Objective To evaluate the clinical efficacy and safety of Yiqi Gushen Tongluo Recipe in the treatment of early diabetic kidney disease（DKD）with deficiency of qi and Yin and stagnation of kidney collaterals.Methods 90 cases of patients meeting the criteria were included and randomly divided into treatment group and control group,45 cases each.All patients were treated with conventional western medicine,and the treatment group was supplemented with Yiqi Gushen Tongluo Recipe.After 12 weeks of treatment,serum creatinine（SCr）,and estimated glomerular filtration rate（eGFR）,urinary albumin excretion rate（UAER）,urinary albumin creatinine ratio（UACR）,superoxide dismutase（SOD）,malondialdehyde（MDA）,hypersensitive c-reactive protein（hs-CRP）,transforming growth factor β1（TGF-β1）,and TCM syndrome score and efficiency were evaluated,and the mechanism of their actions were preliminarily discussed.Results The effective rate was 93.33% in the treatment group and 73.33% in the control group.SCr and eGFR were decreased after treatment,but the difference was not statistically significant（P > 0.05）.The changes of UAER,UACR and TCM syndrome score in the treatment group were significantly better than those in the control group,with statistically significant differences（P<0.05）.Serum SOD level in the treatment group was significantly higher than that in the control group（P<0.05）.Serum levels of MDA,hs-crp and TGF-β1 were significantly lower than those of the control group（P<0.05）.No obvious adverse reactions occurred during the test.Conclusion Yiqi Gushen Tongluo Recipe can significantly improve the clinical symptoms of early DKD patients with deficiency of qi and Yin and stasis of kidney collaterals,reduce the level of urinary protein,and improve the renal function.Its mechanism may be related to the improvement of the oxidative stress and micro-inflammatory response of the body.