最新刊期
期 5 ， 2021
- 摘要：基于目前中医药或中西医结合治疗急性髓细胞性白血病（AML）文献分析,并通过长期临床实践,提出"中医药防治AML一体化研究"概念与诊疗策略,主要内容包括:强化导致AML的前期疾病骨髓增生异常综合征（MDS）的治疗,以阻止或延缓疾病向AML转化;治疗复发难治或耐药AML,提高临床完全缓解率;控制AML相关症状或并发症,促进疾病康复;制定和优化以AML为中心的中医综合诊疗方案与康复计划,使更多的AML患者在诊疗过程中获益。但到目前为止,"中医药防治AML一体化研究"的重要性和临床应用价值尚未被高度重视,现有文献证据级别有限,很难形成被行业领域公认的专家共识或诊疗方案。因而,制定顶层设计方案,开展全国大协作的规范化临床研究是获得更多循证医学证据的关键,也是中医药治疗AML领域未来研究的重点。关键词：急性髓细胞性白血病;中医药;一体化研究;骨髓增生异常综合征;复发难治急性髓细胞性白血病
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发布时间：2023-04-10 - 摘要：肿瘤化疗相关性血小板减少症（chemotherapy-related thrombocytopenia,CIT）为肿瘤化疗常见不良反应,发生率与肿瘤类型、治疗方案和化疗周期等密切相关。CIT不仅能导致化疗药物使用剂量降低或化疗时间延迟,从而降低肿瘤治疗效果,影响患者预后和生存质量。同时,因增加血小板输注与血小板刺激因子的临床应用,治疗费用大幅增加。因此,对存在出血高危因素的患者进行一、二级预防,有助于降低CIT发生率和严重程度。基于中医"治未病"与"既病防变"理论,中医药参与CIT全程治疗具有重要临床意义。由中华中医药学会血液病分会、中国中西医结合学会肿瘤专业委员会、北京中西医结合学会肿瘤专业委员会组织中医与中西医结合专家制订本共识,旨在为临床医师提供更合理的CIT诊疗方案,保障肿瘤化疗顺利实施,提升外周血血小板数值,改善CIT患者临床症状,从而提高生存质量。关键词：肿瘤;化疗;血小板减少症;中医药;专家共识
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发布时间：2023-04-10 - 摘要：Objective To observe the improvement of Yisui Granules for anemia and related symptoms in patients with low-and intermediate-risk type Ⅰ myelodysplastic syndromes（ MDS）.Methods With randomized double-blind,placebo-controlled research method,48 patients with low-and intermediate-risk type Ⅰ MDS were randomly divided into treatment group and control group,with 24 cases in each group.The treatment group was treated with Yisui Granules,1 bag/time,2 times/d,together with the basic western medicine treatment; the control group was treated with the placebo together with the western medicine basic treatment,1 bag/time,2 times/d,continuous treatment for 8 weeks.After the treatment,short-term efficacy indicators,including blood routine,anemia related symptoms and fatigue degree before and after the treatment were analyzed.Results After the treatment,the hemoglobin level of the treatment group was increased in comparison with that before the treatment,and was also significantly higher than that of the control group（ all P < 0.05）.After the treatment,the total effective rate of the treatment group was higher than that of the control group（ P <0.01）,and the clinical symptoms scores of the treatment group were lower than those before the treatment and the control group（ P <0.001 or P < 0.05）.After the treatment,the symptom of dizziness in the treatment group was better than that before the treatment,the symptoms of shortness of breath,fatigue,dizziness,and