Objective To investigate the effect of Liqi Jianpi Formula-invigorating spleen qi on esophageal and gastric varices bleeding （EGVB） in patients with cirrhosis. Methods A total of 427 cases of patients with liver cirrhosis accompanied by esophageal gastric varices,who flowed the inclusion criteria,were collected from January 2010 to July 2016 in Beijing Ditan Hospital affiliated to the Capital Medical University,and they were followed up for 1 year. According to the fact whether EGVB occurred or not,they were divided into bleeding group and non-bleeding group,Logistic regression method was used to analyze the independent risk factors for the happening of EGVB,and the prevention effect of the formula on EGVB observed. Results Whether Liqi Jianpi Formula was taken or not is one of the independent risk factors of EGVB for patients with cirrhosis within one year. Of the two groups by 1∶1 propensity score matching,EGVB in Liqi Jianpi Formula group accounted for 21. 9%,in control group 48. 5%,and EGVB was reduced by 26. 6% in Liqi Jianpi Forumla group compared with that of the control group,and difference was statistically significant （P = 0. 002）; for the time from follow-up to EGVB,Liqi Jianpi Forumla group was（8. 4 ± 0. 3） months,the control group was（5. 3 ± 0. 2） months,the two groups had statistical difference （P < 0. 01）. Conclusion Liqi Jianpi Formula can reduce the incidence of EGVB within 1 year in patients with cirrhosis,extend time in liver cirrhosis patients with esophageal gastric varices with no bleeding.