摘要:Objective To investigate the effect of modified Huanglian Ejiao(MHLEJ) Decoction on the treatment of generalized anxiety disorder(GAD)in community. Methods Eighty-four patients with heart-kidney disharmony type of GAD,who visited community health center under the Beijing University of Chinese Medicine and other nearby community health centers from January 2015 to May 2016,were selected and divided into experimental and control groups by using random number table method with forty-two cases each and respectively treated with MHLEJ Decoction and Lorazepam for two weeks. The Hamilton Anxiety Scale(HAMA) and TCM syndrome score were used to compare the results and evaluate the clinical efficacy,and the HAMA rate of score-reducing and efficacy index were used to assess the clinical efficacy before and after treatment of two groups. The follow-up at the third mouth was given after the treatment. Results The differences of scores of HAMA and TCM syndrome between the two groups had no statistical significance after one week of treatment(P>0.05); the difference of HAMA scores between the two groups had statistical significance after two weeks of treatment(P<0.05)and the efficacy of TCM syndrome was remarkably different(P<0.01),and the side effect score was remarkably different(P<0.01).The follow-up results showed that the long-term recurrence rate of the experimental group was lower than that of the control group. Conclusion The MHLEJ Decoction can improve anxiety and TCM symptoms of heart-kidney disharmony type of GAD in community with safety.
摘要:Objective To observe the clinical effect of Yishen Jiangu Pill in the treatment of knee osteoarthritis of liver and kidney deficiency type. Methods 120 cases of knee osteoarthritis with liver and kidney deficiency were randomly divided into observation group and control group with 60 cases in each group. The observation group was treated with Yishen Jiangu Pill,and the control group was given glucosamine sulfate. After 12 weeks,the clinical efficacy and safety of two groups were compared. Results The visual analogue scale(VAS) at activity,vas at rest,WOMAC,as well as pain,stiffness,joint function,Lysholm score of knee function and TCM symptom score of the observation group after the treatment were all better than that before the treatment,compared with the control group,the difference was statistically significant(P<0.01 or P<0.05). According to WOMAC score which was taken as the evaluation standard of efficacy,the total effective rate was 89.93% in the observation group and 75.00% in the control group,with statistical significance between the two groups(P<0.05). Conclusion Yishen Jiangu Pill can reduce pain and stiffness of knee osteoarthritis patients with liver and kidney deficiency and improve the joint function with safety.
关键词:Yishen Jiangu Pill;deficiency of liver and kidney;knee osteoarthritis
摘要:<正>经皮给药系统(transdermal drug delivery system,TDDS)是指经皮肤给药,使药物透过皮肤由毛细血管吸收进入血液循环,达到有效血液浓度并转移至病变部位,起到局部或全身作用的制剂[1]。当前常见的经皮给药剂型有凝胶剂、巴布膏剂、涂膜剂和贴剂[2]。中医贴敷疗法与经皮给药系统有相类似之处,是以中医基本理论为指导,应用中草药制剂,施于皮肤、孔窍、腧穴及病变局部等部位的治病方法,属于中医外治法的一种。由于经皮肤给药,