Objective To evaluate the complete remission rates in elderly AML（M3 excluded）patients during peri-induction chemotherapy period after receiving one course of combined treatment of induction chemotherapy and Yiyiren Oil injection.Methods Elderly inpatients（≥60 years old） in Dongzhimen Hospital from January 2009 to January 2016 were the subjects,and based on whether Yiyiren Oil injection was incorporated in the patients’ treatment regimen or not during hospitalization,these cases were divided into two groups:those who received Yiyiren Oil injection were categorized into the combined treatment group,while those who did not were placed in the simple treatment group.The clinical remission rate,TCM symptoms,sign effect and drug safety between the two groups were compared.Results After one course of induction,complete remission was seen in 13 cases（40.6 %）and partly remission in 5 cases（15.6 %）in the treatment group,and complete remission was seen in 7 cases（30.4 %）and partly remission in 5 cases（21.8 %）in the control group,the differences between the two groups were not statistically significant（P>0.05）.Bone marrow blast percentages was 4.5 in the treatment group and 9.0 in the control group.The total effect rate of TCM syndrome was 77.2 % in the treatment group,and 20.0 % in the control group,and the difference between the two groups was not statistically significant（P>0.05）.The incidence of heart,liver,and kidney toxicity after one course of induction therapy was18.7 %,31.2 %,and 12.5 % in the treatment group and 34.8 %,21.7 %,and 8.7 % in the control group respectively.The differences between the two groups were not statistically significant（P>0.05）.Conclusion Combined treatment regimen with induction chemotherapy and Yiyiren Oil injection has the effects for elderly AML（M3 excluded）patients in increasing remission rate,lower bone marrow blast percentage,more prominently in refractory or relapsed AML.Yiyiren Oil Injection has the effect of reducing chemotherapy-related cardiotoxicity in elderly patients with AML without increasing liver and kidney toxicity.