结合胃镜下黏膜象辨证治疗腹型过敏性紫癜湿毒内蕴证46例临床观察

赵骞; 何松蔚; 刘畅; 王昕泰; 闫慧敏

doi:10.16025/j.1674-1307.2022.02.002

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结合胃镜下黏膜象辨证治疗腹型过敏性紫癜湿毒内蕴证46例临床观察

临床研究 | 更新时间：2023-02-15

- 结合胃镜下黏膜象辨证治疗腹型过敏性紫癜湿毒内蕴证46例临床观察
- Clinical observation on 46 cases of abdominal anaphylactoid purpura with ampness-toxin-retention syndrome treated with gastroscope mucosa syndrome differentiation
- 北京中医药 2022年41卷第2期页码：113-118
- 作者机构：
  
  1.国家儿童医学中心首都医科大学附属北京儿童医院中医科，北京 100045
- 作者简介：
  
  赵骞，男，40岁，硕士，副主任医师。研究方向：儿童消化系统疾病及风湿类疾病的中西医结合治疗。
  闫慧敏，E-mail：huiminyan@sina.com
- 基金信息：
  
  北京中医药科技发展资金项目(JJ2018-45);国家中医药管理局第六批全国老中医药专家学术经验继承项目(国中医药人教发〔2017〕29号);闫慧敏全国名老中医药专家传承工作室(国中医药人教发〔2016〕42号)
- DOI：10.16025/j.1674-1307.2022.02.002
  中图分类号：
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赵骞，何松蔚，刘畅，等.结合胃镜下黏膜象辨证治疗腹型过敏性紫癜湿毒内蕴证46例临床观察［J］.北京中医药，2022，41（2）：113-118.

ZHAO Qian,HE Song-wei,LIU Chang,et al.Clinical observation on 46 cases of abdominal anaphylactoid purpura with ampness-toxin-retention syndrome treated with gastroscope mucosa syndrome differentiation[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(02):113-118.
赵骞，何松蔚，刘畅，等.结合胃镜下黏膜象辨证治疗腹型过敏性紫癜湿毒内蕴证46例临床观察［J］.北京中医药，2022，41（2）：113-118. DOI： 10.16025/j.1674-1307.2022.02.002.

ZHAO Qian,HE Song-wei,LIU Chang,et al.Clinical observation on 46 cases of abdominal anaphylactoid purpura with ampness-toxin-retention syndrome treated with gastroscope mucosa syndrome differentiation[J]. Beijing Journal of Traditional Chinese Medicine,2022,41(02):113-118. DOI： 10.16025/j.1674-1307.2022.02.002.

摘要

目的,2,观察并评价结合胃镜下黏膜象辨证治疗腹型过敏性紫癜（HSP）的临床疗效。,方法,2,采用前瞻性、随机对照的研究方法，选择腹型HSP湿毒内蕴证患儿100例，按1∶1比例，随机分为试验组（结合胃镜下黏膜象辨证治疗）和对照组（中医辨证治疗），治疗过程中共脱落8例，最终纳入试验组、对照组各46例。2组均给予激素等常规西药治疗，对照组给予青紫止痛汤口服，试验组给予结合胃镜下黏膜象辨证调整的中药方口服，2组均治疗2周。于治疗前后分别对症状体征进行评分，观察2组患儿腹痛消失时间，及治疗前后白细胞（WBC）、C反应蛋白（CRP）、红细胞沉降率（ESR）及D-二聚体（D-Dimer）变化，判定临床疗效。,结果,2,治疗后，试验组愈显率高于对照组，腹痛、腹胀评分低于对照组，腹痛消失时间短于对照组，D-Dimer浓度低于对照组，差异均有统计学意义（,P,<,0.05）。,结论,2,结合胃镜下黏膜象辨证治疗腹型HSP湿毒内蕴证可进一步优化治疗效果。

Abstract

Objective,2,To observe and evaluate the clinical efficacy of traditional Chinese medicine with gastroscopy mucosa syndrome differentiation in the treatment of children with abdominal type allergic purpura (HSP).,Methods,2,Using prospective and randomized controlled clinical research methods,100 children with HSP (abdominal type) of the syndrome of interior accumulation of dampness and toxin were randomly divided into treatment group (TCM syndrome differentiation group)of 50 cases,and control group (TCM syndrome differentiation combined with gastroscope mucosa analysis group)of 50 cases. During treatment, 8 cases drop out, so finally there were 46 cases in each groups. Both groups were given hormone and other conventional western medicine,while apart from western medicine treatment, the control group was also given Qingzi Zhitong Decoction orally. In the treatment group,on the basis of the combination of traditional Chinese and western medicine treatment,micro syndrome differentiation was made according to the observation of mucosa under gastroscope,and then Chinese herbal medicines were adjusted. The course of treatment was 2 weeks. The symptom and sign before and after treatment were scored, the disappearance time of abdominal pain and the changes of WBC, CRP, ESR and D-dimer before and after treatment were observed in order to determine the clinical efficacy.,Results,2,After treatment, the treatment group was higher than that of the control group in the recovery rate,abdominal pain and abdominal distension scores were lower than that of the control group, abdominal pain relief time was shorter than that of the control group and D-dimer concentration was lower than that of the control group with the differences statistically significant (,P,<,0.05).,Conclusion,2,Traditional Chinese medicine combined with gastroscope mucosa differentiation can be further optimized for the treatment of abdominal allergic purpura with interiorly accumulated dampness and toxin.

关键词

腹型过敏性紫癜湿毒内蕴黏膜象胃镜微观辨证

Keywords

Abdominal anaphylactoid purpurainteriorly accumulated dampness and toxinmucosal imagegastroscopemicroscopic syndrome differentiation

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