Objective To examine the action mechanism of Qishen Yiqi Dropping Pills（QYDP） on microcirculation disorder in diabetic rats with laser Doppler blood perfusion imaging techniques.Methods Streptozocin（STZ） intraperitoneal injection was used to establish a model of diabetic rats,then they were randomly divided into model group,treatment group and control group.At the same time,a normal control group was set up.The treatment group was medicated with QYDP（prepared into liquid）,while the control group with calcium dobesilate liquor（1 g/kg per day） both for 10 months.The blood flow of iris vessels,auricle and limb skin was monitored by laser Doppler blood perfusion image after drug intervention.Results The blood circulation in iris vessels,auricle and limb skin in model group were reduced,and compared with the treatment group and control group,the difference was statistically significant（P<0.05,P<0.01）.Conclusion QYDP can facilitate the peripheral microcirculation and promote the amount of blood perfusion per unit area so as to improve the ischemia of peripheral circulation.