最新刊期
期 9 ， 2023
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- 摘要：ObjectiveTo explore the impact of Shenmai Injection on myocardial injury and hemodynamics in patients with post-cardiac arrest syndrome.MethodsA retrospective study method was adopted in the study， and the patients were divided into a treatment group and a control group according to whether Shenmai Injection was used during the course of the disease. On the basis of conventional treatment， the treatment group received 100 mL of Shenmai Injection intravenously twice a day， and the surviving patients persistently received it for 7 days. The control group received conventional treatment. Survivors continued to receive it for 7 days. The changes in the mean arterial pressure （MAP）， lactic acid （Lac）， urine output， left ventricular end-diastolic diameter （LVDD）， left ventricular ejection fraction （LVEF）， brain natriuretic peptide （BNP）， high-sensitivity troponin I （hscTnI）， creatine kinase （CK）， creatine kinase isozyme-MB （CK-MB）， aspartate aminotransferase （AST）， myoglobin （MYO）， and lactate dehydrogenase （LDH） were compared between the two groups before and after treatment. The APACHE II scores， SOFA scores， and 14-day survivals of the two groups of patients were compared between the two groups.ResultsThe APACHE II scores and SOFA scores of patients in the treatment group after treatment were lower than those before treatment， and the differences were statistically significant （P<0.01）； The LVDD and LVEF of the treatment group were improved compared with those before treatment， and the differences were statistically significant （P<0.05）； The LVEFs of treatment group were higher than those of the control group， and the differences were statistically significant （P<0.05）. Compared with that before treatment， MAPs of patients in the two groups increased significantly and Lacs decreased significantly， and the differences were statistically significant （P<0.05）. The urine outputs of the treatment group increased significantly， and the differences were statistically significant （P<0.01）； after treatment， the MAP and urine output levels of the treatment group were significantly higher than those of the control group， and the differences were statistically significant （P<0.01）. The hscTnI levels of the treatment group were significantly lower than those before treatment， and the differences were statistically significant （P<0.01）. The CK， CK-MB， LDH， AST， and MYO levels of the treatment group decreased more significantly compared with those before treatment and were significantly lower than those of the control group， and the differences were statistically significant （P<0.05， P<0.01）. The CK levels of the patients in the control group decreased compared with those before treatment， and the differences were statistically significant （P<0.05）. The doses of DA and NE received by patients in the treatment group were both reduced compared with those before treatment and were lower than those of the control group， and the differences were statistically significant （P<0.05）.ConclusionShenmai Injection has a positive impact on the prognosis of patients with post-cardiac arrest syndrome， which can maintain hemodynamic stability， reduce myocardial damage， and improve patient prognosis.关键词：Post-cardiac arrest syndrome;myocardial injury;Shenmai Injection;hemodynamics
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发布时间：2023-10-23 -
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- 摘要：ObjectiveTo explore the effect and mechanism of Sanshen Tongmai Mixture on chronic heart failure （CHF）.MethodEight rats were randomly selected as the normal control group， fed normally， and given saline 1 mL/100 g once a day.The other 96 rats were randomly divided into model group， microRNA146a mimic group， micro146a inhibitor group， high-dose drug group， medium dose drug group， low dose drug group， microRNA146a mimic+ high-dose group， microRNA146a mimic+ medium dose drug group， microRNA146a mimic+ low-dose drug group， microRNA146a inhibitor+ high-dose drug group， microRNA146a inhibitor+ medium dose drug group MicroRNA146a inhibitor+low-dose drug group with 8 in each group.Each microRNA146a mimic group was injected microRNA146amimic 0.2 μL/g into rat myocardium， and each microRNA146a inhibitor group injected microRNA146a inhibitor 0.2 μL/g into rat myocardium， 24 hours later，CHF model was made， the model group， high-dose drug group， medium-dose drug group and low-dose drug group were established on the same day. After modeling， the high-dose drug group， medium-dose drug group and low-dose drug group were given Sanshen Tongmai Mixture by gavage with 3，2，and 1 ml/100 g of Sanshen Tongmai mixture were respectively given orally for 6 weeks. The general conditions of the rats in each group were compared， including echocardiographic indexes ［left ventricular end-systolic diameter （LVIDs）， left ventricular end-diastolic diameter （LVIDd）， end-systolic interventricular septum thickness （IVSs）， diastolic interventricular septum thickness （IVSd）， left ventricular ejection fraction （LVEF） and left ventricular axial shortening rate （LVFS），pathological changes of myocardial tissue， serum levels of N-terminal pro-brain natriuretic peptide （NT-proBNP）， high-sensitivity C-reactive protein （Hs-CRP） and angiotensin II in rats， and expression of NF-κB and TRAF6 mRNA in myocardial tissue.ResultCompared with the control group， the general condition of the model group and microRNA146a inhibitor rats was worse， with more severe myocarditis reactions and cardiac function damage， and more severe myocardial cell degeneration， necrosis， and fiber proliferation. Compared with the model group， the drug group，microRNA146a mimic group and the microRNA146a mimic+drug group both had a positive intervention effect on the levels of Nt proBNP， NO， Hs CRP， and Angiotensin Ⅱ （P<0.05），echocardiographic indexes were all improved （P<0.05）. Compared with the normal group and the model group， the microRNA146a inhibitor group had a negative intervention effect on the levels of Nt-proBNP， NO， Hs-CRP and Angiotensin Ⅱ （P<0.05）.However， compared with the model group， the levels of Nt-proBNP and Angiotensin Ⅱ in the microRNA146a inhibitor+high-dose group decreased， and the difference was statistically significant （P<0.05）.Meanwhile， both microRNA146a mimic and high-dose Sanshen Tongmai drug groups significantly reduced NF-κB，TRAF6 mRNA expression.ConclusionSanshen Tongmai Mixture can effectively improve cardiac function and myocardial activity in rats with chronic heart failure， and this effect may be related to the activation of microRNA146a expression， thus down-regulating the expression of NF-κB and TRAF6.关键词：chronic heart failure;Sanshen Tongmai Mixture;microRNA146a;NF-κB/TRAF6 cell pathway;rat
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发布时间：2023-10-23 -
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