Objective To evaluate the short term efficacy of Jianpi Wenshen Qinghua Formula（strengthening spleen,warming kidney,cleaning heat and dispelling dampness,and dispersing blood stasis） for ulcerative colitis（UC）. Methods According to the multi-centered,randomized,and controlled clinical study design,80 patients with UC were divided into trial group of 37 case and control group of 35 cases.Mesalazine was taken as the basic treatment,the two groups were respectively treated by Jianpi Wenshen Qinghua Formula for enema and sulfasalazine suppository with anus for 4 weeks,and the remission rate and clinical curative effect of two groups were compared. Results At the end of treatment,the remission rate of the trial group was 56. 8% and that of the control group was 40. 0%,and the difference has no statistically significance（P > 0. 05）. the remission rate of diarrhea symptom in trial group was 97. 2% while that was 78. 8% in the control group and the difference was statistically significant（P < 0. 05）,and the effective rate of rest symptoms including purulent bloody stool,abdominal pain and distention between the two groups had no statistically significant difference（P > 0. 05）. Conclusion Jianpi Wenshen Qinghua Formula has equivalent effect with Sulfasalopyridine suppository in the treatment of UC,but it can better improve diarrhea.