最新刊期
期 4 ， 2020
- 摘要：2020年12月,武汉市爆发新型冠状病毒肺炎（COVID-19）疫情,迅速波及全国。医疗机构疫情防控是管理重中之重,以首都医科大学附属北京中医医院疫情防控管理实践为例,从组织机构建设、制度建设、物理防控、人员管理、培训管理、后勤管理、医疗队组建及应急物资管理、绩效管理、医疗质量安全管理、疫情防控中的中医特色发挥等方面应用中医医疗机构疫情防控管理措施,可加强医疗机构疫情防控。关键词：新型冠状病毒肺炎;医院管理;疫情防控;策略
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发布时间：2023-04-11 - 摘要：新型冠状病毒肺炎（COVID-19,简称"新冠肺炎"）,被国家卫生健康委员会纳入传染病防治法乙类传染病,实行甲类管理。新冠肺炎疫情发生以来,中医药积极参与,主动作为,在抗疫工作中取得了良好的临床效果。通过梳理总结治疗新冠肺炎临床常用中药注射剂、中药口服剂用药护理要点,如药物检查,给药时间,饮食调护,不良反应预防、监测及处理,用药注意事项等,旨在为广大护理人员提供中药用药护理参考,提高中药临床应用的安全性与有效性,共同促进中医药在新冠肺炎治疗中的合理应用。关键词：新型冠状病毒肺炎;中医药;用药护理
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发布时间：2023-04-11 - 摘要：在全国抗击新型冠状病毒肺炎疫情期间,北京中医药大学东方医院作为国家援鄂抗疫中医医疗队奔赴湖北中西医结合医院紧急驰援。笔者作为其中一员,在隔离病区工作中发现,当传染性公共卫生事件突发时,护士需要承担更多的工作,故将护理职能集中在防护、感染控制、患者管理、中医护理四方面及相关风险点加以总结。在特定环境下,只有充分明确自己的工作职能及风险点才能安全、高效、准确地完成自己的工作任务。关键词：新型冠状病毒肺炎;中医护理;职能;风险
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发布时间：2023-04-11 - 摘要：基于中西医协同诊疗,在北京医院老年多学科诊疗深厚积淀基础上,结合目前本院援鄂医疗队接管的武汉华中科技大学同济医院中法新城院区B区11东病房收治的老年新型冠状病毒肺炎患者的临床实践,从老年人新型冠状病毒肺炎的发病特征、中西医协同诊疗等方面进行初步探析,尤其从中西医优势互补、诊疗互通、有主有辅、中医特色发挥等方面进行进一步思考和观点阐释。关键词：新型冠状病毒肺炎;中西医协同诊疗;老年;多学科
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发布时间：2023-04-11 - 摘要：Objective To observe the clinical efficacy of modified Shenqi Dihuang Decoction in treating early stage of diabetic kidney disease（DKD）.Methods 66 cases of early DKD patients with deficiency of Qi and Yin and obstruction of collaterals were retrospectively enrolled of 33 cases in each group.The control group was given the basic treatment for diabetic nephropathy.The treatment group was given Shenqi Dihuang Decoction Granules on the basis of the control group.The clinical efficacy,TCM syndrome score,fasting blood sugar（FPG）,2 h postprandial blood glucose（2 hPBG）,glycosylated hemoglobin（HbA1 c）,blood pressure,urea nitrogen（BUN）,serum creatinine（Scr）,urinary albumin creatinine ratio（UACR）,homocysteine（HCY）and superoxide dismutase（SOD）changes of the two groups were observed after 12 weeks of treatment.Results After treatment,the clinical effect,blood glucose,blood lipid,blood pressure,and SOD in the treatment group was significantly improved compared with that before treatment,TCM syndrome score,2 hPBG,HbA1 c and UACR of the treatment groups were better than those of the control group with the difference statistically significant.Conclusion The combined treatment of modified Shenqi Dihuang Decoction with basic treatment can improve the clinical symptoms of early DKD patients with deficiency of Qi and Yin and obstruction of collaterals and control the progress of kidney disease,and it can provide new ideas for the treatment of early DKD with traditional Chinese medicine.关键词：Modified Shenqi Dihuang Decoction;Diabetic kidney disease;urine protein