numbness in the treatment group were better than those in the control group（ P < 0.01 or P < 0.05）.After the treatment,the total effective rate of fatigue in the treatment group was higher that of the control group and also lower than that before the treatment（ all P < 0.01）.Conclusion Yisui Granules can increase the hemoglobin level of patients with low-and intermediate-risk type Ⅰ MDS,and improve the patients’ symptoms and fatigue.关键词：Yisui Granules;myelodysplastic syndromes;hemoglobin;anemia;fatigue;symptom
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发布时间：2023-04-10 -
Mechanism of indirubin and tanshinone Ⅱa in promoting degradation of mutant PMLA216T-RARα by realgar
摘要：Objective To explore the mechanism of Indirubin and tanshinone Ⅱa in promoting the degradation of mutant PMLA216TRARα by realgar.Methods Different concentrations of realgar were acted on wild type and mutant PMLA216T-RARα to observe the degradation of PML-RARα in two groups of cells to verify that PMLA216T-RARα is resistant to arsenic.The concentration of each component was determined according to the IC50 value measured by CCK8,and different concentrations and different combinations of realgar,indirubin,and tanshinone Ⅱa were used to act on the transfected PMLA216T-RARα cells.Western blotting was used to detect the effects of single use,pairwise combination and triple combination on PML-RARα degradation and autophagy-related factors（ pm TOR,LC3 B）.The proteasome inhibitor carfilzomib and the autophagy inhibitor bafilomycin A1 were used to detect the degradation of PML-RARα in each group of cells by Western blotting.Results Compared with the control group（ without drug intervention）,when the concentration of realgar was 0.5 μmol/L,which was acted on PML-RARα wild type and mutant PMLA216T-RARα,the expression of PML-RARα were significantly degra ded（ both P < 0.01）.Moreover,the comparison between the groups showed that the expression of PML-RARα of mutant PMLA216T-RARα was higher than that of wild type（ all P < 0.01）.Compared with the control group,when realgar was 4 μmol/L,indirubin was 8 μmol/L,and tanshinone Ⅱa was 8 μmol/L,and were acted on PMLA216T-RARα respetively,they could all degrade PML-RARα（ all P < 0.01） and reduce the level of p-mTOR（ all P < 0.01）,increase the level of LC3 B（ P < 0.05 or P < 0.01）.The above effect was the strongest when realgar + tanshinone Ⅱa + indirubin was combined（ P < 0.01）.Compared with the control group,when realgar + tanshinone Ⅱa + indirubin,realgar + tanshinone Ⅱa + indirubin + carfilzomib were used on PMLA216TRARα,PML-RARα were significantly degraded（ all P < 0.01）.Compared with the control group,carfilzomib alone,bafilomycin A1 alone,realgar + tanshinone Ⅱa + indirubin + bafilomycin A1,when acting on PMLA216T-RARα,all caused PML-RARα to a significant accumulation,and the expression of PML-RARα in the realgar + tanshinone Ⅱa + indirubin + bafilomycin A1 group was higher than that in the carfilzomib alone and bafilomycin A1 group（ all P < 0.01）.Conclusion The combination of indirubin and tanshinone Ⅱa can enhance the degradation effect of realgar on mutant PMLA216T-RARα through autophagy,and the combination of the three has the strongest autophagy effect,which may be one of the mechanisms of Chinese medicinal formula Realgar-Indigo naturalis in the treatment of acute promyelocytic leukemia.关键词：Realgar;indirubin;tanshinone Ⅱa;acute myeloid leukemia;autophagy;PML-RARα;gene mutation;protein degradation- 2
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发布时间：2023-04-10 - 摘要：骨髓增生异常综合征（MDS）是一种克隆性骨髓造血干细胞疾病,其特点是无效和异常造血导致的外周血细胞减少,约1/3的患者转变为急性髓细胞性白血病（AML）。高危型MDS治疗效果差,生存期短,更容易转化为AML。青黄散/复方青黄散属于口服含砷中药制剂,多年来一直是中国中医科学院西苑医院治疗MDS的有效药物,青黄散/复方青黄散治疗高危MDS疗效确切,其疗效与血砷浓度相关,临床应用安全性高。青黄散/复方青黄散治疗高危MDS的效应机制主要集中在抑制细胞增殖、诱导凋亡、促进红细胞分化、调节异常DNA甲基化、调节细胞免疫、调控TP53/p VHL/HIF1A信号通路等方面。青黄散/复方青黄散疗效好、安全性高、口服方便、无需化疗、节约成本、居家服药、提高生活质量,是MDS治疗的理想药物。关键词：骨髓增生异常综合征，高危型;急性髓细胞性白血病;青黄散;复方青黄散;砷
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发布时间：2023-04-10 - 摘要：<正>"金镶玉"检验医学论坛是由北京中西医结合学会、湖南省中医药学会、湖南省中西医结合学会、重庆市中西医结合学会三地检验医学同仁联合发起主办的学术论坛,论坛采用三地简称京、湘、渝谐音命名为"金镶玉"检验医学论坛。论坛采用三地轮值举办制,从2017年起每年10—12月举办,为检验医学工作者搭建学术交流平台。第一届"金镶玉"检验医学论坛于2017年在重庆举办,同时开展青年医技师演讲大赛,我学会7名代表有6名获得奖项（一等奖1名、二等奖2名、3等奖3名）,来自三地的代表500余人参加了会议。
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发布时间：2023-04-10 - 摘要：Objective To explore the effect of Yizhi Jiedu Decoction on the learning and memory ability,glucose and lipid metabolism and insulin secretion in diabetic rats.Methods Forty-eight SD rats were randomly divided into normal control group,diabetes model group,low-dose,medium-dose,high-dose Yizhi Jiedu Decoction groups,and donepezil hydrochloride groups,each with eight rats.Except for the normal control group,the other five groups were given a high-sugar and high-fat diet combined with streptothricin to induce