Objective To observe the clinical effect of retention enema with Chinese herbal medicines combined with colonic dialysis on chronic kidney disease（ CKD） at stage III and IV. Methods 90 patients were randomly divided into control group and treatment group,each with 45 cases. All the patients were treated with conventional therapy,while the treatment group was also given retention enema with Chinese herbal medicines combined with colonic dialysis. The clinical symptoms,curative effect,the changes of renal function,uric acid and serum phosphorus of two groups were observed before and after the treatment. Results After treatment,the clinical symptoms,curative effect,renal function,uric acid,and blood phosphorus were significantly improved in both two groups（ P < 0. 05,P < 0. 01）,and the effect of the treatment group was better than that of the control group（ P < 0. 05,P < 0. 01）. Conclusion Retention enema with Chinese herbal medicines combined with colonic dialysis is effective for patients with CKD at stage III and IV,and can delay the progress of CKD.