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发布时间：2023-04-11 - 摘要：Objective To study on the mechanism of Xinnaoning Capsule in treating coronary atherosclerotic heart disease（CHD）based on network pharmacology.Methods Searching the targets of Xinnaoning Capsule for the treatment of CHD through the Chinese Medicine Database（TCMSP）and disease database,and these targets were enriched and analyzed in the DAVID database,the mechanism of action of Xinnaoning Capsule in the treatment of coronary CHD was analyzed using Cytoscape for drawing,the binding degree between targets and small molecule by molecular docking technology was verified.Results There were 95 action targets in the treatment of CHD by Xinnaoning Capsule.In the enrichment analysis,the reaction and inflammatory response of the biological process cells were most significant.The TNF signaling pathway was most prominent in the KEGG analysis.Tumor necrosis factor-alpha had an active binding activity with kaempferol.Conclusion Based on network pharmacology,it is predicted the Xinnaoning Capsule for the treatment of coronary heart disease is characterized by multi-components,multi-targets and multi-pathways,so it can provide a theoretical basis for the experimental study of Xinnaoning Capsule.关键词：Xinnaoning Capsule;coronary atherosclerotic heart disease;network pharmacology
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发布时间：2023-04-11 - 摘要：Objective To observe the curative effect of opioid-induced-constipation（OIC）with the method of tonifying Qi and nourishing Yin,and explore its possible mechanism.Methods 60 cases of patients with stage Ⅲ a and Ⅲbliver cancer treated from January to December 2018 who were all complicated with OIC were divided into observation group and control group of 30 cases in each group with stratified random sampling method.Both groups were given transcatheter arterial chemoembolization and oxycodone for pain relief as the basic treatment.The control group was also given lactulose oral liquid 10 mL/time and 3 times a day.While the observation group was also treated with Chinese herbal medicines for tonifying Qi and Yin.The course of treatment were both 4 weeks.The improvement of clinical symptoms,BFI,pelvic floor electromyography and the expression of serum β-arrestin2 and related AQPs were observed and the the adverse reactions during the treatment were collected.Results 1.The effective rate of the observation group and the control group were 73. 3% 和 46. 