To observe the effects of Astragalus membranaceus,Curcuma and its compatibility on the number of lung metastases and tumor epithelial-mesenchymal transition in Lewis tumor-bearing mice in order to study the role of epithelial-mesenchymal transition mechanism in inhibiting tumor metastasis, and analyze the application significance of Radix Astragali and Rhizoma Zedoariae compatibility.Methods Fifty mice with C57 Lewis tumors were randomly divided into model group,Cisplatin group,Huangqi single drug group,Ezhu single drug group and compatibility group.The mice were given drug intervention accordingly for 15 consecutive days after inoculation.The lungs were dissected for observation,and the number of nodules as big as more than 2 mm over the surface of the lungs was observed under a dissecting microscope; the tumor was removed from the underarms and the EnVision method was used to detect E-cad,MMP-2,and MMP-9 in the tumor tissues.Results The number of pulmonary metastatic nodules in the cisplatin group and the compatibility group was lower than that in the model group（P<0.05）.The number of lung metastases in two monotherapy groups was less than that of the model group but there was no statistical difference;that in each Chinese medicine group was inferior to that in the cisplatin group（P<0.05）,that in the compatibility group was less than that in the Huangqi and Ezhu group,but the difference did not show statistical significance.E-cad expression was higher in the cisplatin group and the compatibility group than in the model group（P<0.05）.There was no significant difference between the two monotherapy groups and the model group;that in the Chinese medicine group was lower than that in the cisplatin group（P<0.05）,that in the compatibility group was higher than that in the Ezhu group（P<0.05）,compared with that in the Huangqi single drug group,there was not statistically significant.The expression of MMP-2 was not statistically significant in each group（P>0.05）.The expression of MMP-9 was lower in the cisplatin group,the compatibility group,and the Ezhu group than that in the model group（P<0.05）.There was no significant difference between the Huangqi group and the model group;that in each group was higher than that in the cisplatin group（P<0.05）,that in the compatibility group was lower than that in the Huangqi single drug group,while similar to that in the Ezhu single drug group and there was no statistical difference between the compatibility group and the Huangqi monotherapy group（P<0.05）.Conclusion The effect of Huangqi-Ezhu compatibility in inhibiting tumor metastasis is better than that of Huangqi and Ezhu used singly.The mechanism may be related to the increase of E-cad protein expression and the decrease of MMP-9 expression.The combination of Huangqi and Ezhu is superior to use them singly in enhancing E-cad expression,but is similar with Ezhu and better than Huangqi in decreasing the expression of MMP-9.