Objective To observe the clinical effects of self-made prescription Tuire Lishi Decoction in treating common cold of summer heat-dampness syndrome. Methods Sixty-four patients with common cold of summer heat-dampness syndrome were divided into experimental group and control group by random,parallel and controlled method. The control group was given with Telronin sustainedrelease tablets orally. The experimental group was given with Tuire Lishi Decoction orally. The courses of both two groups were 72 hours. The antipyretic time,the changes of syndrome scores before and after the treatment,and the total clinical efficacy was observed and compared between the two groups. Results The total effective rate of the experimental group and the control group were 73. 3% and66. 7% respectively,and the difference was statistically significant（P < 0. 05）; the time of fever reduced was 17. 57 ± 8. 96 hours in the experimental group and 23. 20 ± 8. 30 hours in the control group,the difference was also statistically significant（P < 0. 05）. The syndrome scores of hot sensation of the body,heaviness of the body and poor appetite of two groups were both improved after the treatment than that before the treatment,and the difference was statistically significant（P < 0. 05,P < 0. 01）,the difference of two groups was also statistically significant（P < 0. 05）. The difference of scores of thirsty of the experimental group before and after the treatment was statistically significant（P < 0. 05）,but not in the control group（P > 0. 05）. the difference between the two groups was also not statistically significant（P > 0. 05）. Conclusion Tuire Lishi Decoction can reduce fever,effectively and improve other symptoms in common cold with summer heat-dampness syndromes with good clinical efficacy.