Objective To study the effects of Shuangxin Biqiu San（ SXBQS） on allergic rhinitis. Methods BN rats were immunized with a mixture of ovalbumin（ OVA） and alum into their peritoneal cavity and OVA into their nasal cavity to establish an allergic reaction（ AR）,and the rats were divided into 6 groups: control,model,CTRZ,SXBQS-high,SXBQS-mid,and SXBQS-low group.Based on behaioral evaluation,the relations of time-effect and dosage-effect in SXBQS treated AR rats were preliminarily discussed and the effects of SXBQS were studied by observing the pathological changes of nasal mucous of rats under microscope and the contents of serum Ig E and histamine were detected. Results Nasal allergic signs could be remarkable alleviated 1 hour after SXBQS were administrated orally,and this effect could last at least for 12 hours. In SXBQS-high and SXBQS-mid groups,the infiltration of inflammatory cells into nasal mucous was inhibited and the mucosal edema was alleviated. In CTRZ group and SXBQS（ high,mid and low） groups,the levels of serum Ig E were decreased compared with that of control group,the difference between the SXBQS high and mid groups with the model group had the statistical significance（ P < 0. 05）; the contents of histamine of SXBQS（ high,mid and low）groups and CTRZ group were lower than that of the model group,and the difference was statistically significant between SXBQS high group and CTRZ with model group（ P < 0. 05）. Conclusion SXBQS can exerts anti-inflammatory edema by suppressing serum Ig E and histamine levels to treat AR.