7% respectively,BFI was lowered in both groups,the observation group improved more significantly（all P<0. 05）; 2. After treatment,the maximum amplitude of rapid contraction in the observation group was increased,while the coefficient of variation of sustained contraction and the coefficient of variation of durable contraction decreased（all P<0.05）. There was no significant difference between the amplitude of the front baseline and the amplitude of the rear baseline（P>0.05）. 3. Compared with the blank group before treatment,β-arrestin2 and serum AQP3,AQP4 and AQP8 in the patient ’s serum were significantly improved,and AQP2 reduced in the observation group（P<0. 05）. After treatment,the expressions of serumβ-arrestin2,AQP3,AQP4 and AQP8 of the observation group decreased（P<0. 05）,and the expression of AQP2 increased（P<0. 05）,while there was no significant difference in the indexes in the control group（P>0. 05）. Conclusion The method of tonifying Qi and nourishing Yin can improve the clinical symptoms, BFI, pelvic floor muscle strength and motor coordination, and regulate the expression of serum β-arrestin2 and related AQPs by tonifying Qi and Yin for patients with OIC.关键词：constipation;tonifying Qi and nourishing Yin;opioid drugs
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发布时间：2023-04-11 - 摘要：Objective To observe the effect of modified Changpu Yujin Decoction on the blood ammonia level and expression of GFAP and AQP4 in the brain of rats with acute-on-chronic liver failure.Methods The Wistar rats were randomly divided into normal group,model group and modified Changpu Yujin Decoction group（administered group）.The model of acute-on-chronic liver failure was established by acute attack of human serum albumin combined with D-GalN/LPS.After the modeling was completed,the rats in administered group were treated with modified Changpu Yujin Decoction for 10 days.The rats in the model group and control group were given 0.9% normal saline for 10 days.ALT,AST and TBIL of each group were tested;the arterial blood ammonia level was detected by glutamate dehydrogenase rate method.The pathological changes of liver tissues were observed by HE staining.The ultrastructural changes of brain tissues were observed by transmission electron microscopy.The expression of GFAP and AQP4 in cortex of rats were detected by immunofluorescence staining.Results ALT,AST and TBIL,as well as the arterial blood ammonia level of modified Changpu Yujin Decoction group were reduced（P<0.05）,the astrocyte edema improved,the expression of AQP4 decreased（P<0.05）and the expression of GFAP increased（P <0.05）.Conclusion The modified Changpu Yujin Decoction could improve liver damage and reduce the blood ammonia level,regulate the expression of AQP4 and improve the astrocyte edema in rats with acute-on-chronic liver failure.关键词：Acute-on-chronic liver failure;GFAP;AQP4;astrocyte;blood ammonia