diabetes.low-dose,medium-dose,high-dose Yizhi Jiedu Decoction groups were given orally by 0.9,1.8,3.6 g/（ kg·d） respectively,donepezil hydrochloride group was given donepezil hydrochloride by 0.45 mg/（ kg · d）.After four weeks of continuous gastric gavage,the rat body weight,fasting insulin（ FINS）,fasting blood glucose（ FBG）,serum total cholesterol（ TC）,low-density lipoprotein cholesterol（ LDL-C）,high-density lipoprotein cholesterol（ HDL-C）,and triglycerides（ TG） were measured, and the behavioral changes of rats and the pathological changes of hippocampal neurons were observed.Results Compared with the diabetes model group,the weight of the rats in the high-dose Chinese medicine group was controlled（ P < 0.05）,FBG,TG,and LDL-C were significantly reduced（ P < 0.01,P < 0.05）; the rats’ escape latency was significant shortened（ P < 0.05）,and the number of crossing platforms increased（ P < 0.05）; pathology suggested that the nucleus pyknosis was decreased,the number of degenerated necrotic cells decreased,and the number of Nissl bodies increased.Conclusion Yizhi Jiedu Decoction can significantly improve the glucose and lipid metabolism disorder,promote the secretion of insulin,and improve the cognitive dysfunction of diabetic rats.关键词：diabetes;Yizhi Jiedu Decoction;cognitive dysfunction;glucose and lipid metabolism;rat
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发布时间：2023-04-10 - 摘要：Objective To observe the protective effect of Qihuo Yin on muscle tissue of rats after acute exhaustive exercise and its influence on behavioral changes,and to explore its anti-fatigue mechanism.Methods Eighteen male Sprague-Dawley rats were randomly divided into blank control group,model group and the Qihuo Yin group,with 6 rats in each group.Treadmill exercise was used to establish exhaustive exercise fatigue model of rats.The blank control group was given the same volume of normal saline by gavage once a day as the rats in the model group,and the rats in the Qihuo Yin group were given Qihuo Yin by gavage once a day; the course of treatment was 7 consecutive days for all groups.The blank control group were not given any training.The rats in the model group and the Qihuo Yin group were given treadmill training for 30 minutes（ 15-30 m/min） 30 minutes after gavage for 6 consecutive days,and on day7,they were given treadmill training with a speed of 30 m/min.Exhaustive exercise time was recorded for the