Objective To obtain and analyze the molecular mechanism and pathway of Radix Puerariae in the treatment of Parkinson’s Disease（ PD） by network pharmacology. Methods The main components and effective targets of Radix Puerariae（ RP） were summarized by TCMSP,TCMID,and target genes of PD were extracted from DisGeNET. The component-target-disease network was established by using String database and cytoscape software and GO enrichment and KEGG pathway analysis used to explore the possible targets and pathways. Results Of 63 chemical constituents of RP,13 of them were active ingredients related to PD,and 36 targets such as DECR1, BCL2, ESR1 et al. There were PI3 K-Akt signaling pathway, apoptotic pathway, HIF-1 and estrogen signaling pathway, and so on. Conclusion According to network pharmacology, the components（ formononetin, puerarin,scoparone. et al） of Pueraria lobata mainly acts on PI3 K-AKT pathway,apoptosis and estrogen signal pathways to intervene in the process of PD.