Objective To observe the clinical efficacy of modified Shenqi Dihuang Decoction in treating early stage of diabetic kidney disease（DKD）.Methods 66 cases of early DKD patients with deficiency of Qi and Yin and obstruction of collaterals were retrospectively enrolled of 33 cases in each group.The control group was given the basic treatment for diabetic nephropathy.The treatment group was given Shenqi Dihuang Decoction Granules on the basis of the control group.The clinical efficacy,TCM syndrome score,fasting blood sugar（FPG）,2 h postprandial blood glucose（2 hPBG）,glycosylated hemoglobin（HbA1 c）,blood pressure,urea nitrogen（BUN）,serum creatinine（Scr）,urinary albumin creatinine ratio（UACR）,homocysteine（HCY）and superoxide dismutase（SOD）changes of the two groups were observed after 12 weeks of treatment.Results After treatment,the clinical effect,blood glucose,blood lipid,blood pressure,and SOD in the treatment group was significantly improved compared with that before treatment,TCM syndrome score,2 hPBG,HbA1 c and UACR of the treatment groups were better than those of the control group with the difference statistically significant.Conclusion The combined treatment of modified Shenqi Dihuang Decoction with basic treatment can improve the clinical symptoms of early DKD patients with deficiency of Qi and Yin and obstruction of collaterals and control the progress of kidney disease,and it can provide new ideas for the treatment of early DKD with traditional Chinese medicine.