rats in the model group and the Qihuo Yin,and the serum levels of creatine kinase（ CK）,lactate dehydrogenase（ LDH）,lactic acid（ LA）,urea nitrogen（ BUN） were measure.At the same time,the behavioral changes of rats were observed.Results Compared with the blank control group,the levels of serum LDH,LA,CK,BUN in the model group were significantly higher than those in the blank control group（ P< 0.01）.Compared with the model group,the exhaustive exercise time of rats in Qihuo Yin group was significantly longer than that in the model group（ P < 0.01）,and the levels of serum LDH,LA,CK,BUN were significantly lower than those in the model group（ P <0.05）; there was no significant change in the incubation period of the rats rotating rod test animals in the Qihuo Yin group,but the activity latency of the total area of the autonomic activity reaction box was significantly prolonged（ P < 0.05）.Conclusion Qihuo Yin can significantly prolong the exhaustive exercise time of rats and have an effect on the autonomic activity of rats.It plays an anti-fatigue effect by reducing the production of various metabolites during exercise-induced fatigue in rats.关键词：Exercise-induced fatigue;Qihuo Yin;treadmill;behavior sciences;rat
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发布时间：2023-04-10 -
Discussion on the thought of ZHAO Bing-nan’s blood-drawing therapy in treating sores of yin syndrome
摘要：引血疗法是赵炳南先生独树一帜的外治疗法,赵老将引血疗法引入外科阴证性疾患的治疗,开创该类疾病引血治疗之先河。阴证疮疡的病机在于虚、瘀并存,由瘀致虚,或由虚致瘀,虚瘀致寒,寒重瘀重虚重。赵老早年将引血疗法用于外科时毒壅盛的实证,但后期独辟蹊径,大胆使用引血疗法治疗阴证疮疡,充分体现其"呼脓去腐""煨脓长肉""回阳化腐生肌""祛瘀生新"学术思想,后世在引血治疗阴证思想指导下将此疗法用于各类外科疾病的临床实践。引血疗法治疗阴证疮疡的中医机制在于变瘀为通、变静为动、祛瘀通络、温阳生新,从而瘀去新生、阳气得复,达到治愈疾病的目的。而西医机制在于改善微循环及局部缺血缺氧状态,促进组织细胞恢复,增强细胞免疫功能。关键词：赵炳南;阴证疮疡;刺络放血;引血疗法- 2
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发布时间：2023-04-10 - 摘要：缺血性脑血管病属中医学"中风"范畴,现多认为由体内脏腑阴阳失调、气血逆乱导致。高利教授认为痰为缺血性脑血管病的首要病因,脾胃虚损、痰浊内生为基本病机。临证时以治痰为基本治则,根据兼证灵活运用清热、燥湿、通腑、健脾、调气、化瘀等治法,健运脾胃、治痰之本思想贯穿治疗始终,形成其独特的辨证思路和用药特色,取得了较好的临床疗效。关键词：高利;缺血性脑血管病;从痰论治;老中医经验
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发布时间：2023-04-10 - 摘要：冲任二脉隶属奇经八脉,乃肝、脾、肾三脏所系,与女性经、带、胎、产息息相关。冲任如"湖""海"一般,水满则溢,月事如常,得以荫胎;虚损则涸,血枯经闭,终致不孕。马大正主任认为,冲任既虚,药少而力不逮,宜大剂血肉有情之品,填补奇经,滋养胞宫。本文介绍马大正主任运用填补冲任法治疗闭经和不孕症的经验,以飨同道。关键词：填补冲任法;崩漏;不孕症;妇科病;马大正
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发布时间：2023-04-10 - 摘要：基于周易水火"既济"与"未济"理论,从生理、病理方面探讨睡眠与心肾交感的关系,指出肾（坎）中之阳、心（离）中之阴在心肾交感的过程中发挥关键作用,枢机健运、气机通畅是心肾交感的重要条件,提出以温肾助阳、滋养心阴之法促进心肾交感,以交通心肾、健运枢机之法治疗心肾不交型失眠。关键词：水火既济;水火未济;失眠;心肾不交
