Objective To observe the clinical curative effect of Methods of invigorating spleen and harmonizing stomach with warming yang and dredging diaphragm in treating gastro-esophageal reflux disease（GERD）and explore the mechanism of action and advantages of targets.It has significant meaning for the prevention and treatment of GERD with effectiveness.Methods 80 patients were randomly divided into two groups in a single blind control study.The treatment group received the decoction of invigorating spleen and harmonizing stomach with warming yang and dredging diaphragm and the control group received the Omeprazole.The course of treatment was 6 weeks.The scores of symptoms were recorded before the treatment,2 weeks,4 weeks and 6 weeks after treatment.The score of SF-36 was recorded before the treatment and 6 weeks after the treatment.The treatment group checked the esophagus 24 hours pH monitoring and inspection.Results（1）Comprehensive evaluation showed that the treatment group was better than the control group in reflux,sleeping,taking the medicine and the total score of GerdQ 6 weeks after treatment（P<0.05）.（2）In aspects of syndromes of TCM:the effective rate of the treatment group was 94.7%,while the control group was 88.9%.The difference between two groups had statistical significance（P<0.05）.The treatment group was better than the control group in reflux,belching,pharyngeal tight adverse,chest pain and the total score 6 weeks after treatment（P<0.05）.（3）The esophagus 24 hours pH monitoring and inspection:the treatment group after the treatment was better than that before the treatment in the number of reflux,time of reflux,De Meester and so on（P<0.05）.（4）SF-36:the treatment group was better than the control group in the total score 6 weeks after treatment（P<0.05）.It showed that the treatment group was better than that of control group in patients’ physical and mental health.Conclusion The therapy of invigorating spleen and harmonizing stomach with warming yang and dredging diaphragm treating has good clinical curative effect on improving the level of reflux which contribute to the physical and mental health of patients with GERD.