Objective To study on the mechanism of Xinnaoning Capsule in treating coronary atherosclerotic heart disease（CHD）based on network pharmacology.Methods Searching the targets of Xinnaoning Capsule for the treatment of CHD through the Chinese Medicine Database（TCMSP）and disease database,and these targets were enriched and analyzed in the DAVID database,the mechanism of action of Xinnaoning Capsule in the treatment of coronary CHD was analyzed using Cytoscape for drawing,the binding degree between targets and small molecule by molecular docking technology was verified.Results There were 95 action targets in the treatment of CHD by Xinnaoning Capsule.In the enrichment analysis,the reaction and inflammatory response of the biological process cells were most significant.The TNF signaling pathway was most prominent in the KEGG analysis.Tumor necrosis factor-alpha had an active binding activity with kaempferol.Conclusion Based on network pharmacology,it is predicted the Xinnaoning Capsule for the treatment of coronary heart disease is characterized by multi-components,multi-targets and multi-pathways,so it can provide a theoretical basis for the experimental study of Xinnaoning Capsule.