最新刊期
期 2 ， 2023
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- 摘要：ObjectiveTo study the therapeutic effect of optimized TCM hot ironing compress technique on cancer pain and the quality of life.MethodsUsing random number table method， 98 patients with malignant tumor were randomized into control group and observation group. The control group got intervention with traditional TCM hot ironing compress and the observation group with optimized TCM hot ironing compress. The pain score， quality of life， adverse events and satisfaction with care in patients with cancer pain were observed.ResultsAfter the intervention， the pain score of the observation group was lower than that of the control group， and the difference was statistically significant （P<0.01）. Compared with before treatment， the EORTC QLQ-C30 score of quality of life in the observation group was improved （P<0.05，P<0.01）， and the EORTC QLQ-C30 score and nursing satisfaction in the observation group were higher than those in the control group （P<0.05）.ConclusionThe optimized TCM hot ironing compress technique can obviously relieve cancer pain and further improve the quality of life of patients.关键词：TCM hot ironing compress technique;cancer pain;technique optimization;tumor;Chinese medicine care
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发布时间：2023-06-16 -
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- 摘要：ObjectiveTo observe the clinical effect of LT⁃4，selenium preparation combined with Qinggan Sanjie Xiaoying Prescription in the treatment of Hashimoto thyroiditis complicated with hypothyroidism.MethodsA total of 120 patients with Hashimoto thyroiditis complicated with hypothyroidism were included， who visited Department of Thyroid Disease， Sunsimiao Hospital of Beijing University of Chinese Medicine from 1 January 2021 to 31 October2021， and according to random number table method，they were divided into control group （LT⁃4）， TCM group （LT⁃4+TCM） and combined group （LT⁃4+TCM+selenium preparation）of 40 cases in each one. After 3 months of follow-up， the therapeutic effect was evaluated according to thyroid function （FT3、FT4、TSH），thyroid-related autoantibodies （TPOAb、TGAb），TCM syndrome score， thyroid disease symptom group evalluation index including HAMA， HAMD， PSQI， FSS and local symptoms of lower limbs and lymphedema score.ResultsAfter treatment，FT3 and FT4 in TCM group and the combined drug group were better than those in the control group （P<0.05），and there was no statistical difference in TSH among the three groups （P>0.05）.There was no significant difference in TPOAb and TGAb between TCM group and combined drug group （P>0.05）.The TCM syndrome score，the indexes of thyroid disease symptom groups and the lymphedema score of lower limbs in TCM group and the combined medication group were better than those in the control group （P<0.05）.ConclusionQinggan Sanjie Xiaoying Decoction combined with selenium preparation can reduce the level of thyroid autoantibodies，improve thyroid function and clinical symptoms for patients with Hashimoto thyroiditis.关键词：Hashimoto thyroiditis;hypothyroidism;Qinggan Sanjie Xiaoying Prescription;selenium
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发布时间：2023-06-16 - 摘要：ObjectiveTo explore the effect of diabetes mellitus （DM） complicated with non-alcoholic fatty liver disease （NAFLD） from deficiency， depression， phlegm and blood stagnation.MethodsA total of 95 patients with DM complicated with NAFLD admitted to our hospital from July 2019 to March 2021 were selected and divided into control group （n=47） and traditional Chinese medicine group （n=48） according to the random number table method.The two groups were given routine intervention such as diet control and exercise program.The control group was given basic treatment，while the traditional Chinese medicine group was treated with Lipi Huatan Quyu Prescription from the perspective of deficiency，depression， phlegm and blood stagnation on this basis of basic treatment.The treatment was given for four months in both groups.The clinical efficacy，liver fat content including FLI and FVF，APN，TNF⁃α，NF⁃κB of two groups were observed；reverse transcription fluorescence quantitative PCR was used to determine serum miR⁃126.The adverse reactions of two groups were recorded.ResultsAfter four months at the end of treatment，the total effective rate of TCM group was higher than that of control group （P<0.05）.The levels of fatty liver index （FLI） and fat volume fraction （FVF） in the two groups after treatment were lower than those before treatment，and those in the TCM group were lower than those in