最新刊期
卷 43 ， 期 3 ， 2024
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- 摘要：Objetive To investigate the effect of Zilongjin Tablets on the survival time of patients with advanced non-small cell lung cancer.MethodsA prospective，observational real-world study was used. The research database was composed of data proactively collected for the purpose of this study，medical and health data from Beijing Hospital of Traditional Chinese Medicine. The data of patients in the Phase ⅢB~Ⅳ clinical stage were extracted. Whether or not Taking Zilongjin tablets was considered as an exposure factor. The information including patients’ demography， lung cancer diagnosis， treatment， and administration of ZilongjinTtablets were extracted and Kaplan-Meier method was used for univariate analysis，and COX model method was used for multivariate survival analysis.ResultsA total of 301 cases were included， including 99 exposed queues and 202 unexposed queues. The proportion of surgical treatment in exposed group was higher than that in non-exposed group （P<0.05）. The estimated mean survival time in the exposed cohort was 1 085.990 d［95％ CI（964.694，1 207.286）］， higher than that in the non-exposed cohort 840.074 d［95％ CI（748.942，931.207）］， the difference was statistically significant （P=0.002）. Univariate analysis showed that sex， age， pathological type， TNM clinical stage， surgical treatment and exposure to Zi Long gold tablets were related to survival time （P≤0.1）.COX survival analysis showed that older age， squamous cell carcinoma and late clinical stage were independent risk factors for terminal events， while female， surgery， chemotherapy， targeted therapy and exposure to Zilongjin Tablets were independent protective factors， among which there were statistically significant differences between clinical stage，surgery and exposure to Zilongjin Tablets （P<0.05）.ConclusionBased on the current data and analysis methods，the treatment with Zilongjin Tablets has a relatively clear protective effect on the survival in patients with advanced non-small cell lung cancer.关键词：Advanced non-small cell lung cancer;real world data;Zilongjin Tablets
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发布时间：2024-04-30 - 摘要：ObjectiveTo observe the evolution pattern of traditional Chinese medicine syndrome after radiofrequency ablation in patients with atrial fibrillation.MethodsNinety patients with atrial fibrillation who were hospitalized in the Department of Cardiology， Dongfang Hospital， Beijing University of Chinese Medicine from January 2021 to January 2023 were treated with radiofrequency ablation. Relevant data were collected preoperatively， 1 week postoperatively and 1 month postoperatively， and the TCM syndrome were analyzed.ResultsDistribution of TCM syndrome： Qi deficiency， Yin deficiency， blood stasis， phlegm， blood deficiency， Qi stagnation，Yang deficiency， and fire heat in order before RF ablation， Qi deficiency， Yin deficiency， blood stasis， phlegm， blood deficiency， Qi stagnation， fire heat， and Yang deficiency in order one week after surgery， and Qi deficiency， Yin deficiency， blood stasis， Yang deficiency， blood deficiency， Qi stagnation， phlegm， and fire heat in order one month after surgery. Evolution of TCM syndrome： blood stasis and fire-heat increased significantly one week after surgery， and blood stasis， phlegm and fire-heat decreased significantly at one month after surgery compared with one week after surgery， and phlegm decreased significantly compared with the preoperative period. Combination of TCM syndrome： preoperative and one month postoperative were dominated by two TCM syndrome combinations， followed by single TCM syndrome and three TCM syndrome combinations； one week postoperative were dominated by two TCM syndrome combinations， followed by three TCM syndrome combinations and single TCM syndrome. Cluster analysis results： Yang deficiency-phlegm-qi deficiency， qi stagnation-blood stasis， and yin deficiency-fire heat-blood deficiency in the preoperative period and one month postoperatively， and blood stasis-phlegm-yang deficiency-qi deficiency， qi stagnation， and yin deficiency-fire heat-blood deficiency one week postoperatively.ConclusionAtrial fibrillation patients before and after radiofrequency ablation had a clear pattern of evolution of TCM syndrome； qi deficiency and yin deficiency were present throughout the whole period， blood stasis and fire-heat worsened at 1 week after surgery， and phlegm was improved markedly at 1 month after surgery； the pathogenesis of blood stasis was the most typical， and stasis of blood was easy to be combined with deficiency of yang qi and phlegm in the 1-week period after surgery， while stagnation of qi and blood stasis was the main pathogenesis of the disease in the preoperative period and the 1-month period after surgery.关键词：atrial fibrillation;radiofrequency ablation;traditional Chinese medicine syndrome
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发布时间：2024-04-30 - 摘要：ObjectiveTo explore the efficacy of subcutaneous embedding acupuncture therapy on chemotherapy-induced nausea and vomiting in children with soft tissue sarcoma（STS）.Methods74 children with STS who were admitted into the Oncology ward of our hospital from May 2021 to May 2022 were selected and were divided into control group and experimental group by random number table. All children underwent vincristine+ doxorubicin+ cyclophosphamide （VDC） treatment. The control group （37 cases） was treated with routine western medicine ondansetron hydrochloride injection with intravenous injection for antiemetic treatment. The experimental group （37 cases） was treated with external treatment of traditional Chinese medicine for subcutaneous embedding acupuncture therapy on the basis of western medicine antiemetic treatment in the control group. The chemotherapy-induced nausea and vomting（CINV） on day 1 and day 2 and functional living index-emesis（FLIE） of 2 groups before and after intervention were collected and compared.ResultsCompared with the control group， the severity of nausea， vomiting in the experimental group on chemotherapy d1 and d2 were significantly reduced （P<0.05）. Compared with the control group， the FLIE of the experimental group during chemotherapy was significantly higher（P<0.05）.ConclusionSubcutaneous embedding acupuncture therapy can significantly reduce the occurrence of CINV and improve FLIE in children with soft tissue sarcoma.关键词：Soft tissue sarcoma;children;subcutaneous embedding acupuncture;chemotherapy;nausea and vomiting
