Objective To observe the clinical effect of Ximin Decoction on allergic rhinitis of deficient cold of lung and kidney type.Methods 100 confirmed cases of perennial allergic rhinitis in the Otolaryngology Department of the Beijing Hospital of Traditional Chinese Medicine from May 2017 to October 2018 were randomly divided into treatment group and control group, 50 cases in each.The treatment group was given Ximin decoction, while the control group was given flixonase nasal spray and/or loratadine tablets, all patients were treated for 4 weeks.Scores of clinical symptoms and RQLQ were evaluated before and after treatment, and INF-γ, IL-2, IL-4, IL-5, TGF-β, IL-17 levels in peripheral blood were detected.Results The total effective rate was 96% in the treatment group and 98.0% in the control group, no statistically significant difference was found（P>0.05）; the clinical control + significant improvement rate was 84.0% in the treatment group and 80.0% in the control group without the difference statistically significant（P >0.05）; the TNSS total scores of both groups after treatment showed no statistical significance（t=1.323, P>0.05）; the RQLQ total score of the treatment group before and after treatment was statistically significant（t=52.43, P<0.01）, the RQLQ total score of the control group before and after treatment was statistically significant（t=37.41, P<0.01）; the difference of total scores of RQLQ in the treatment group and the control group was statistically significant（t=3.006, P<0.01）; no statistical difference was found between the six groups in left, right and total nasal resistance in inhalation and exhalation（P > 0.05）.No statistical difference was found between the four groups in left and right nasal cavity volume and the minimum cross section area（P > 0.05）.The levels of INF-γ, IL-2 and TGF-β in the treatment group were significantly increased（P<0.01）after treatment, and the levels of IL-4, IL-5 and IL-17 were significantly decreased（P<0.01）, the levels of those factors were statistically significant in the control group before and after the treatment（P<0.01）.Conclusion Ximin Decoction could help relieve nasal and systemic symptoms of allergic rhinitis of deficient cold of lung and kidney type and improve the immune equilibrium.