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发布时间：2023-04-11 - 摘要：Objective To determine the influence of Qiguiyin Granules on the renal function and the relationship between the inflammatory response and autophagy in rats with acute kidney injury（AKI）caused by sepsis.Methods The sepsis model was established by using cecal ligation and puncture（CLP）in SD rats to induce AKI.They were divided into three groups:sham operation group,CLP group,CLP+Qiguiyin group with each group 6 rats.Each group was measured with the following indicators at the monitoring time:1.circulating indicators:blood pressure.2.renal function indicators:serum creatinine（sCr）,insulin-like growth factor binding protein 7（IGFBP7）,tissue matrix metalloproteinase inhibition Agent-2（TIMP2）.3.inflammation indicators:tumor necrosis factor-α（TNF-α）,TOLL-like receptor 4（TLR4）,c-Jun amino terminal kinase（JNK）,mitogen-activated protein kinase（MAPK）.4.autophagy indicators:LC3-I,LC3-II.Statistical analysis was performed using SPSS19.0 software.The mean of each group was tested by variance homogeneity test,and then multiple sets of mean ANOVA tests were performed.Results The blood pressure of the CLP group and the CLP+Qiguiyin group began to decrease at 12 h,but there was no significant change in the sham operation group.There was no significant difference in blood pressure between the CLP group and the CLP+Qiguiyin group.The serum creatinine in the CLP group and in the CLP+Qiguiyin group increased from 12 h,and were significantly different from the sham operation group.After 24 h,the CLP+Qiguiyin group had lower serum creatinine level than the CLP group.The product of IGFBP-7 and TIMP-2 began to increase significantly after 3 hours in the CLP group,while it in the CLP+Qiguiyin group was significantly lower than that in the CLP group.The levels of TNF-α in CLP group and CLP+Qiguiyin group at 3 h,6 h,12 h,24 h and 48 h were higher than those at 0 h.The levels of TNF-α in the CLP group and CLP+Qiguiyin group were higher than in the sham-operated group at 3 h,6 h,12 h,24 h and 48 h.The levels of TNF-α in the CLP+Qiguiyin group was lower than in the CLP group at 3 h,6 h,12 h,24 h and 48 h.TLR4 in the CLP group was higher than that in the sham operation group at 6 h,12 h and 24 h.There was no significant difference between the CLP+Qiguiyin group and the sham operation group at 6 h,but it was significantly different from the CLP group.Compared