摘要:Objective To explore the medication rule of TCM programs for the prevention and treatment of COVID-19 in all areas of China through analyzing relevant TCM data.Methods TCM prescriptions involved in TCM programs for the prevention and treatment of COVID-19 of the National Health Commission,all provinces,municipalities and autonomous regions with the deadline of 8 February 2020 were collected,by using the software of Microsoft Excel 2016,IBM SPSS 15.0,SPSS Modeler 18,data mining methods such as software screening statistics,association rule analysis,cluster analysis,etc.were applied to make statistical analysis on the medication frequency,four-qi,five-flavor,meridian tropism and distribution,efficacy classification,and prescription rules of the drugs involved in these prescriptions,and sum up the medication rules of TCM scheme for preventing and treating COVID-19 in various regions of the country.Results 159 prescriptions were included.It was found that in TCM programs for the prevention and treatment of COVID-19,drugs with warm nature were used mainly with the five flavors of bitter,sweet and pungent,and mainly belonged to the lung,spleen and stomach meridians.The frequently used drugs were Liquorice,almond,ephedra,gypsum,agastache,Scutellaria,astragalus,Atractylodes,honeysuckle,forsythia,Atractylodes; The most commonly used drug pairs were ephedra with almond,ephedra with gypsum,patchouli with mangnolia officinalis,atractylodes with fructus amomi,honeysuckle with forsythia,lepidium seed with gypsum,fructus amomi with ephedra.Besides,six prescriptions for the prevention and control were developed.Conclusion Resolving dampness and detoxicating were taken as the basic methods of TCM programs for the prevention and treatment of COVID-19,the condition of cold will be warmed and dissolved,the hotness will be drained,and it is also taken into account that the treatment of dispersing lung and relieving asthma,invigorating qi and strengthening spleen,nourishing yin and producing fluid and regulating qi and activating blood circulation to comprehensively can adjust the patient’s body state.
关键词:COVID-19;TCM program for prevention and treatment;medication rule
摘要:Objective To evaluate the clinical efficacy and safety of Yiqi Gushen Tongluo Recipe in the treatment of early diabetic kidney disease(DKD)with deficiency of qi and Yin and stagnation of kidney collaterals.Methods 90 cases of patients meeting the criteria were included and randomly divided into treatment group and control group,45 cases each.All patients were treated with conventional western medicine,and the treatment group was supplemented with Yiqi Gushen Tongluo Recipe.After 12 weeks of treatment,serum creatinine(SCr),and estimated glomerular filtration rate(eGFR),urinary albumin excretion rate(UAER),urinary albumin creatinine ratio(UACR),superoxide dismutase(SOD),malondialdehyde(MDA),hypersensitive c-reactive protein(hs-CRP),transforming growth factor β1(TGF-β1),and TCM syndrome score and efficiency were evaluated,and the mechanism of their actions were preliminarily discussed.Results The effective rate was 93.33% in the treatment group and 73.33% in the control group.SCr and eGFR were decreased after treatment,but the difference was not statistically significant(P > 0.05).The changes of UAER,UACR and TCM syndrome score in the treatment group were significantly better than those in the control group,with statistically significant differences(P<0.05).Serum SOD level in the treatment group was significantly higher than that in the control group(P<0.05).Serum levels of MDA,hs-crp and TGF-β1 were significantly lower than those of the control group(P<0.05).No obvious adverse reactions occurred during the test.Conclusion Yiqi Gushen Tongluo Recipe can significantly improve the clinical symptoms of early DKD patients with deficiency of qi and Yin and stasis of kidney collaterals,reduce the level of urinary protein,and improve the renal function.Its mechanism may be related to the improvement of the oxidative stress and micro-inflammatory response of the body.
关键词:Early diabetic kidney disease;Qi and Yin deficiency;stasis of kidney collateral syndrome;Yiqi Gushen Tongluo Recipe
摘要:Objective To explore the mechanism of Radix saposhnikoviae in treating stroke of attack of collateral based on mining the rules in ancient TCM prescriptions.Methods TCM prescriptions for stroke of attack of collateral were retrieved in China Prescription Database of the Institute on Information of Traditional Chinese Medicine,China Academy of Chinese Medical Sciences from 10 June 2019 to 15 June 2019. Stroke target information came from GeneCards database. The highest frequency herbs were selected and submitted to BATMAN-TCM system to make system biology analysis by mining the prescription database using frequency analysis. Results The frequency of Radix saposhnikoviae was the highest among the drugs for stroke of attack of collateral. So Radix saposhnikoviae was used for prediction in system biology. The result suggested that 28 components of Radix saposhnikoviae could act on a total of 153 target in treating stroke of attack of collateral, and the key targets were concentrated on SCN and CHRNA. Bioinformatics analysis showed that the main function of them was to regulate ion channel or neuroligand activity. Conclusion Radix saposhnikoviae can affect neuronal voltage gating by regulating ion channels to achieve nerve repair; or by regulating the activity of cholinergic receptors, to impact the nerve immune function and delay the process of brain injury.
关键词:Stroke;attack of collateral;Radix saposhnikoviae;mechanism;data mining
摘要:Objective To analyze Professor LIU Hong-xu’s TCM medication characteristics and prescription rules for patients after percutaneous coronary intervention(PCI)based on data mining.Methods Collect prescriptions for patient after PCI prescribed by Professor LIU Hong-xu from January 1,2013 to December 31,2018 in the Beijing Hospital of TCM,and establishing a database of TCM formulas.Frequency statistics,association rules analysis,system cluster analysis were conducted.Results There were totally 489 formulas included involving 162 kinds of herbal medicines and 47 kinds with the appearance frequency no less than 10%.There were 135 correlations obtained from association rules analysis and 13 combinations obtained from clustering analysis.Conclusion Professor LIU Hong-xu treats patients after PCI by combining several prescriptions according to monarch drug,minister drug,assistant drug and servant drug; at the same time,he is good at using paired drugs and takes tonifying qi and yin as the major treatment principle,and eliminating stasis and resolving phlegm as the basic principle,accompanied by invigorating the spleen and draining the lung,soothing the liver and tranquilizing the mind.