Objective To observe the clinical efficacy of Phlebitis Herbal Paste in treating acute superficial thrombophlebitis.Methods 72 patients diagnosed with acute superficial thrombophlebitis were randomly assigned into a observation group and a control group of 36 cases each. The observation group received treatment of Phlebitis Herbal Paste,while the control group was treated with Mailuo Shutong Granules,both for a course of 14 days. The changes of some inflammatory indicators（WBC,TNF-α,hs-CRP,IL-1β,IL-6） and the treatment of thrombosis of two groups were compared at the end of treatment. Results The total effective rates of the observation group and the control group were 97. 22% and 88. 89% respectively,and the difference was statistically significant（P <0. 05）. The levels of TNF-α,hs-CRP,IL-1β,IL-6 after the treatment were significantly reduced in both two groups, and the differences were statistically significant（P < 0. 05）. The levels of TNF-α,hs-CRP,IL-1β,IL-6 of the observation group were much more reduced than that of the control group,and the differences were statistically significant（P < 0. 05）. Conclusion Phlebitis Herbal Paste can treat acute superficial thrombophlebitis through regulating hs-CRP, IL-6, and TNF-α levels with satisfactory clinical efficacy.