the control group （P<0.05）.The levels of adiponectin （APN） and Mir-126 in the two groups were higher than those before treatment，and those in the TCM group were higher than those in the control group.The levels of tumor necrosis factor-α （TNF-α） and NF-κB in the TCM group were significantly lower than those in the control group （P<0.05）.There were 3 cases of nausea and vomiting and 1 case of rash occurred in the control group，and 1 case of nausea and vomiting in the observation group.The incidence of adverse reactions in the observation group was lower than that in the control group，but the difference was not statistically significant.ConclusionTreatment of DM combined with non-NAFLD from deficiency，depression，phlegm and blood stagnation based on the intestinal microecology can reduce liver fat accumulation，regulate liver fat content，improve right upper abdominal pain，thirst and polydipsia and other symptoms，and regulate liver fat content，improve the level of intestinal flora and serum related factors.关键词：Lipi Huatan Quyu Prescription;diabetes;nonalcoholic fatty liver disease
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发布时间：2023-06-16 - 摘要：ObjectiveTo investigate the therapeutic effect of Qishen Yiqi （QSYQ） Dropping Pills on cancer therapeutics-related cardiac dysfunction（CTRCD）.MethodsA total of 150 malignant tumor patients with CTRCD who visited Huguosi Hospital of Chinese Medicine， Beijing University of Chinese Medicine from March 2017 to May 2021 were selected， and according to random number table method，they were divided into control group and observation group，with 75 cases in each one．The control group was given conventional western medicine treatment，and the observation group was given QSYQ Dropping Pills on the basis of the control group．Both groups were treated for one course of 4 weeks，continuously for three courses.Clinical efficacy， 6-minute walking test，BNP， heart rate variability （HRV），including SDNN， RMSSD，SDANN，PNN50， cardiac function indicators including LVEDV， LVESV， myocardial enzymology indexes including CK-MB and LDH， Serum high sensitivity C- reactive protein （CRP）， IL-6 and safety in 2 groups before and after treatment were observed and evaluated.ResultsThe total effective rate of the treatment group was 91.0%， which was significantly higher than that of the control group，that was 74.2% （P<0.05）. 6-minute walking distance，SDNN，SDANN，RMSDD， PNN50 and LVEF were significantly increased after treatment（P<0.05），The improvement of 6-minute walking distance， BNP， HRV， cardiac function， serum hs-CRP， IL-6 and myocardial enzymology in the observation group were better than those in the control group （P<0.05）. During the treatment，there was no drug-related adverse reaction in both groups（P>0.05）.ConclusionQSYQ Dropping Pills combined with conventional western medicine has better efficacy in the treatment of CTRCD than only western medicine treatment with high safety.关键词：Qishen Yiqi Dropping Pills;cancer therapeutics-related cardiac dysfunction;inflammatory factor
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发布时间：2023-06-16 - 摘要：ObjectiveTo observe the effect of low dose urokinase combined with four-step massage on autogenous arteriovenous fistula （AVF） thrombosis and explore its mechanism.MethodsA total of 86 patients with AVF thrombosis admitted to Xingtai People's Hospital from March 2020 to May 2021 were selected and divided into observation group and control group by random number table method with 43 cases in each group.The control group was given routine thrombolytic therapy with high-dose urokinase，while the observation group was given low-dose urokinase combined with four-step massage，and the treatment course of both groups was no more than 3 days.The thrombolytic effect of 2 groups was observed， the levels of coagulation function indexes ［activated partial prothrombin time （APTT），prothrombin time （PT），plasma fibrinogen （FIB），D-dimer （D-D）］，plasma C-reactive protein （CRP），soluble endothelial cell protein C receptor （sEPCR） and high mobility group protein B1 （HMGB1） were compared between the two groups before and after treatment.Treatment related side effects were recorded in 2 groups.ResultCompared with the control group，the observation group had higher internal fistula recirculation rate，shorter internal fistula lysis time，larger internal diameter at the orifice fistula，and higher initial dialysis blood flow after dissolution，with statistical significance （P<0.05）.After treatment，APTT and PT in 2 groups were longer than that before treatment，and plasma FIB and D-D，CRP，sEPCR and HMGB1 levels were lower