健脾化湿止血方对乙肝肝硬化食管胃静脉曲张破裂出血患者二级预防的随机对照研究

侯艺鑫; 张群; 于浩; 杨玉英; 江宇泳

doi:10.16025/j.1674-1307.2022.02.001

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健脾化湿止血方对乙肝肝硬化食管胃静脉曲张破裂出血患者二级预防的随机对照研究

临床研究 | 更新时间：2023-02-15

- 健脾化湿止血方对乙肝肝硬化食管胃静脉曲张破裂出血患者二级预防的随机对照研究
- Randomized controlled study of Jianpi Huashi Zhixue Prescription on secondary prevention of esophagogastric variceal bleeding in patients with hepatitis B cirrhosis
- 北京中医药 2022年41卷第2期页码：107-112
- 作者机构：
  
  1.首都医科大学附属北京地坛医院中西医结合二科，北京 100015
- 作者简介：
  
  侯艺鑫，女，37岁，博士，副主任医师。研究方向：中西医结合治疗慢性肝病的临床与基础研究。
  江宇泳，E-mail：jyuy11@126.com
- 基金信息：
  
  北京市科学技术委员会“首都临床特色应用研究”资助项目(Z181100001718052);北京市医院管理中心“青苗”计划专项(QML20201802);北京市中医药科技发展资金项目(QN-2020-25)
- DOI：10.16025/j.1674-1307.2022.02.001
  中图分类号：
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侯艺鑫，张群，于浩，等.健脾化湿止血方对乙肝肝硬化食管胃静脉曲张破裂出血患者二级预防的随机对照研究［J］.北京中医药，2022，41（2）：107-112.

HOU Yi-xin,ZHANG Qun,YU Hao,et al.Randomized controlled study of Jianpi Huashi Zhixue Prescription on secondary prevention of esophagogastric variceal bleeding in patients with hepatitis B cirrhosis[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(02):107-112.
侯艺鑫，张群，于浩，等.健脾化湿止血方对乙肝肝硬化食管胃静脉曲张破裂出血患者二级预防的随机对照研究［J］.北京中医药，2022，41（2）：107-112. DOI： 10.16025/j.1674-1307.2022.02.001.

HOU Yi-xin,ZHANG Qun,YU Hao,et al.Randomized controlled study of Jianpi Huashi Zhixue Prescription on secondary prevention of esophagogastric variceal bleeding in patients with hepatitis B cirrhosis[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(02):107-112. DOI： 10.16025/j.1674-1307.2022.02.001.

摘要

目的,2,探讨健脾化湿止血方对乙肝肝硬化合并食管胃静脉曲张破裂出血（EGVB）患者1年内发生再出血的临床疗效。,方法,2,选取2018年5月—2020年5月首都医科大学附属北京地坛医院收治的肝硬化EGVB患者110例，随机分为中西医结合组、西医对照组，各55例。西医对照组给予内科综合治疗，中西医结合组在此基础上加用健脾化湿止血方，疗程12周，随访至48周。观察2组患者48周内再出血率以及肝功能、中医证候评分的变化。,结果,2,第48周时，中西医结合组出血率45.5 %，西医对照组为63.6 %，2组差异有统计学意义（,P,<,0.05）。2组肝功能均较治疗前有改善，ALT、AST、TBIL均较治疗前下降，但差异无统计学意义（,P,>,0.05）；中西医结合组治疗后ALB水平与西医对照组相比显著升高，差异有统计学意义（,P,<,0.05）。中西医结合组自治疗8周起，中医证候评分较西医对照组显著下降，差异有统计学意义（,P,<,0.05）。,结论,2,健脾化湿止血方能促进乙肝肝硬化患者蛋白合成，改善中医症状，降低EGVB患者1年内再出血风险。

Abstract

Objective,2,To explore the clinical effect of Jianpi Huashi Zhixue Prescription for patients with hepatitis B cirrhosis accompanied with esophagogastric variceal bleeding (EGVB) within one year.,Methods,2,A total of 110 patients with EGVB cirrhosis admitted to Beijing Ditan Hospital Affiliated to the Capital Medical University from May 2018 to May 2020 were selected and randomly divided into integrated traditional Chinese and western medicine treatment group and western medicine control group of 55 in each one, the course of treatment was 12 weeks with 48 weeks of following up.The re-bleeding rate,liver function and the changes of TCM syndrome score of two groups were observed.,Results,2,After 48 weeks of follow-up,the bleeding rate was 45.5% in the group of integrated traditional Chinese and western medicine and 63.6% in the control group.There was statistical difference between the two groups (,P,<,0.05).After treatment,the liver function in 2 groups was both improved,ALT,AST and TBIL were decreased,but there was no statistical difference(,P,>,0.05).The ALB level of patients in the integrated traditional Chinese and western medicine treatment group after treatment was significantly higher than that in the control group,with statistical difference(,P,<,0.05).After 8 weeks of treatment,the TCM syndrome score in the integrated Chinese and western medicine group was significantly lower than that in the western medicine control group,the difference was statistically significant(,P,<,0.05).,Conclusion,2,Jianpi Huashi Zhixue Prescription can improve the liver function,promote protein synthesis and TCM symptoms in patients with hepatitis B cirrhosis,thereby reducing the risk of re-bleeding in those patients with EGVB within 1 year.

关键词

健脾化湿止血方乙肝肝硬化食管胃静脉曲张出血中医治法

Keywords

Jianpi Huashi Zhixue Prescriptionhepatitis Bliver cirrhosisesophageal and gastric varices bleedingtherapeutic method of TCM

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