、18.4%。仅有1项（2.0%）试验与原作者联系成功并接受笔者访谈,其余访谈不能良好开展的主要原因是文章发表的年代久远以及作者提供给杂志社的联系信息不全。结论中药制剂治疗糖尿病足溃疡RCTs的报告质量较低,CONSORT声明在本研究领域的中文期刊中未获得广泛采纳,电话访谈成功率较低且难以获得试验报告中的缺失信息,提示中文期刊未来应当重视依据CONSORT声明规范临床试验报告。关键词：糖尿病足溃疡;中药;CONSORT;电话访谈;报告质量;随机对照试验
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发布时间：2023-04-10 - 摘要："假苏"之名始见于《神农本草经》,"荆芥"作为"假苏"之别名出自《吴普本草》,而"假苏"与"荆芥"等究竟是否异名同物,后世医家观点不一。借助训诂学的理论及方法分析认为,"假苏""荆芥"等名称是对同一种植物的描述,这种异名同实的现象在汉语中亦十分普遍。这种现象是汉语词汇丰富、精细、表述多样的表现。进一步通过考证文献和整理古汉语植物类中药的命名特点,认为"假苏"实际上就是以"苏"类比进行命名的例子,而荆芥和薑芥的命名亦是如此。同时根据命名中的具象性特点及命名规律,推测这可能是荆芥能取代假苏而作为正名沿用至今的原因。借助训诂学的方法研究植物类中药的命名规律,不仅有助于研究植物类中药的历史沿革,还能为拓展植物类中药的临床应用提供更广泛的理论依据。关键词：假苏;荆芥;植物类中药;命名规律;训诂学;名物研究
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发布时间：2023-04-10 - 摘要：目的对芙蓉喷膜剂制剂工艺和初步药效学进行探讨。方法以小檗碱、黄芩苷为考察指标,设计正交实验,得出处方最佳提取工艺;通过单因素考察设计实验,确定芙蓉喷膜剂的制剂成型工艺;观察芙蓉喷膜剂对大鼠角叉菜所致足跖肿胀的影响,初步评价芙蓉喷膜剂的药效学。结果黄连、黄柏加8倍量70%乙醇提取2次,每次提取时间为1 h;黄芩等药加8倍量70%乙醇提取2次,每次提取时间为2 h。中药浓缩药液加入到聚乙烯醇（规格1 750±50）、甘油、氮酮中,恒温加热使成膜材料溶解,取上清液,加入冰片、羟苯乙酯即得到芙蓉喷膜剂成品。芙蓉喷膜剂对角叉菜所致大鼠足跖肿胀有抑制作用,且与氢化可的松软膏、芙蓉膏比较差异无统计学意义（P>0.05）。结论芙蓉喷膜剂的提取和制剂工艺合理可行,抗炎作用明确。关键词：芙蓉喷膜剂;提取工艺;制剂工艺;药效学
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发布时间：2023-04-10
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