Hemopathy Branch of China Association of Chinese Medicine,Cancer Professional Committee of China Association of Integrated Traditional Chinese and Western Medicine,Cancer Professional Committee of Beijing Society of Integrated Traditional Chinese and Western Medicine
摘要:Objective To summarize and analyze the characteristics of cough,expectoration and asthma in 138 patients with chronic fibrotic interstitial lung disease(CF-ILD). Methods The study enrolled patients with CF-ILD who were treated in the Respiratory Department of Beijing Traditional Chinese Medicine Hospital from October 2016 to December 2018. All patients filled the TCM syndrome scale in order to collect the characteristics of TCM symptoms they had,including cough,expectoration and asthma. Results The characteristics of cough of CF-ILD patients were severe cough in winter(54.62%) and more severe when smelling oil fume odor(78.46%). The common accompanied symptoms of cough were shortness of breath(53.08%), suffocation of the chest(44.62%) and chest tightness(23.85%). The characteristics of expectoration are less sputum(60.77%), sticky phlegm(56.92%) and white sputum(66.15%). The most common manifestations of asthmatic breath were shortness of breath after exertion(87.69%), shallow and fast breathing(75.38%) and insufficient breath(66.92%). Conclusion The characteristics of cough,expectoration and asthma in patients with chronic fibrotic interstitial lung disease are significantly heterogeneous compared with other respiratory diseases,which should be identified in clinical practice.
摘要:Objective To explore the medication rules of Chinese medicine used for oral mucositis caused by radiotherapy and chemotherapy. Methods Articles about Chinese medicine used for oral mucositis caused by radiotherapy and chemotherapy were searched on CNKI,Wanfang Data and VIP Network published from the establishment of these databases to July 2019,then, Excel,R-studio,SPSS 20.0 and other tools were used to make the association rule analysis and factor analysis for the inclusive drugs. Results There were 75 prescriptions and 155 kinds of Chinese herbal medicines which conform to the inclusive criteria.Among them,there were 11 kinds of herbal medicines with the frequency greater than or equal to 10,mainly with the nature of bitter cold and sweet cold.To make analysis of the association rules on these 11 kinds of Chinese medicines,it was revealed that there were 14 pairs with higher improvement.To make association rule analysis of 10 Chinese medicines without licorice with the frequency greater than or equal to 10, it was found that the improvement was high in all. 4 common factors were extracted by factor analysis. Conclusion The herbal medicines used in the TCM treatment of oral mucositis caused by radiotherapy and chemotherapy mainly have the functions of clearing away heat and detoxifying,nourishing Yin and promoting the production of body fluid,activating blood circulation,promoting regeneration of muscle and stopping pain.
关键词:Chemoradiotherapy oral mucositis;malignant tumor;traditional Chinese medicine treatment;association rules;factor analysis;regulations of drug-use
摘要:目的利用Meta分析法评价中医外治法治疗急性放射性皮炎的临床疗效。方法采用计算机检索Cochrane Central、PubMed、EM-BASE、Web of Science、Science Direct、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、维普中文科技期刊全文数据库(VIP)、万方数据知识服务平台(WANFANG DATA)、读秀学术搜索数据库、百链学术搜索数据库,筛选出中医外治法治疗急性放射性皮炎的随机对照临床试验,由2名研究者独立筛选文献、提取资料并对纳入研究进行偏倚风险评估后,用Rev Man 5.3软件进行Meta分析。结果筛选出文献280篇,根据文献纳排标准,共排除263篇,最终纳入17项临床研究,共计1 453例患者,其中试验组736例,对照组717例。与西药组比较,中医外治法能显著提高急性放射性皮炎的临床有效率[RR=1.27,95%CI(1.17,1.39),P<0.01]。预防性用药能显著改善患者症状,中医药外治较西药组预防重度放射性皮肤损伤的发生效果更优[RR=0.25,95%CI(0.16,0.38),P<0.01],但对于预防轻度放射性皮肤损伤的发生中医药外治可能劣于西药组[RR=1.17,95%CI(1.03,1.33),P=0.02]。对于急性放射性皮炎反应评分,中医外治及西药组在一定程度上均能降低其评分,差异无统计学意义[MD=-1.67,95%CI(-4.41,0.79),P=0.18]。中医药外治能有效缩短临床治愈时间[MD=-4.28,95%CI(-6.18,-2.38),P<0.01],能在一定程度上提高患者生活质量[MD=3.17,95%CI(0.15,7.27),P=0.04],但仍需更多研究证实。另外根据文献报道,中医药外治在改善皮肤损伤所致疼痛方面有一定优势(P<0.05),但仍需更多数据支持。结论基于目前的研究,中医药外治法对于急性放射性皮炎具有一定的治疗效果,无论在皮损状态亦或是患者相关症状改善等方面,均表现出了一定的积极作用,但是由于纳入研究质量不高,数量较少,因此需要更多高质量、大样本、多中心的随机对照研究进一步验证其疗效,从而为临床提供更高质量的循证医学证据。