最新刊期
期 11 ， 2023
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- 摘要：ObjectiveTo explore the correlation between traditional Chinese medicine （TCM） syndromes and symptoms and the revised International Prognostic Score System（IPSS-R） in patients with myelodysplastic syndrome （MDS）.MethodsThe clinical data of 80 MDS patients， who were hospitalized in the Department of Oncology and Hematology， Dongzhimen Hospital， Beijing University of Chinese Medicinefrom1 Junuary 2016 to 30 September 2021， were collected. The data of IPSS-R （hemoglobin levels， neutrophil levels， platelet levels， bone marrow blast percentages， cytogenetic results） and TCM syndromes （syndrome of antipathogenic qi deficiency and syndrome of excessive pathogenic factors）with tongue manifestations were analyzed to clarify their correlation. The correlation between IPSS-R and TCM symptoms grading of 32 out of 80 MDS patients were also investigated.ResultsBy analyzing the correlation between the distribution of IPSS-R score and TCM syndromes，deficiency of antipathogenic qi mainly included deficiency of blood and qi and deficiency of qi and yin， however， compared with extremely low risk+low risk， the proportion of spleen and kidney yang deficiency in patients with moderate risk+high risk+extremely high risk has increased significantly.In terms of tongue body，with the increase of IPSS-R score，the proportion of pale red tongue decreased， and the proportion of other tongue manifestations （including pale white， pale purple and red tongue） increased. The results of hematocytopenia and TCM syndrome distribution showed that the patients with hematocytopenia of one lineage were mainly characterized by deficiency of both qi and blood and deficiency of both qi and yin （12/33 and 10/33，respectively）. Among the patients with hematocytopenia of two lineages and three lineages， the proportion of spleen and kidney yang deficiency was higher than that of one lineage hematocytopenia. In patients who had one lineage hematocytopenia，“none” excessive pathogenic factors was the main syndrome among anemia patients （9/21）， while blood stasis was the main one among thrombocytopenia patients （6/11）. The results of correlation analysis between IPSS-R and TCM symptoms showed that fatigue grading was positively related with IPSS-R and negatively related with hemoglobin levels. The ecchymosis hemorrhage grading was negatively related with the levels of platelet；the grading of ecchymosis and hemorrhage was negatively correlated with platelet level.ConclusionThe syndrome of spleen and kidney yang deficiency may be related with the increase of IPSS-R score，multilineage cytopenia and bone marrow primordial cells.Among patients of one lineage hematocytopenia，the decrease of hemoglobin may be related to deficiency syndrome， while blood stasis may be related with neutropenia.关键词：myelodysplastic syndromes;IPSS-R;TCM syndromes;TCM symptoms
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发布时间：2023-12-25 -
- 摘要：ObjectiveTo observe the effect of meridian stream timing holographic meridian scraping on patients with allergic rhinitis （AR） of spleen-qi deficiency syndrome.Methods62 patients with allergic rhinitis of spleen-qi deficiencysyndrome，who were treated in the Otolaryngology Outpatient Department and the Traditional Chinese Medicine Characteristic Nursing Outpatient Department of Oriental Hospital of Beijing University of Chinese Medicine from October 2019 to March 2022， were divided into observation group and control group by random number table method， 31 cases in each group.In the observation group， 1 case was interrupted for personal reasons， and 30 cases were finally included.The control group took loratadine orally once a day before sleep， the observation group was given meridian stream timing holographic meridian scraping once a week for 9 am~11 am （9：00 am-11：00 am）on the basis of the control group， the course of treatment of both groups is 4 weeks.The clinical efficacy， TCM syndrome score，rhinoconjunctivitis quality of life questionnaire （RQLQ） score and recurrence rate before and after treatment were observed and compared between the two groups.ResultsThe total effective rate was 93.33% in the observation group and 74.19% in the control group， and the difference between the two groups was statistically significant （P<0.05）.After treatment， the TCM syndrome score and quality of life score of the two groups were lower than before treatment （P<0.01）， and the observation group was lower than the control group （P<0.01）. Follow-up for 6 months showed that the recurrence rate was 34.8%（8/23） in the control group and 10.7%（3/28） in the observation group， and the difference between the two groups was statistically significant （P<0.05）.ConclusionThe application of meridian flow timing holographic meridian scraping to intervene allergic rhinitis with spleen qi defciency can effectively improve clinical symptoms， reduce recurrence and improve quality of life of patients.关键词：Allergic rhinitis;spleen qi deficiency syndrome;meridian stream;holographic meridian scraping