than that before treatment， with statistical significance （P<0.05）.After treatment，the above indexes in the observation group changed more significantly than that in the control group （P<0.05）.The incidence of adverse events in observation group was lower than that in control group （P<0.05）.No serious adverse events such as thrombus loss，allergic reaction，intracranial hemorrhage and visceral hemorrhage occurred in the 2 groups，and no abnormalities were observed in other safety indicators.ConclusionThe thrombolytic effect of low-dose urokinase combined with four-step massage in the treatment of AVF thrombosis is better than that of conventional thrombolytic therapy with high-dose urokinase，which can improve the thrombolytic effect and reduce the adverse reactions of urokinase.The mechanism of action may be related to improving coagulation function and down-regulation of CRP，sEPCR and HMGB1 levels.关键词：autologous arteriovenous fistula;thrombosis;urokinase;four-step massage;coagulation function;inflammatory reaction
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发布时间：2023-06-16 - 摘要：ObjectiveTo observe the therapeutic effect and mechanism of Tongxie Yaofang combined with Sini powder on diabetes mellitus.Methods24 KK⁃Ay mice were randomly divided into model group and low， medium and high dose Chinese medicine treatment groups respectively of 6 mice in each group， and another 6 C57BL/6J mice were taken as blank control group. The low， middle and high dose groups were given the crude dosage of Chinese medicine 1.84， 3.68 and 5.52 g/（kg d） respectively， while the blank group and model group were given the same volume of distilled water once a day for 4 weeks. The changes of body mass， fasting blood glucose （FBG）， insulin （INS）， insulin resistance index （HOMA⁃IR） and corticosterone （CORT） in each group were compared. The expression levels of 11β hydroxysteroid dehydrogenase ⅰ （HSD1） and glucocorticoid receptor （GR） in hippocampus were detected by Western blotting.ResultsCompared with the blank group， the body mass of the model group was higher at the 0，1，2，3 and 4 weeks of intervention （P<0.05）. Compared with the model group， the body weight of the low， medium and high dose groups was lower in the first and second weeks of intervention （P>0.05）. At the 3rd and 4th week， the body weight of the low， middle and high dose groups was low （P<0.05）. Compared with the blank group， the FBG in the model group was higher at the 0，1，2，3 and 4 weeks of intervention （P<0.05）. Compared with the model group， the level of FBG in the low， middle and high dose groups was lower at the 0， 1， 2 and 3 weeks of intervention （P>0.05）. At the 4th week， the level of FBG in the high dose group was low （P<0.05）. Compared with the blank group， the INS level and HOMA⁃IR in the model group were higher （P<0.05）. Compared with the model group， the INS level and HOMA⁃IR in the low-dose group were lower， with no statistical significance （P>0.05）. The levels of INS and HOMA⁃IR in middle and high dose groups were lower， and the difference was statistically significant （P<0.05）. Compared with the model group， the CORT level in the low-dose group was lower， and the difference was not statistically significant （P>0.05）. CORT in middle and high dose groups was lower， and the difference was statistically significant （P<0.05）. Compared with the blank group， the expression of 11β⁃HSD1 protein in hippocampus of model group was higher， while the expression of GR protein was lower， with statistical significance （P<0.05）. Compared with the model group， the expression of 11β⁃HSD1 protein in hippocampus of the low-dose group was lower， while the expression of GR protein was higher， with no statistical significance （P>0.05）. The expression of 11β-HSD1 protein in hippocampus was low and GR protein was high in middle and high dose groups， and the difference was statistically significant （P<0.05）.ConclusionTongxie Yaofang combined with Sini Powder can decrease the level of FBG and improve insulin resistance in type 2 diabetes mice， and its mechanism may be related to the reduction of corticosterone content and the regulation of 11β-HSD1 and GR protein expression.关键词：T2DM;Tongxie Yaofang;Sini Powder;11β-Hydroxysteroid dehydrogenase;glucocorticoid receptor
