Objective To investigate the expression of Caveolin-1（ Cav-1） in the tongue tissues of rats with severe acute pancreatitis and the regulating action of Emodin on it. Methods Severe acute pancreatitis model was induced by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct. Male SD rats were randomly divided into model group of sham-operated group（ SO）,severe acute pancreatitis group（ SAP）,and Emodin-treated group（ Emodin）. After model establishment,Emodin was administrated orally in the Emodin group（ 10 mg/kg/each time,twice a day）,while an equal amount of normal saline was administrated in the SAP and SO group. 5 days after model establishment,analysis of histomorphology and expression of Cav-1 protein and mRNA were studied by Transmission Electron Microscope,Western-blot and Q-PCR using tongue tissues,which were collected from 8 sacrificed rats randomly chosen from each group. Results It was shown by Transmission Electron Microscope that pinocytosis bullules of vascular endothelial cell were more increased in the SAP group compared with the SO group,and fewer in the Emodin group. The expressions of Cav-1 and mRNA in the SAP group were increased compared with that of the SO group and the difference of expression was statistically significant（ P < 0. 05）. The expressions of Cav-1 and mRNA were significantly decreased in the Emodin group compared with the SAP group,and the difference of expression was statistically significant（ P < 0. 05）. Conclusion The expression of Cav-1 increases in SAP rats’ tongue tissues; and the intervention of Emodin can down-regulate the expression of Cav-1 and mRNA.