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发布时间：2023-12-25 - 摘要：ObjectiveTo establish a model of cachexia of lung cancer in C57 mice and observe the mechanism of Jianpi Yishen（strenghtening spleen and benefiting kidney）Formula on muscle consumption and the survival time of cachexia of lung cancer in order to explore the mechanism.MethodsTen C57BL/6 mice were randomly selected as normal control group； lewis lung adenocarcinoma tumor cells were injected subcutively into the armpit of C57BL/6 mice to establish tumor cachexia models， which were divided into model group，Jianpi Yishen group and megestrol acetate group of 16 mice in each group.On the second day after the inoculation of lung cancer cells， the Jianpi Yishen group was given 2.3 g/mL Jianpi Yishen recipe by gavage， 0.3 mL/ time， at 5 times the clinical equivalent dose； Megestrol acetate group was given megestrol acetate solution by gavage， 0.3 mL/ time； the model group and the normal control group were given the same volume of normal saline by gavage.Each group was given intragastric administration once a day until the 60th day.After 14 days of administration， 10 mice in each group were killed by neck-breaking， and the remaining mice were kept for survival observation. Biochemical indexes（ALB， GLB，ALB/GLB， ALT， AST，GLU， CA）， Spleen， liver and gastrocnemius mass， serum levels of TNF-α and Activin-A， as well as Activin-A，Myostatin，MuRF-1 mRNA，and expression of AMPK， beclin mRNA were detected.ResultsThere was no significant difference in body mass among groups （P>0.05）.Compared with the model group， the largest tumor diameter and tumor weight in Jianpi Yishen group and Megestrol acetate group were smaller （P<0.05）， and the largest tumor diameter and tumor weight in Jianpi Yishen group were smaller than those in Megestrol acetate group （P<0.05）. Compared with the normal control group， GLU， ALB and ALB/GLB in the model group were lower， while AST， AST/ALT and CA were higher （P<0.05）. Compared with model group， GLU， ALB， ALB/GLB in Jianpi Yishen group were higher， AST， AST/ALT and CA were lower （P<0.05）， and GLU in Megestrol acetate group was higher （P<0.05）. Compared with megestrol acetate group， the ALB/GLB of Jianpi Yishen group was higher （P<0.05）. Compared with the normal control group， the weight of spleen and liver in the model group was higher， but the weight of gastrocnemius was lower （P<0.05）. Compared with the model group， the quality of liver was lower （P<0.05） and the quality of gastrocnemius was higher （P<0.05）. Compared with megestrol acetate group， the quality of liver in Jianpi Yishen group was lower （P<0.05）. Compared with the normal control group， the levels of serum TNF-α and Activin-A in the model group were higher （P<0.05）. Compared with the model group， the serum Activin-A levels in the Jianpi Yishen group and Megestrol acetate group were lower （P<0.05）. Compared with the model group， the survival time of Jianpi Yishen group was longer （P<0.05）. Compared with the model group， the survival time of megestrol acetate group was longer， but the difference was not statistically significant （P>0.05）. Compared with megestrol acetate group， the survival time of Jianpi Yishen group was longer， but the difference was not statistically significant （P>0.05）. Compared with the normal control group， the mRNA expressions of Activin-A， Myostatin and MuRF-1 mRNA the model group were higher （P<0.05）. Compared with the model group， the expressions of Activin-A， Myostatin and MuRF-1 mRNA in the Jianpi Yishen group and Megestrol acetate group were lower （P<0.05）. Compared with megestrol acetate group， the expression of Activin-A mRNA in Jianpi Yishen group was lower （P<0.05）. Compared with the normal control group， the expression of AMPK and beclin mRNA in the model group was higher （P < 0.05）. Compared with the model group， the expressions of AMPK and beclin mRNA in Jianpi Yishen group and Megestrol acetate group were lower （P< 0.05）. Compared with megestrol acetate group， the expression of AMPK mRNA in Jianpi Yishen group was lower （P<0.05） and beclin mRNA was higher （P<0.05）ConclusionJianpi Yishen Formula can improve the inflammatory environment，inhibit skeletal muscle atrophy in mice with lung cancer exoxia and prolong the lifeby regulating the autophagolysosome pathway （ALS） and ubiquitin-proteasome pathway （UPS）.关键词：Lung tumor;mice;Lewis cells;tumor cachexia;autophagy-lysosomal pathway （ALS） and ubiquitin-proteasome （UPS）;Jianpi Yishen Formula
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发布时间：2023-12-25 - 摘要：ObjectiveTo observe the effects of Jianpi Runfu Decoction on skin lesions and cellular inflammatory factors in mice with spleen deficiency syndrome of atopic dermatitis.Methods30 male squamy-tailed rats were divided into blank control group， spleen deficiency model group， Chinese herbal medicine high-dose group， Chinese herbal medicine medium-dose group， Chinese herbal medicine low-dose group and loratadine group with 5 rats each. Except the blank control group， the other groups were made into spleen deficiency model； the Chinese medicine group was given different concentrations of Jianpi Runfu Decoction respectively， and the loratadine group was given loratadine. Theskin lesions， histopathological manifestations， skin lesionsas well as the levels of interleukin （IL）4，IL-17，IL-22 and thymic