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发布时间：2023-06-16 - 摘要：ObjectiveTo investigate the effects of finger vibration on ST36 and BL57 on energy metabolism in rats with exercise fatigue.MethodsA total of 45 10-week old healthy male Wistar rats， which were good at exercise， were divided into blank group， model group and finger vibration group according to random number table method， and each group was 15. For the model group and finger vibration group， a treadmill was used to establish the exercise fatigue model rat， the finger vibration group was treated by the middle finger vibrating on ST36 and BL57 with the vibration frequency of 250 times /min， each point was 5 min， and the intervention lasted for 28 days. Then， the content changes of rat blood lactate （Lac）， malondialdehyde （MDA）， urea nitrogen （BUN）， creatine kinase （CK）， adenosine triphosphate （ATP） were detected.ResultsThe level of blood urea nitrogen （BUN）， lactic acid （Lac）， and creatine kinase （CK） in the model group were significantly higher than those in the blank group， and the level of ATP in gastrocnemius was lower and the level of MDA was higher （P<0.05）. The contents of BUN， Lac and CK in the finger vibration group were significantly lower than those in the model group， the level of ATP in gastrocnemius increased significantly and the MDA content decreased significantly （P<0.05）.ConclusionFinger vibration on ST36 and BL57 can effectively accelerate the removal of metabolites and improve energy supply in exercise fatigue rats.关键词：Exercise fatigue;finger vibration method;ST36;BL57;rat
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发布时间：2023-06-16 -
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- 摘要：ObjectiveTo observe the correlation between different TCM syndrome types and laboratory indexes in patients with acute exacerbation of chronic obstructive pulmonary disease（COPD），and explore its differential diagnosis value for different TCM syndrome types.MethodsA collection of 1 693 patients（642 cases received blood routine test，580 cases received coagulation test，471 cases received biochemical test） who met the diagnostic criteria for acute exacerbation of COPD in the Department of Pulmonology，Xiyuan Hospital，China Academy of Chinese Medical Sciences from November 2018 to August 2020，were divided into 3 groups according to syndrome differentiation of TCM，namely，phlegm-heat accumulating in the lung group of 331，306 and 254 cases received blood routine，coagulation and biochemical test，phlegm-blood stasis accumulating group of 116，104 and 92 cases received blood routine，coagulation and biochemical test，and lung，spleen and kidney deficiency group of 195，195 and 125 cases received blood routine，coagulation and biochemical test.The blood routine，coagulation and biochemical indicators in patients with acute exacerbation of COPD of three groups were compared，the receiver's operating characteristic（ROC）curve were drawn，and the diagnostic performance of the observed indicators in different syndromes was evaluated.ResultsLym# and TP in the phlegm-heat accumulating in the lung group were higher than those in the lung-spleen-kidney deficiency group（P<0.05），RDW⁃CV，RDW⁃SD，APTT，D⁃D，NT⁃proBNP in the lung-spleen-kidney deficiency group were higher than those in the phlegm-heat accumulating in the lung group（P<0.05）；MCV，RDW⁃SD，D⁃D，NT⁃proBNP and UA in the phlegm-blood stasis accumulating group were higher than those in the phlegm-heat accumulating in the lung group（P<0.05），and the phlegm-heat accumulating in the lung group had higher MCHC than the phlegm-blood stasis accumulating group（P<0.05）；MCV and UA of the phlegm-blood stasis accumulating group were higher than those of the lung， spleen and kidney deficiency group（P<0.05）.When comparing Lym#+RDW⁃CV+RDW⁃SD，APTT+D⁃D，TP+NT⁃proBNP between the phlegm-heat accumulating in the lung group and the lung，spleen and kidney deficiency group，the AUC were 0.608，0.585，0.585，and the sensitivity was 81.3%，73.5%，78.0%，the specificity was 35.4%，43.5%，37.6%，respectively；MCV+MCHC+RDW⁃SD，D⁃D，UA+NT⁃proBNP were compared in the phlegm-heat accumulating in the lung group and the phlegm-blood stasis accumulating group.At the time，the AUC were 0.606，0.574，0.629，the sensitivity was 73.4%，65.4%，72.8%，and the specificity was 46.6%，53.8%，46.7%，respectively；when comparing the phlegm-blood stasis accumulating group and the lung，spleen and kidney deficiency group，the AUC were 0.571 and 0.588，the sensitivity was 30.2%，60.9%，and the specificity was 83.6% and 56.0%，respectively.ConclusionLym#，TP，RDW⁃CV，RDW⁃SD，APTT，D⁃D，NT⁃proBNP，MCV，UA and MCHC have statistical differences among different TCM syndrome types in patients with acute exacerbation of COPD，and have certain differential diagnosis value for different syndromes.关键词：Acute exacerbation of COPD;TCM syndromes;laboratory indexes
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发布时间：2023-06-16 -
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