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发布时间：2023-04-10 - 摘要：慢性胃炎是一种常见的消化系统疾病,其病程迁延,常反复发作,严重影响患者的生活质量。杨晋翔教授认为本病病位在胃,胃为多气多血之腑,其与脾以膜相连,互为表里,因此脾胃与气血息息相关,脾胃功能运化失常,每多反映在气血方面;临床以"通"字为法,调气和血治疗慢性胃炎效果显著。关键词：调气和血;慢性胃炎;中医;临床经验
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发布时间：2023-04-10 - 摘要：三焦通行气、液,联系沟通脏腑,是人体气化的载体,三焦气化实质上是人体新陈代谢功能的概括。目前,关于代谢综合征中医病机的认识尚未统一,基于上述对三焦及三焦气化的理解,笔者认为代谢综合征的病机为三焦气化失常。临床及实验研究均证实五苓散是治疗代谢综合征的有效方剂。基于三焦气化理论,从中医角度进一步阐释五苓散的作用机理,认为五苓散作用于三焦,利小便实际上是利三焦,恢复三焦气化,可用于治疗具有水湿痰浊壅盛表现的代谢综合征。关键词：三焦气化;代谢综合征;五苓散
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发布时间：2023-04-10 - 摘要：健忘是指大脑的思考能力、检索能力出现了暂时的障碍,以记忆力减退、遇事易忘等脑功能减退为主要表现的一种临床病症。现代医学治疗健忘症的手段十分有限,本病虽然表现为大脑功能的异常,但是其发病与脾有着密切的联系,脾为后天之本,化生气血,运化水液,与胃同为三焦枢纽主管气机升降。从调脾出发,以健脾化湿、益气补血、调和升降为基本治法可有效控制健忘病情的发展,缓解症状。关键词：健忘;中医辨证;从脾论治
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发布时间：2023-04-10 - 摘要：癫痫作为一种发作性脑部疾病,其发作具有短暂性、重复性和刻板性的特征,且发作期与间歇期交替,时发时止。对于癫痫发作的病机,历来并无统一说法。本文主要从伏邪致病、少阳枢机不利、中焦气机不畅、节律紊乱以及玄府病变五个角度论述癫痫发作的中医学病机,并探讨中西医发病机制间的联系,以期从病机的角度为癫痫的临床诊疗提供思路。关键词：癫痫;发作;病机
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发布时间：2023-04-10 - 摘要：风痱病是中国古代常见急危重症,在《千金翼方》中详细记载了风痱病治疗的次第与方法,通过对其治疗次第与用药的分析,探析急危重症当中所体现出的危急性、复杂性、多变性等中医病机特点,并得出"使用鲜药、增速增效""谨守病机、次第渐进""方有大小、杂合以治""固本培元、病后防复"等启示,以期为急危重症的救治提供借鉴的思路。关键词：风痱病;急危重症;千金翼方;病机特点
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发布时间：2023-04-10 - 摘要：《伤寒论》中"风"字共出现70次,通过将《伤寒论》多种含"风"词语归类的方式,参阅《黄帝内经》《难经》《金匮要略》及后世医家注释、现代医家观点,基于条文对"风"字含义进行辨析。阐明《伤寒论》中"风"有本意所指自然之气与六淫之一,广义所指乘虚而感的外邪的含义。恶风、恶风寒、春伤于风、更遇于风、汗出当风,归为阐明本意所指自然之气;邪风、言迟者风也,归为阐明本意所指六淫之一;风家归为本意代指易患太阳中风之人,风池、风府归为本意代指治风之穴;将风气、泄风、风湿之风释义为乘虚而入的外邪;将中风之"风"视为与伤寒/中寒之"寒"对举,亦将"风则伤卫"与"寒则伤荣"对举;以风为阳邪之特征指代阳性症状、病机与病性,浮则为风、浮为风、浮为风虚、浮则风虚、风虚相抟、风为热、风则生微热;此为风也,归为以风指代谵语证外证之阳气外张的特点。对"风"的含义进行辨析,在厘清中医对"风"的理论认知方面有一定作用。关键词：伤寒论;风;张仲景
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发布时间：2023-04-10 - 摘要：针灸大家王乐亭创立针刺五脏俞加膈俞治疗情志病,在改善抑郁症患者情绪、缓解躯体症状、降低复发率等方面具有很好的疗效。对针刺五脏俞加膈俞治疗抑郁症的作用机制进行探讨,以期为名老中医传统经验提供证据支持,为进一步推广该法和提高抑郁症临床疗效奠定基础。关键词：抑郁症;五脏俞;膈俞;针刺
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发布时间：2023-04-10 - 摘要：目的观察凉血祛湿止痒汤治疗特应性皮炎急性发作期血热湿蕴证患者的临床疗效。方法收集特应性皮炎急性发作期血热湿蕴证患者90例,随机分为观察组和对照组,各45例。2组均予硼酸洗液湿敷,观察组予凉血祛湿止痒汤颗粒口服,对照组予氯雷他定片口服,治疗4周。比较治疗前后2组红斑、丘疹、渗出、苔藓化、皮损面积及严重度指数（EASI）、视觉模拟评分（VAS）、皮肤病生活质量指数（DLQI）及血清白介素-13（IL-13）水平变化情况。结果 2组治疗后,红斑、丘疹、渗出、苔藓化、皮损面积、EASI评分、VAS评分、DLQI评分、IL-13水平均较治疗前降低,差异有统计学意义（P <0.05）,观察组优于对照组（P <0.05）。观察组总有效率高于对照组（P <0.05）。结论凉血祛湿止痒汤可以改善特应性皮炎急性发作期血热湿蕴证患者的皮损,缓解瘙痒,提高生活质量,抑制皮肤炎症反应,疗效确切。关键词：凉血祛湿止痒汤;特应性皮炎;血热湿蕴证;中医药疗法