with the sham operation group,MAPK in the CLP group increased at 6 h,12 h and 24 h,and decreased in the CLP+Qiguiyin group compared with the CLP group.LC3 II/LC3 I in the CLP group was higher than the sham operation group.And at 12 h and 24 h,LC3 II/LC3 I in the CLP+Qiguiyin group was lower than the CLP group.Conclusion Qiguiyin Granules can improve sepsis in AKI.The change of sepsis in AKI is related to the inflammatory response,which is achieved through the TLR4 and MAPK pathways.Sepsis in AKI is also associated with circulatory perfusion,and autophagy is also the pathophysiological mechanism of sepsis in AKI.Although Qiguiyin Granules does not improve the mean arterial pressure,it can reduce autophagy by inhibiting the inflammatory response so as to benefit sepsis in AKI.关键词：Sepsis;acute kidney injury;autophagy;Qiguiyin Granules
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发布时间：2023-04-11 - 摘要：许彭龄教授,认为,痛风急性期多因饮食不节、高龄体弱等因素造成,水湿运化失常,湿浊污垢留滞于经络,可伴有气滞、寒凝、血瘀等病理产物,而以上病理产物的生成均与脾肾关系密切,故临床诊治时应重视先后天之本,以调理脾肾为主,从而起到祛湿化浊、通络止痛,达到"标本兼治"的目的。许教授遣方用药时以"和化法""苍麻汤"为主,临床随证化裁,从而起到推泄体内湿浊污垢,促进人体正常生理运转的作用;并运用"辛甘化阳,酸甘化阴"的配伍原则,调和人体阴阳以求平衡,灵活处理兼夹证候,临床效果显著。关键词：痛风,急性期;调理脾肾;许彭龄
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发布时间：2023-04-11 - 摘要：胃食管反流病是消化系统常见病。姚乃礼教授系中国中医科学院主任医师,国家第四、五、六批老中医专家经验继承工作指导老师,从事中医内科临床及研究工作40余载。姚教授认为气机失于调畅贯穿疾病始终,脾胃气机失调是其病理基础;在治疗中注重调畅脏腑气机,体现在健运脾气、润降胃气、疏理肝气、畅通腑气、肃降肺气、清化痰气6个方面。关键词：胃食管反流病;气机升降;姚乃礼
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发布时间：2023-04-11 - 摘要：贾立群教授在临床和科研实践中建立了中医临床舌象数据库,基于舌诊临床数据,结合中医理论对舌痛进行中医的辨证与分析。提出舌痛一症中医属络病范畴,病性属热,并以虚实为纲,重点论述舌痛的津亏络损、火热灼络、瘀血阻络3种病机,并针对病机给出以沙参麦冬汤和凉膈散为主的内服方、及自拟"舌痛含漱液"（红花、紫草、桂枝、白芷、麦冬）外治的治疗方法。关键词：舌痛;辨证;中医药治疗;贾立群
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发布时间：2023-04-11 - 摘要：慢性尿酸性肾病起病隐匿,临床表现常不突出,早期亦无肾损害相关实验室指标变化,难以引起重视,易错失最佳治疗时机,最终导致尿毒症,需进行肾脏替代治疗,严重影响患者生活质量。王暴魁教授认为慢性尿酸性肾病以肾气阴两虚,湿浊痰瘀痹阻肾络为主要病机,强调风邪在本病中的重要性;治疗上以补气养阴为主,兼以祛湿化痰、活血通络,祛风贯穿始终;主张分期论治,急性加重期以邪盛正虚为主,从痰热湿瘀夹风论治,兼以固本;稳定期以正虚邪恋为主,从气阴两虚论治,兼以祛邪。关键词：慢性尿酸性肾病;补气养阴;王暴魁
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发布时间：2023-04-11 - 摘要：复发性流产是指连续2次及以上发生自然流产的情况,临床就诊人数逐年增加。杜宝俊教授结合多年临床经验,从肾、肝、脾三脏辨证论治该病,以补肾为宗旨,惯用桑寄生、菟丝子、续断、杜仲、巴戟天等补肾安胎;在补肾的前提下顾护脾胃,选用山药、白术、茯苓、党参等健脾药物使先后天相互化生;运用黄芪、太子参等大补元气为前提,加当归、白芍、川芎等补血药物调和气血阴阳;同时运用西医手段监测孕妇激素水平、高凝状态、甲状腺功能等指标,并以B超检查明确胚胎发育状况,避免盲目保胎与宫外孕风险。杜教授提倡中西医结合的保胎思路,并注重通过调节情志提高疗效。关键词：复发性流产;补肾健脾;中西医结合;杜宝俊
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发布时间：2023-04-11 - 摘要：传统中医理论将疾病简单划分为"外感"和"内伤"两大类,按照此种分类方法,疾病发生、发展的规律应运而生,并且衍生出了一系列的治疗原则和治疗方法。随着社会的发展和医学的进步,外界环境的改变使得临床疾病谱发生了显著的变化,近年来一些热点疾病,尤其是感染性疾病往往呈现出较为特殊的发病方式,传统的医学理论在某些方面已经不能全面、严谨的概括此类疾病的病因、病机等内容,因此传统医学理论应随之拓展。本文通过收集临床资料并总结特点,结合解剖学、病理学、生理学相关内容,与传统理论进行对比,提出以"人体黏膜屏障"为界线区分"内""外",由新的界定标准赋予的新的临床意义。关键词：外感病;内伤病;治法
