Objective To observe the clinical effects of Zhike Qingfei Decoction on acute cough of pathogenic dryness invading lung syndrome caused by acute tracheal bronchitis. Methods Randomized,paralleled and controlled methods were used to divide patients into experimental group and control group. The control group was given basic treatment and took orally Keyu Syrup,the treatment group was treated with the basic treatment and Zhike Qingfei Decoction taken orally,and the course was five days. The VAS scores of the two groups and the scores of cough and the total clinical effectiveness in and before and after treatment were observed. Results There were no statistical significance in difference among the VAS scores,daytime cough scores,night cough scores comparison between the two groups（ P > 0. 05）,they were all decreased compared with those before the treatment,the differences were statistically significant（ P <0. 01,P < 0. 05）,more obviously decreased in the experiment group than in the control group（ P < 0. 01,P < 0. 05）. To compare the total clinical effectiveness of two groups,the effective rate was 91. 7% in the experimental group and 79. 2% in the control group,and the difference was statistically significant（ P < 0. 05）. Conclusion Zhike Qingfei Decoction can effectively improve cough caused by acute tracheal bronchitis with good clinical effect.