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发布时间：2023-04-10 - 摘要：目的观察康脉Ⅰ号胶囊对糖尿病性下肢动脉硬化闭塞症的临床疗效。方法选取糖尿病性下肢动脉硬化闭塞症患者40例,随机分为试验组和对照组各20例,对2组患者进行西医常规降糖、调脂、扩张血管等药物治疗,在此基础上,予试验组患者康脉Ⅰ号胶囊口服治疗,2组均以15 d为1个疗程,观察1个疗程。结果试验组总有效率为95%,对照组为80%,差异有统计学意义（P <0.05）; 2组患者治疗后症状积分（包括疼痛、皮肤温度、间歇性跛行）、微循环血流状态均较治疗前改善（P <0.05）,且试验组优于对照组（P <0.05）; 2组治疗后全血黏度高切、低切和血浆黏度均较治疗前降低,差异有统计学意义（P <0.05）,试验组降低更明显（P <0.05）。结论康脉Ⅰ号胶囊能够改善糖尿病性下肢动脉硬化闭塞症患者的症状及体征,同时具有改善微循环血流状态、降低血液黏稠度的作用。关键词：糖尿病性下肢动脉硬化闭塞症;康脉Ⅰ号胶囊;微循环血流
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发布时间：2023-04-10 - 摘要：目的观察双龙抗纤胶囊对风湿病肺纤维化患者生活质量的影响并进行安全性分析。方法选取河北医科大学附属石家庄平安医院风湿病肺纤维化患者80例,随机分为对照组和治疗组各40例。2组均给予风湿免疫病的基础治疗,治疗组加服双龙抗纤胶囊,对照组加服安慰剂,疗程12周。治疗前后观察肺功能变化、6 min步行试验、圣乔治呼吸问卷（SGRQ）积分、中医证候积分、高分辨CT（HRCT）评分、临床疗效指标,以及血常规、尿常规、肝功能、肾功能、心电图安全性指标。结果治疗12周后,2组的肺功能指标用力肺活量（FVC）、肺总量（TLC）、肺一氧化碳弥散量（DLCO）均较治疗前升高（P <0.05）,治疗组较对照组上述指标升高明显（P <0.05）; 2组SGRQ各项积分均较治疗前下降（P <0.05）,治疗组较对照组下降更明显（P <0.05）; 2组6 min步行距离、氧饱和度下降数、中医证候积分均较治疗前改善（P <0.05）,治疗组较对照组上述各项改善更明显（P <0.05）;治疗后2组HRCT评分均较治疗前有改善,但差异均无统计学意义（P>0.05）,治疗后组间比较亦无统计学意义（P> 0.05）。2组均有4例患者出现轻度胃脘灼痛、纳差,1～3 d自行恢复正常。2组治疗前后血常规、尿常规、便常规、肝功能、肾功能、心电图均未见异常。结论双龙抗纤胶囊可以改善风湿病肺纤维化患者肺功能和症状,提高生活质量,并具有良好的安全性。关键词：双龙抗纤胶囊;风湿病;肺纤维化;生活质量
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发布时间：2023-04-10 - 摘要：目的观察复方银花解毒颗粒治疗流行性感冒（简称"流感"）风热证的临床疗效和安全性。方法采用多中心、随机、双盲、阳性药对照临床试验设计,将158例诊断为流感风热证的受试者随机分为试验组（n=78,口服复方银花解毒颗粒）和对照组（n=80,口服磷酸奥司他韦胶囊）。观察用药前后受试者临床疗效、退热起效时间、中医证候疗效及安全性。结果治疗结束后,试验组流感临床痊愈率为23.19%,高于对照组8.97%,差异有统计学意义（P <0.05）,高于对照组;试验组流感临床总有效率（98.55%）高于对照组（93.59%）,但差异无统计学意义（P> 0.05）。试验组退热起效时间（4.08 h）短于对照组（6.00 h）,但差异无统计学意义（P <0.05）。试验组中医证候疗效痊愈率（24.64%）高于对照组（10.26%）,差异有统计学意义（P <0.05）。应急药物使用比例试验组（22.22%）与对照组（23.08%）差异无统计学意义（P> 0.05）。结论复方银花解毒颗粒治疗流感风热证安全有效。关键词：复方银花解毒颗粒;流行性感冒;风热证;奥司他韦胶囊
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发布时间：2023-04-10 - 摘要：目的探讨改良桃红四物汤治疗老年2型糖尿病合并高血压的临床疗效。方法选取2019年1—12月洪茂沟社区卫生服务站全科门诊治疗的本社区老年2型糖尿病合并高血压患者126例,随机分为对照组和观察组,各63例。2组均同时服用苯磺酸氨氯地平片5 mg/次,1次/d及阿卡波糖50 mg/次,3次/d,观察组在西医治疗基础上加服加改良桃红四物汤,比较2组患者的血压、空腹血糖、餐后2 h血糖、糖化血红蛋白及临床疗效等。结果治疗后观察组的血压、血糖、糖化血红蛋白等指标下降幅度优于对照组（P <0.05）,临床治疗总有效率（95.24%）高于对照组（66.67%）,组间差异有统计学意义（P <0.05）。结论改良桃红四物汤治疗老年2型糖尿病合并高血压的效果明显。关键词：改良桃红四物汤;糖尿病;高血压;血糖;血压;社区;疗效
