摘要:Objective To explore the correlation between TCM classification of deficiency syndrome and cardiac structure, function and blood NT-proBNP in elderly patients with hypertension and left ventricular hypertrophy(LVH).Methods 118 cases of elderly patients with hypertension LVH were divided into Yin deficiency group, Yang deficiency group and Yin and Yang deficiency group according to TCM syndrome differentiation.The indexes of Cardiac Ultrasonic structure(LAD,LVEDD,LVMI),cardiac function(EF,FS,E/a)and blood NT proBNP levels in each group were compared.Results Ultrasonic structural index of heart: compared with Yin deficiency group, LVEDD and LVMI of yin and yang deficiency group and yang deficiency group increased, and the difference was statistically significant(P<0.05); compared with Yin deficiency group, LAD of yin yang deficiency group had upward tendency.Compared with Yang deficiency group, LVMI in the Yin and Yang deficiency group showed an upward trend, and the difference was statistically significant(P<0.05).Heart function index: compared with Yin deficiency group, E/A of yin and and yang deficiency group and Yang deficiency group decreased, NT proBNP increased, the difference was statistically significant(P<0.05); compared with Yin deficiency group, and EF/FS of the Yin and Yang deficiency group decreased; compared with Yang deficiency group, NT proBNP of Yin Yang deficiency group increased, and the difference was statistically significant(P<0.05).Conclusion Left ventricular dilatation and left ventricular hypertrophy are more significant in elderly hypertensive LVH patients with deficiency syndrome than those with Yin deficiency syndrome; left atrial enlargement may suggest an cardiac structural manifestation of heart Yang damage in elderly hypertensive LVH patients, and left ventricular mass index may indicate the duration of heart yang deficiency; NT proBNP can reflect the deterioration of heart function, and indirectly indicate the evolution and damage degree of heart Yang deficiency in TCM pathogenesis of hypertension LVH.
关键词:Senile hypertension;left ventricular hypertrophy;TCM syndrome type
摘要:Objective To evaluate the effect of Shufeng Jiedu Capsule on patients with acute exacerbation chronic obstructive pulmonary disease(AECOPD).Methods Ninety-three patients with AECOPD treated in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from October 2018 to December 2019 were randomly selected into control group and observation group according to the admission time.Finally, there were 46 in the observation group and 47 in the control group.The control group was given the routine treatment recommended by COPD guidelines.The observation group was treated with Shufeng Jiedu Capsule and the basic routine treatment.The TCM symptom scores and laboratory test index of the patients were observed and measured before and after the treatment.Results Compared with the control group, the effect of the observation group was better.After treatment, the efficacy level of the test group was better than the control group(P <0.05); TCM syndrome score, the scores of CAT,mMRC questionnaire, sputum score were more obviously alleviated(P<0.05),mucin(MUC5 AC)in sputum, serum NE,IL 8,CRP,and N% were better(P<0.05).Conclusion Shufeng Jiedu Capsules combined routine treatment can improve the clinical effect of AECOPD.Shufeng Jiedu Capsules may effectively improve the clinical symptoms and signs, inhibiting airway inflammation and high secretion of airway mucus in AECOPD.
关键词:Shufeng Jiedu capsule;acute exacerbation of chronic obstructive pulmonary disease;airway mucus
摘要:Objective To evaluate the clinical efficacy of suspension moxibustion combined with acupuncture treatment for knee osteoarthritis(KOA).Methods Seventy-five confirmed cases of KOA from March 2017 to December 2019 were randomly divided into acupuncture group(25 cases),acupuncture-suspension moxibustion group(25 cases)and microneedle group(25 cases),after excluding shedding cases, 21 cases were included in acupuncture group, 21 cases in acupuncture suspension moxibustion group and 20 cases in microneedle group.The acupuncture group was only treated with needling.The acupuncture-suspenson moxibustion group received acupuncture combined with suspension moxibustion.Mircroneedle group received shallow puncturing on the non-point location.All three groups were punctured with 30 min retention of needle, once every two days, three times every week, and totally 4 weeks were given.The western Ontario and McMaster University Osteoarthritis Index(WOMAC)score and total effective rate were compared among the three groups.Results The scores of WOMAC and the total effective rate of acupuncture group and acupuncture-suspension moxibustion group after the treatment was reduced compared with that before the treatment(P<0.05),also lower than that of microneedle group(P<0.05).The score of WOMAC and total score of the acupuncture-suspension moxibustion after the treatment were lower than those in the acupuncture group, but the differences were not statistically significant(P>0.05).The totoal effective rate of the acupuncture group and the acupuncture-suspension moxibustion group were higher than that of the microneedle group(P<0.05),but the differences were not statistically significant(P>0.05).Conclusion Both single acupuncture and suspension moxibustion combined with acupuncture are effective in the treatment of KOA.
摘要:Objective To observe the clinical effect of Bushen Tongluo Recipe combined with methotrexate in the treatment of liver-kidney Yin deficiency type of rheumatoid arthritis and the effect on serum cytokines.Methods 64 patients with liver-kidney Yin deficiency type of rheumatoid arthritis were randomly divided into treatment group and control group, each group was 32 cases, but 61 cases actually completed with 31 cases in the treatment group and 30 cases in the control group.Both two groups were given the basic treatment with methotrexate, and the treatment group was added with Bushen Tongluo Recipe, 2 times a day, 1 bag each time.The course of treatment was 12 weeks.After the course of treatment finished, the changes of serum cytokines IL-1β,IL-2 R,IL-6,IL-8,IL-10 and TNF-α in 2 groups were observed.Results The total effective rate was 83.87%(26/31)in the treatment group, better than that in the control group which was 50.00%(15/30),indicating statistically significant difference(P<0.05).Compared the same group before and after the treatment, the levels of IL-6 and TNF-α in the treatment group was decreased(P<0.05),but better than those in the control group in same period(P<0.05).Conclusion Bushen Tongluo Recipe combined with methotrexate is effective in the treatment of liver-kidney Yin deficiency type of rheumatoid arthritis, and can reduce the levels of cytokines IL-6 and TNF-α.
摘要:目的了解目前中医药与中西医结合领域下的2型糖尿病合并冠心病的研究现状、研究热点及研究趋势。方法以中国知识资源总库(CNKI)为中文数据来源,"中医学""中药学""中西医结合"文献分类目录下,主题为"糖尿病合并冠心病"或"糖尿病性冠心病"或"糖尿病伴冠心病"的相关文献,英文数据库选择Web of Science为数据来源。选择应用Excel进行描述性统计,应用CiteSpace V 5.5.R2进行作者、研究机构的合作网络分析,关键词共现分析、聚类分析。结果共纳入文献439篇,涉及期刊166种。作者共有901位,合作网络分析共得到53个节点、74条连线,其中核心作者共有22位。机构间的合作网络分析得到28个节点、6条连线。关键词共现分析得到62个节点、102条连线,高中心性的关键词有9个、突现词16个。关键词聚类分析得到有意义的聚类共8个。结论文献数量呈总体上升趋势。作者、研究机构的合作比较局限。研究内容主要围绕治法、药物及结局指标展开。研究类型以临床观察、文献研究为主。研究热点是中医证候、药物、治法与疗效。益气养阴活血药、益气养阴活血法或者中医证候研究是未来的研究趋势。