stromal lymphopoietin （TSLP） were observed in each group.ResultsThe lesions of loratadine group， high dose group and medium dose group were significantly relieved （P<0.05）， the progression of skin lesions could be slown down in low dose group.Epidermal hyperplasia and cell edema of mice in Chinese herbal medicine group and loratadine group were significantly alleviated （P<0.05）. The levels of IL-4， IL-17， IL-22 and TSLP were decreased in Chinese herbal medicine group and loratadine group （P<0.05）； serum levels of IL-4， IL-17 and TSLP decreased （P<0.05）， serum IL-22 level decreased in all groups except low-dose group （P<0.05）.ConclusionJianpi Runfu Decoction can slow down the progression of skin lesions in mice with spleen deficiency syndrome of AD， and down-regulate the levels of cellular inflammatory factors in serum and skin lesions.关键词：Jianpi Runfu Decoction;Atopic dermatitis;spleen deficiency syndrome;inflammatory factors;mice
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发布时间：2023-12-25 -
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- 摘要：ObjectiveTo explore the characteristics of congenital Yun Qi endowment of diabetic kidney disease （DKD） patients when they were born.MethodsA total of 1 698 patients with type 2 DKD admitted to Dongzhimen Hospital of Beijing University of Chinese Medicine from January 20， 2017 to January 20， 2022 were included into a case group， and 3 740 patients of type 2 diabetes with other complications into a control group. The distribution of the birth date of the patients with DKD in terms of the characteristics of Wu Yun and Six Qi was analyzed by Chi-square test， which involved the distribution of heavenly sterns （suiyun）,earthly branches,sitian,zaiquan,zhuqi,keqi，and binary Logistic regression was used to study the relationship between the incidence of DKD and the incidence of Wu Yun and Six Qi of the birth time.ResultsThe incidence of DKD was related to the heavenly sterns（suiyun）,earthly branches,sitian,zaiquan attribute of the human being born at the time. From the perspective of heavenly sterns （suiyun）， the risk of developing DKD increased by 1.551 times （P=0.004） and 1.473 times （P=0.001） in patients with type 2 diabetes born in Bing（wood excess） and Xin （water insufficiency）. From the perspective of earthly branches，the risk of developing DKD increased by 1.496 times （P=0.005） in patients with type 2 diabetes born in the year of Mao. From the perspective of Sitian， compared with Yangming Zaojin sitian， the risk of developing DKD was reduced by 0.822 times （P=0.049） in patients with type 2 diabetes born in Shaoyin Junhuo sitian， Yangming Zaojin sitian is at increased risk of DKD. From the perspective of Zaiquan， patients with type 2 diabetes born in Shaoyin Junhuo ZaiQuan had an increased risk of developing DKD by 1.217 times （P=0.049）.ConclusionCongenital Yun Qi endowment with kidney essence deficiency，liver excess and spleen deficiency，and dry heat of the yin deficiency in type 2 diabetes mellitus are easy to suffer from DKD.关键词：Wu Yun and Six Qi;diabetic kidney disease;birth time;congenital Yun Qi endowment
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发布时间：2023-12-25 - 摘要：ObjectiveTo observe the clinical effect of meridian flow timing acupoint application in the treatment of senile heart and kidney disharmony type of insomnia.MethodsA total of 60 elderly patients with heart and kidney disharmony type of insomnia who visited the Otpatient Department of Geriatrics and Respiratory Fever in Dongfang Hospital of Beijing University of Chinese Medicine from January 2019 to March 2021 were selected and divided into 2 groups with 30 patients in each group by random envelope method.The control group was given routine treatment and nursing；on the basis of the treatment method of the control group， the observation group was given meridian flow timing acupoint applicatononce d， 4h/time.Both 2 groups were treated with 10 days as one course of treatment for 2 consecutive courses.The effects of the two groups were compared， including Pittsburgh Sleep Quality Index （PSQI） score， TCM syndrome score， Quality of life score （SF-36）and Hamilton Anxiety Scale （HAMA） before and after treatment.ResultsThe total effective rate was 96.6% in the observation group and 72.4% in the control group， the difference was statistically significant （P<0.05）.After treatment， PSQI scores， TCM syndrome scores and HAMA scores of 2 groups were lower than that before treatment， while SF-36 scores were higher than that before treatment， with statistical significance （P<0.05）.In addition， PSQI scores， TCM syndrome scores and HAMA scores in the observation group were lower than those in the control group （P<0.05）， and SF-36 scores were higher than those in the control group， with statistical significance （P<0.05）.ConclusionThe treatment of senile cardio-renal disharmony with meiridian flow timing acupoint application has remarkable effect， and it can improve sleep quality and quality of life， and relieve anxiety.关键词：Meridian flow;acupoint application;cardio-renal disharmony;Insomnia;old people
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发布时间：2023-12-25 -
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