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发布时间：2023-04-10 - 摘要：目的针对目前临床西医师应用中成药防治产后恶露不尽缺乏辨证的现状,探讨桂枝茯苓胶囊和安坤颗粒用于缩短产后恶露时间的作用,为明确中成药疗效及临床应用提供参考。方法对2018年10月—2019年10月在首都医科大学附属北京同仁医院南区产科分娩的225例产妇进行回顾性分析,根据其用药情况分为空白组59例、桂枝茯苓组61例、安坤组73例、桂枝茯苓与安坤联用组32例。观察比较4组患者产后恶露持续时间、恶露不尽发生率以及药物不良反应的情况。结果安坤组产后恶露持续时间明显短于其余3组（P <0.05）;而联用组与空白组则无明显差异（P> 0.05）。出现恶露不尽情况比较,安坤组出现例数明显少于其余3组（P <0.05）,恶露不尽发生率安坤组与空白组、桂枝茯苓组差异有统计学意义（P <0.05）。安坤组（0/73）、桂枝茯苓组（1/61）以及联用组（1/32）不良反应发生率组间比较差异无统计学意义（P> 0.05）。结论与应用桂枝茯苓胶囊相比,产后应用安坤颗粒可缩短恶露持续时间,减少恶露不尽发生率,且安全性良好;而安坤颗粒与桂枝茯苓胶囊联用,对缩短产后恶露持续时间并无积极作用,提示2种药可能存在寒热冲突的情况,如病情复杂确需联用,应经中医师辨证后方可使用。关键词：桂枝茯苓胶囊;安坤颗粒;恶露时间;产妇;不良反应
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发布时间：2023-04-10 - 摘要：目的采用网络药理学技术筛选丹参治疗肝纤维化的作用靶点,并探讨其治疗肝纤维化的作用机制。方法利用中药系统药理学数据库和分析平台（TCMSP）筛选丹参的主要活性成分及相应靶点,并检索OMIM、Genecard数据库以筛选肝纤维化的作用靶点。基于筛选结果,建立药物成分-靶点基因-疾病关系网络,进行基因GO功能和KEGG通路富集,以分析丹参治疗肝纤维化可能的作用机制。结果筛选出丹参主要化学成分65个,与肝纤维化相关靶点93个,关键靶点涉及AKT1、IL-6、VEGFA、EGFR、FOS等。基因GO分析提示丹参的活性主要涉及泛素-蛋白质连接酶结合、酰胺结合、细胞因子受体结合等生物学过程。KEGG富集通路提示丹参治疗肝纤维化可能涉及PI3K-AKT信号通路、IL-17信号通路、HIF-1信号通路等。结论通过网络药理学初步探究丹参治疗肝纤维化的作用机制,结果揭示丹参可能通过细胞增殖、凋亡、炎症等途径对肝纤维化发挥治疗作用,从而有效抑制肝纤维化的发展。关键词：丹参;肝纤维化;网络药理学;作用机制
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发布时间：2023-04-10 - 摘要：很多患者寻求中医药治疗时存在选择性偏好,考虑患者偏好的部分随机临床试验（partially randomized patient preference trial,PRPP）设计,在一定程度上可以应对传统的随机分组带来的方法学挑战。通过对一项PRPP设计的关于针刺与拔罐疗法对纤维肌痛综合征疗效评价研究的案例分析,对该方法的方法学原理进行介绍,并与传统的随机对照试验进行对比,探讨此方案在中医非药物疗法疗效评价研究领域的优势及可行性,为中医非药物疗法的疗效评价提供新的方法。关键词：部分随机临床试验;PRPP设计;中医非药物疗法;针刺;拔罐
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发布时间：2023-04-10 - 摘要：<正>庞鹤教授是第五批全国老中医药专家学术经验继承工作指导老师、第四批北京市名老中医,北京中医药大学东方医院主任医师,博士生导师,从事周围血管科的诊疗工作四十余年,对慢性下肢静脉疾病有着丰富的诊疗经验。慢性下肢静脉疾病在中医学中多归属于"筋瘤""水肿""湿毒疮"和"臁疮"等范畴,现代医家多从虚、湿、瘀、毒、热等角度治疗[1-3]。关键词：慢性下肢静脉疾病;益气清暑法;祛湿法;庞鹤
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发布时间：2023-04-10 - 摘要：<正>弥漫性泛细支气管炎（diffuse panbronchiolitis,DPB）是一种病因未明的、以双肺呼吸性细支气管受累为主的慢性气道炎症性疾病,东亚国家多发,且多见于非吸烟者[1]。临床表现为持续性咳嗽、咳痰、活动后喘息,容易反复感染,随着病情加重可出现呼吸衰竭而危及生命[2]。《素问·痹论篇》曰:"肺痹者,烦满喘而呕。"故现代医家多认为本病当属"肺痹"范畴。关键词：弥漫性泛细支气管炎;肺痹;理肺健脾;化痰祛瘀
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发布时间：2023-04-10 - 摘要：视网膜动脉阻塞是眼科的急症之一,临床以单眼突然无痛性视力急剧下降或丧失为主要特征,及时诊治是恢复视力的关键。目前本病还没有标准的治疗方案,中医可用中药汤剂、中成药、针刺、中药静脉制剂等治疗,疗效较好。本文对中医药治疗视网膜动脉阻塞的方法进行综述。关键词：视网膜动脉阻塞;中医治疗;文献综述
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发布时间：2023-04-10 - 摘要：带状疱疹是临床常见的皮肤病,初期皮肤水疱伴有疼痛,若治疗不易出现后遗神经疼痛,长期影响人们的生活。通过查阅带状疱疹的相关文献,综述近年来关于带状疱疹急性期的治疗方法,以求提高临床疗效,减轻患者痛苦。关键词：带状疱疹;急性期;治疗方法;文献综述
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发布时间：2023-04-10
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