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发布时间：2023-04-11 - 摘要：荨麻疹是皮肤科常见的变态反应性疾病,典型表现为皮肤出现不同程度的瘙痒性风团,发无定处、骤起骤退,多病情缠绵、反复发作、易诊难治。现代中医皮肤科的奠基人和开拓者赵炳南名老中医,创立了中医皮肤科疾病辨证论治体系,对荨麻疹这一难治性皮肤病的辨证论治有独到的见解,认为风邪是主要致病条件,可夹寒夹热,风与寒热相合致病,风寒、风热之邪在一定条件下还可以互相转化;提出荨麻疹的治疗总则是疏散风邪、平调寒热、调和营卫、调理气血,赵老强调,荨麻疹临证当首辨寒热,以祛风为主,根据夹寒夹热的不同,或散寒或清热,以达到良好的疗效。在赵炳南先生的内治八法中,疏风解表止痒法的代表方剂即为"麻黄方"和"荆防方",分别对应荨麻疹的风寒和风热二证。关键词：赵炳南;寒热辨治;荨麻疹;麻黄方;荆防方
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发布时间：2023-04-11 - 摘要：儿童腺样体肥大、过敏性鼻炎、鼻-鼻窦炎及中耳炎是耳鼻喉科常见病,若不及时治疗,严重影响患儿的生活质量及心理健康。序贯疗法是在中药治疗的过程中,通过不同剂型的转换而达到药物利用度最大化的一种治疗手段,中医鼻病序贯疗法外治法由此演变而来。鼻病序贯疗法以独特的用药方法、安全且疗效可观等特点提升了鼻病患儿及其家长的用药接受度。关键词：小儿;耳鼻喉疾病;中医鼻病序贯疗法;经验
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发布时间：2023-04-11 - 摘要：老年性慢性阻塞性肺疾病（COPD）的发生发展与肺衰老密切相关。氧化应激是肺衰老的重要病理特征,而氧化和抗氧化失衡是老年性COPD病情进展的关键环节。结合老年性COPD氧化应激机制及中医毒邪理论、络病理论认为,老年性COPD的根本病机为肺络虚损,毒损肺络,病理因素为毒虚共存,提出益气排毒通络法贯穿老年性COPD疾病始末,为老年性COPD的诊疗提供了新的思路和理论依据。关键词：老年性慢性阻塞性肺疾病;肺衰老;氧化应激;毒损肺络
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发布时间：2023-04-11 - 摘要：更年期综合征是临床较为常见的病证,古代文献中并没有专篇详尽记述本病症,教材中对于本病症的治疗也不尽丰富,笔者在结合临床发现本病的病位在心、肝、脾、肾;主要病机可分为为肾虚肝郁和心脾两虚;治疗选用滋补肝肾、疏肝解郁的滋水清肝饮及益气补血、健脾养心的归脾汤,针对兼见的不通表现进行临证加减变化,缓解更年期综合征的伴随症状。关键词：更年期综合征;中医辨证;肾虚肝郁证;心脾两虚证
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发布时间：2023-04-11 - 摘要："脏腑风湿"是仝小林教授基于《内经》的"伏邪"和"痹证"理论提出的新学说,该学说指出风寒湿邪可通过"内传"和"直中"的途径侵袭脏腑,进而形成多类疑难杂症。依据该学说运用疏风、散寒、祛湿等方法透邪外出的治疗原则,临床运用乌头汤、五积散、麻黄升麻汤、小续命汤等经典名方,可治疗急性痛风性关节炎、颅脑术后慢性头痛、急性化脓性扁桃体炎、腰椎间盘突出症等"脏腑风湿病",疗效良好。关键词：脏腑风湿;乌头汤;麻黄升麻汤;小续命汤;五积散
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发布时间：2023-04-11 - 摘要：目的探讨重症医学科患者舌象、脉象特征与疾病预后的关系。方法提取首都医科大学附属北京中医医院医院信息系统中重症医学科2012年4月—2018年10月所有电子病历,分析患者一般信息、舌象特征、脉象特征、疾病转归预后等信息,用Logistic回归模型分析患者预后的影响因素。结果 1 119例患者死亡272例（死亡组）,转诊到普通病房847例（存活组）。2组舌有瘀斑、舌苔黄腻、舌暗伴瘀斑的比例比较差异有统计学意义（P<0.05）,2组脉沉、脉弦、脉滑、脉弱、脉结代、脉洪大比例比较差异有统计学意义（P<0.05）。多因素分析结果显示,苔腻、苔白腻、舌暗有瘀斑、脉沉、脉数、脉弱、脉结代的重症医学科患者死亡风险增加（P<0.05）。结论舌象和脉象特征对重症医学科患者预后有一定的预测作用。关键词：重症医学科;舌象;脉象;医院信息系统;疾病预后
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发布时间：2023-04-11 - 摘要：目的分析353例缺血性中风患者发病季节与证候要素、危险因素的关系。方法选取2015年2月—2019年2月作者所在医院脑病科收治的缺血性中风急性期患者353例,分析不同发病季节与其证候要素、常见危险因素的关系。结果痰湿证患者夏季发病率较高,内风证、内风+痰湿+血瘀组合证患者秋季发病率较高,内火证及内风+痰湿组合证患者冬季发病率较高。年龄≤65岁具有脑卒中家族史者夏秋季发病风险增加,合并高血压者秋冬季发病风险增加,合并颈动脉狭窄者冬季发病风险增加;年龄>65岁合并高血压者夏季发病风险增加,饮酒嗜好者秋季发病风险增加,合并血脂异常时冬季发病风险增加。结论缺血性中风患者发病季节规律与证候要素及危险因素均相关。关键词：缺血性中风;发病季节;证候要素;危险因素
