Objective To observe the clinical efficacy,quality of life and adverse reactions of Chinese herbal medicine Yiqi Jianpi Prescription combined with S-1 treatment for aged cases of advanced gastric cancer. Methods A total of 85 aged cases with advanced gastric cancer were retrospectively analyzed. These cases were divided into two groups. The control group was treated with S-1 taken orally only,and the observation group was given S-1 and Chinese herbal medicine Yiqi Jianpi Prescription orally; 28 days constituted one course. The patient’ s general condition and hematological indexes were observed and the efficacy evaluated after 4 courses of treatment with one year following-up of survival rate and overall survival time. Results After 4 courses of treatment,Karnofsky scores（ KPS） improvement rate of the control group was lower than that of the observation group,and the difference had statistical significance（ P ,<, 0. 05）. TheⅡ ,Ⅳ neutrophil decline rate of the control group was higher than that of the observation group,and the difference had statistical significance（ P ,<, 0. 05）. The difference of digestive tract adverse reactions had no statistical significance between the two groups and the difference had no statistical significance（ P ,>, 0. 05）. The recent remission rate（ CR + PR） of the control group and the observation group were 50. 0% and 58. 5% respectively,and the difference had no statistical significance（ P ,>, 0. 05）. The one year survival rate between the two groups（ 61. 4%,75. 6%） also had no statistical significance（ P ,>, 0. 05）. Kaplan-Meier survival curve demonstrated that median survival time of the control group was 12. 6 month and that of the observation group was 15. 6 months,and the difference was statically significant（ P ,<, 0. 05）. Conclusion Chinese Herbal Medicine Yiqi Jianpi Prescription combined with S-1 taken oral could improve the quality of life,reduce the adverse reactions caused by chemotherapy and prolong the overall survival time in aged patients with advanced gastric cancer.