Objective To investigate the pharmacological effects of Qingzi Xiaoban Granule（QXG）on acute dermal inflammation and allergic reaction.Methods The experimental mice were divided into control group,model group,QXG with low dosage group,QXG with medium dosage group,QXG with high dosage group and positive control group.Croton oil-induced ear inflammation mouse model was established to access the inhibition rate of the drug on ear swelling.Delayed type hypersensitivity（DTH）mouse model was established to evaluate the QXG effect on ear swelling and the immune organ index.Passive cutaneous anaphylaxis（PCA）rats model was established to examine the QXG effect on the diameter and absorbance values of the skin blue spot.Results The high-dose QXG group inhibited mouse ear swelling induced by croton oil at a rate of 15.8%,which was significantly different from that in model group（P<0.01）.The inhibition rate on DTH model ear swelling was 17.5%,the thymus index and spleen index were（1.35±0.22）mg/g and（4.40±0.47）mg/g,respectively,which were significantly different from those in model group（P<0.01）.The final size of the PCA model skin blue spot was（12.5±2.0）mm,statistically significant with the model group（P<0.05）.Conclusion QXG has a certain inhibitory effect on local acute inflammatory reaction and dermal hypersensitive reaction.