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发布时间：2023-04-11 - 摘要：目的进行针刀联合封闭治疗肱骨外上髁炎临床疗效观察随访。方法收集2015—2017年门诊明确诊断为肱骨外上髁炎患者90例,按照随机序数列表分为针刀组、封闭组、针刀+封闭组3组,各30例:针刀+封闭组予针刀联合封闭治疗,针刀组予单纯针刀治疗,封闭组予单纯封闭治疗,采用疼痛评分VAS进行对比临床疗效。结果治疗1周后针刀+封闭组与单纯针刀组、单纯封闭组在静息疼痛、活动疼痛、压痛、患者对治疗反应、医生对治疗反应指标方面有差异,提示治疗1周后针刀+封闭组优于单纯针刀组及单纯封闭组;治疗1周后针刀+封闭组与单纯针刀组、单纯封闭组在肿胀、患处功能改善指标方面无差异,提示尚不能认为针刀+封闭组优于单纯针刀组及单纯封闭组。治疗1周后单纯针刀组与单纯封闭组在静息疼痛、活动疼痛、压痛指标方面有差异,提示单纯针刀组优于单纯封闭组;治疗1周后单纯针刀组与单纯封闭组在肿胀、患处功能改善、患者对治疗反应、医生对治疗反应指标方面无差异,提示尚不能认为单纯针刀组优于单纯封闭组。结论针刀联合封闭治疗肱骨外上髁炎操作相对简单、创伤小、痛苦小、近期效果好,是一项值得借鉴的中西医结合适宜技术。关键词：随机;针刀;封闭;肱骨外上髁炎;VAS评分
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发布时间：2023-04-11 - 摘要：目的探讨血府逐瘀汤加减治疗腘动脉硬化闭塞症术后的临床疗效。方法回顾性分析2018年1月—2018年12月收治的100例以症状型腘动脉狭窄或闭塞病变为主且腘动脉病变血管腔内重建术后中医辨证为脉络瘀阻型患者,根据是否口服中药（血府逐瘀汤）分为中药组58例患、对照组42例,比较术后6个月、12个月2组患者中医症候评分、Rutherford分级、踝肱指数（ankle brachial index,ABI）情况。结果术后患者在总有效率、ABI及Rutherford分级方面较术前均有所改善（P<0.05）。术后6个月两组对比在ABI方面,中药组为0.94±0.05,对照组为0.85±0.05,中药组明显高于对照组（P<0.05）;在Rutherford分级方面,中药组为3.07±0.03较对照组3.34±0.06明显改善（P<0.05）;术后12个月两组对比,、在ABI方面,中药组为0.78±0.02,、对照组为0.69±0.07,,中药组优于对照组（P<0.05）;在Rutherford分级方面,中药组为3.31±0.02与对照组的3.45±0.01对比具有明显优势（P<0.05）;总有效率方面,中药组为91.3%,明显高于对照组的72.9%（P<0.05）。结论治疗腘动脉硬化闭塞症术后脉络瘀阻型患者,基础用药联合血府逐瘀汤加减临床治疗效果较好。关键词：血府逐瘀汤;腘动脉;腘动脉粥样硬化闭塞症;腔内治疗;脉络瘀阻型
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发布时间：2023-04-11 - 摘要：目的探讨中药口腔护理集束化措施在机械通气患者中的应用。方法纳入2015年12月—2019年3月ICU住院接受机械通气治疗的患者59例,按照随机数字表法将其分为观察组和对照组,对照组31例接受常规口腔护理,观察组28例采取中药口腔护理集束化护理措施,分析2组患者口腔情况及机械通气相关肺炎（VAP）的发生率。结果观察组患者口腔破溃出血及VAP发生率分别为7.14%、0,均低于对照组的29.03%、16.13%,差异有统计学意义（P<0.05）。结论中药口腔护理集束化措施能够有效降低应用机械通气患者口腔破溃出血的发生率,预防VAP的发生。关键词：中药;口腔护理;集束化;呼吸机相关肺炎
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发布时间：2023-04-11 - 摘要：白芍为常用中药品种,且为安徽、四川、浙江、内蒙古等地区重要经济作物之一,其制成品白芍饮片的安全性应受到重视。通过整理比较相关质量标准发现,对于农药残留、重金属、二氧化硫、苯甲酸等毒性成分以相适应的方法与范围进行追踪检测,可以保证用药安全,同时指导白芍合理种值。关键词：白芍;检测;农药残留;重金属;二氧化硫;苯甲酸;黄曲霉毒素
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发布时间：2023-04-11 - 摘要：目的建立快速、简便、有效检测黄芪饮片质量是否符合《中华人民共和国药典（2015）》标准的方法,以提高饮片质量检验效率。方法通过正交试验确定获得黄芪水浸液的最佳方法和条件,采用紫外-可见分光光度法,在一定波长下测定10批黄芪水浸液的吸光度,将不同波长下的吸光度与水溶性浸出物含量进行Spearman相关分析,以确定检识波长;采用Spearman相关分析法进行检识波长下的吸光度与主要指标成分含量的相关性检验。结果正交试验结果显示,在室温下100 nL水浸泡4 g黄芪粉末（二号筛）20 min,水浸液的吸光度可达到峰值。该样品水浸液在260 nm的吸光度与水溶性浸出物含量相关,相关性有统计学意义（P=0.0158）;与黄芪甲苷亦相关,相关性有统计学意义（P=0.004）。吸光度<1.071的黄芪样品质量不符合《药典》标准。结论上述浸提方法最快速、简便,获得的黄芪水浸液吸光度能够反映饮片水溶性浸出物含量和主要指标性成分含量,可以简化药房饮片检验的步骤。关键词：黄芪;水溶性浸出物;黄芪甲苷;紫外-可见分光光度法;快速质量评价
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发布时间：2023-04-11 - 摘要：目的探讨中药（包括中药注射液、中药饮片及中成药）相关性肝损伤不良反应病例的患者基本情况、用药情况、药物成分及归经情况和对发生不良反应的影响,为临床合理用药提供参考。方法检索北京市药品不良反应中心数据库,对2015—2017年中药相关性肝损伤不良反应病例报告进行统计分析。结果共检索到中药相关性肝损伤不良反应病例101例;共涵盖中药102种,有明确肝毒性成分的药物79个;联合用药导致肝毒性叠加的57例等。结论临床应加强中药不良反应监测,严格按照说明书规定用药,以降低不良反应发生风险。关键词：中药;肝损伤;药品不良反应
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发布时间：2023-04-11
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