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发布时间：2024-04-30 -
- 摘要：ObjectiveTo investigate the effects of Bushen Huoxue Recipe on intestinal function and intestinal barrier on Parkinson's disease model mice.Methods72 C57 mice were randomly divided into normal group， model group， Madopar group， Bushen Huoxu Recipe low-dose group （BSHX-L group）， Bushen Huoxu Recipe medium-dose group （BSHX-M group） and Bushen Huoxu Recipe high-dose group （BSHX-H group）， with 12 mice in each group. Apart from the normal group， mice in other groups were intraperitoneally injected MPTP to induce PD model， BSHX-Lgroup， BSHX-M group and BSHX-H group were given grude herbs with 0.15， 0.3， 0.6 g/d， for two weeks consecutively； Madopar group was given Madopar 112.5mg/（kg·d） intraperitoneally， once a day for two weeks consecutively； the normal group and model group were given distilled water by intragastric administration， once a day for 14 consecutive days. The general condition and behavioral test （total open-pit movement distance， average open-pit movement speed and open-pit static time）， intestinal function test （fecal water content， small intestine charcoal powder propulsion rate， and 24 h defecation granule number）， the pathological morphology of colon and serum DAO and D-LA levels were detected and compared among the groups.ResultsCompared with the blank group， the mice in the model group showed listless spirit， dry and hard stool grains and decreased defecation volume， and the total active distance of open field was significantly reduced， the average active speed of open field was significantly slowed down， and the rest time of open field was significantly prolonged. The fecal water content and small intestine charcoal thrust rate in the model group were significantly decreased. The number of grains in 24 hours of defecation decreased （P<0.05）； Compared with the model group， the Metoba group showed abnormal agility and increased fighting times after treatment， while the above conditions were improved after treatment in all Bushen Huoxue Ricipe groups. The total active distance of open field increased significantly， the average active speed of open field increased， and the rest time of open field decreased in Metoba group and Bushen Huoxue Recipe groups. The rate of small intestine carbon dust advancing in Metoba group increased significantly . Fecal water content and 24-hour defecation granules were increased in Bushen Huoxue Recipe high-dose group （P<0.05）， inflammatory cell infiltration was improved in Metoba group and BSHX-L group， but intestinal crypt structure was still damaged. In BSHX-M group and BSHX-H group， the surface of intestinal crypts tended to be flat， the structure of glands and intestinal crypts recovered， and the degree of inflammatory cell infiltration decreased significantly. DAO and D-LA levels in Metoba group and Bushen Huoxue Recipe all dose groups were significantly decreased （all P<0.05）.ConclusionBushen Huoxue Recipe （tonifying kidney and promoting blood circulation） can significantly improve exercise state and intestinal function of PD model mice， and reduce the damage of colonic tissue structure and intestinal mucosal barrier.关键词：Bushen Huoxue Recipe;Parkinson's disease;intestinal function;intestinal barrier;mice
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发布时间：2024-04-30 - 摘要：ObjectiveTo explore the chemical composition changes of Wubeizi before and after vinegar processing by liquid chromatography-mass spectrometry （LC-MS）， and the mechanism of vinegar processing of Wubeizi from the perspective of antioxidation.MethodsLC-MS was used to compare the chemical composition characterization of water extract of Wubeizi before and after vinegar processing. The antioxidant capacity was determined by iron ion reducing energy test （FRAP）， DPPH free radical scavenging capacity test and ABTS free radical scavenging capacity test.ResultsThe ability of ferric ion reduction， the free radical scavenging ability of DPPH and the scavenging ability of ABTS of vinegar-processed Wubeizi were higher than those of Wubeizi and ascorbic acid with same concentration. That is， the iron ion reducing ability IC50， DPPH free radical scavenging ability IC50 and ABTS scavenging ability IC50 of the aqueous extract of Wubeizi processed with vinegar were superior to those of ascorbic acid with the same concentration of 29.17%， 61.47% and 39.40% respectively. 53 compounds， including gallic acid， ellagic acid， mono-O-gallic acid acyl glucose to dodeca-O-gallic acid acyl glucose， gallic acid with different polymerization degrees to quintuple gallic acid and their isomers， were identified by liquid chromatography-mass spectrometry combined with UNIFI analysis platform. The comparative analysis showed that the content of polygalactose above 5-O-gallic acid after vinegar processing was lower than that before vinegar processing， and the content of polygalactose was different. After vinegar processing， the contents of quintuple gallic acid and tetraploid gallic acid with high polymerization degree in gallic acid polymer decreased； double gallic acid， ellagic acid and gallic acid were higher than those before vinegar processing.ConclusionVinegar processing has a mild hydrolysis effect on tannins of Wubeizi， which partially hydrolyzes macromolecular gallic acid esters and produces free gallic acid monomers and oligomers， exposing more active phenolic hydroxyl groups so as to enhance the antioxidant effect.关键词：Wubeizi;vinegar processing;antioxidant
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发布时间：2024-04-30 -
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